“It’s Been Ugly”: A Large-Scale Qualitative Study into the Difficulties Frontline Doctors Faced across Two Waves of the COVID-19 PandemicArticle Published on 2021-12-102022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] added analysed Analysis Care category change collected complex COVID COVID-19 COVID-19 pandemic difficulty doctor emotional Endemic exacerbated finding frontline workers Health Service Healthcare workers infection control intensive care Ireland male Measures mitigate Moral injury nine pandemic participant Qualitative qualitative research repeated step trauma Wave [DOI] 10.3390/ijerph182413067 PMC 바로가기 [Article Type] Article
Growth, reproduction numbers and factors affecting the spread of SARS-CoV-2 novel variants of concern in the UK from October 2020 to July 2021: a modelling analysis2020년 10월부터 2021년 7월까지 영국에서 우려되는 SARS-CoV-2 신규 변종 확산에 영향을 미치는 성장, 번식 수 및 요인: 모델링 분석Article Published on 2021-11-242022-09-11 Journal: BMJ Open [Category] SARS, 변종, 치료기술, 치료제, [키워드] 95% CI Additive Model adjust affecting age Analysis B.1.1.7 B.1.351 B.1.351 variant B.1.617.2 calculate Complete concern concerning confirmed case confirmed cases COVID-19 COVID-19 test COVID-19 tests data set doubling driving effective Effectiveness Effects England Epidemiology Ethnicity Evidence evidence of exponential growth facilitated Factor Final gene target genomic Geography greater group groups growth growth rate highlight hospitalisation hospitalisations indicate Infection instantaneous Intervention Linked data Local lockdown maintain National NPI NPIs observé outbreak participant PCR peaking predominant Prevalence public health reduced Region Reproduction number RT-PCR RT-PCR Ct SARS-CoV-2 Sequencing setting severity spline Spread Stage step sustained Transmissibility Transmission vaccination Vaccine variant variants variants of concern VoC VOCs [DOI] 10.1136/bmjopen-2021-056636 PMC 바로가기 [Article Type] Article
Feasibility and Clinical Outcomes of a Step Up Noninvasive Respiratory Support Strategy in Patients with Severe COVID-19 PneumoniaArticle Published on 2021-11-222022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Activation Acute respiratory failure appear asynchrony baseline bpm clinical conducted Continuous Positive Airway Pressure COVID-19 COVID-19 patients CPAP D-dimer value Desaturation deteriorate Endotracheal intubation enrolled feasible hemodynamic instability hospitals In-hospital in-hospital mortality Intubated intubation Italian LOS Lymphocyte count median Mortality multicenter NIV noninvasive respiratory Noninvasive ventilation outcome PaO Patient patients treated patients with COVID-19 Pneumonia positive airway pressure reduce respiratory respiratory distress respiratory rate retrospective secondary step Strategy treated Trial [DOI] 10.3390/jcm10225444 PMC 바로가기 [Article Type] Article
Kite-Shaped Molecules Block SARS-CoV-2 Cell Entry at a Post-Attachment Step연 자형 분자는 상착 후 단계에서 SARS-COV-2 세포 진입을 차단합니다.Article Published on 2021-11-192022-09-10 Journal: Viruses [Category] MERS, SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-viral activity anti-viral screening Antiviral block cells Compound compounds coronavirus Coronavirus infection Coronavirus-2 COVID-19 demonstrated drug drugs human cell lines Infection inhibitory activity kidney moderate molecule not affect Outbreaks pharmacophore Prevent pseudovirus respiratory SARS-CoV-1 SARS-CoV-2 Screen screened small molecule Small molecules Spike protein step structural homology the cells Viral virus virus attachment virus entry virus post-attachment [DOI] 10.3390/v13112306 PMC 바로가기 [Article Type] Article
Non-pharmaceutical interventions, vaccination, and the SARS-CoV-2 delta variant in England: a mathematical modelling study영국의 비약물적 개입, 백신 접종, SARS-CoV-2 델타 변종: 수학적 모델링 연구Articles Published on 2021-11-132022-09-10 Journal: Lancet (London, England) [Category] MERS, SARS, 변종, [키워드] Alpha B.1.617.2 Bayesian calibrated the model capture Commonwealth condition country Coverage COVID-19 credible interval CrI cross-protection cumulative deaths delta variant described development Effectiveness England English Epidemic estimate Evidence finding Foreign funding hospital Hospital admission Hospital admissions Infection Intervention investigated lifting lockdown lockdown restriction lockdown restrictions Mathematical modelling Measures Medical Research Council mixing natural immunity NPI NPIs office pandemic parameter PCR testing per day population immunity reduced resulting risk SARS-CoV-2 transmission sensitivity step surveillance data the epidemic the SARS-CoV-2 the timing timeline Trajectories trajectory Transmissibility Transmission vaccination Vaccine variant variant of SARS-CoV-2 variants was done Wellcome Trust [DOI] 10.1016/S0140-6736(21)02276-5 PMC 바로가기 [Article Type] Articles
Evaluation of the quality of COVID-19 prevention and control by a novel comprehensive evaluation model in a tertiary general hospital: a prospective observational studyObservational Study Published on 2021-11-062022-10-04 Journal: BMC Public Health [Category] MERS, SARS, 임상, [키워드] addition adjust coefficient Combination Corona correlation country COVID-19 Critical Delphi method Efficacy coefficient method Grey Grey relationship analysis method linear MONITOR Multi-index comprehensive evaluation Prevention and control prospective observational study Quality of COVID-19 prevention and control Rank-sum ratio method regions relation relationship reported Result Spearman correlation test statistically step Subjective and objective combined weight the mean TOPSIS method was obtained was used Weighting [DOI] 10.1186/s12889-021-12032-9 PMC 바로가기 [Article Type] Observational Study
Virtual Double-System Single-Box for Absolute Dissociation Free Energy Calculations in GROMACSGROMACS에서 절대 해리 자유 에너지 계산을 위한 가상 이중 시스템 단일 상자Application Note Published on 2021-11-012022-09-10 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 치료제, [키워드] 3CL pro Antiviral applied automated calculation Combination computation described dissociation energy estimate Free free energy Gromacs inherent open PF-07321332 Pfizer power protease protocol SARS-CoV-2 step [DOI] 10.1021/acs.jcim.1c00909 PMC 바로가기 [Article Type] Application Note
Evaluation of extraction-free RT-PCR methods for faster and cheaper detection of SARS-CoV-2 using two commercial systems두 가지 상용 시스템을 사용하여 SARS-CoV-2를 더 빠르고 저렴하게 검출하기 위한 추출 없는 RT-PCR 방법 평가Article Published on 2021-11-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] analytical sensitivity approach avoidance Chain Reaction Ct values diagnostic diagnostic platform Dilution evaluated exhibited extraction extraction-free method False negative false negative result faster free water heat exposure help IMPROVE Including initial molecular molecular diagnostics MOST Nasopharyngeal swab nasopharyngeal swabs NPs nucleic acid nucleic acid extraction pandemic platform polymerase chain polymerase chain reaction protocol protocols reagent reagents real-time polymerase chain reaction reduce reducing Result RT-PCR SARS-CoV-2 SARS-CoV-2 detection specimen standard RNA step tested Viral Viral load water [DOI] 10.1016/j.ijid.2021.09.046 PMC 바로가기 [Article Type] Article
Computational workflow for functional characterization of COVID-19 through secondary data analysis보조 데이터 분석을 통한 CovID-19의 기능적 특성화를위한 계산 워크 플로Protocol Published on 2021-09-242022-09-10 Journal: STAR protocols [Category] SARS, 유전자 메커니즘, [키워드] Abstract Analysis association bioinformatics can not capture Complete complexes COVID-19 Data analysis disease feature functional Gene Expression Genomics Health Sciences heterogeneous identify immunology interactions Meta-analysis molecular mechanism molecular mechanisms multiple model systems network network analysis other diseases outcomes pathophysiological pathophysiology protein interaction protein interactions protocol RNAseq Single Cell single-cell RNA-seq Standard step Systems biology transcriptional transcriptomic underlying disease [DOI] 10.1016/j.xpro.2021.100873 PMC 바로가기 [Article Type] Protocol
A Sports Practitioner’s Perspective on the Return to Play During the Early Months of the COVID-19 Pandemic: Lessons Learned and Next StepsReview Article Published on 2021-09-132022-10-28 Journal: Sports Medicine (Auckland, N.z.) [Category] COVID-19, SARS, [키워드] addition Algorithm Contact tracing contract the virus COVID-19 event events General population healthy human-to-human transmission hygiene immune health immunized include lesson management Masks Month organization protocol pulmonary complication question return social distancing sport step Streamline Structure super-spreader events Symptoms Travel virus widespread [DOI] 10.1007/s40279-021-01503-z PMC 바로가기 [Article Type] Review Article