stomatitis – Page 3 – Communicable Diseases Research

Seroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA

미국 미네소타의 애완 동물 고양이와 개에서 SARS-COV-2 (COVID-19) 노출의 혈청 유병률

Research Article

Published on 2021-06-142022-09-01
Journal: Virulence [Category] SARS, 진단, 치료기술, 치료법,

Different Neutralization Sensitivity of SARS-CoV-2 Cell-to-Cell and Cell-Free Modes of Infection to Convalescent Sera

Article

Published on 2021-06-122022-10-28
Journal: Viruses [Category] COVID-19, SARS,

SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system

Article

Published on 2021-05-142022-10-06
Journal: Med (New York, N.Y.) [Category] SARS, 진단,

[키워드] ACE2 acute respiratory syndrome Alter angiotensin-converting enzyme 2 appear AT1-AA AT1R autoantibody backbone bind blood pressure Cell cells cellular colonize concomitant increase Control coronavirus decidua elevated expressing extravillous trophoblasts Factors fetal growth factor Hematoxylin and eosin hemodynamic highest immunohistochemistry Infection investigated Local marker occur outcomes pathophysiology Placenta placental PlGF positive pre-eclampsia Pregnancy pregnant women promote RAS receptor Recombinant spike protein reduced regulate renin-angiotensin system risk RNA SARS-CoV-2 SARS-COV-2 infection sFlt1. significantly Spike protein staining stomatitis tested treated tyrosine viral infection Viral RNA virus
[DOI] 10.1016/j.medj.2021.04.009 PMC 바로가기 [Article Type] Article

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

SARS-CoV-2 및 순환 변이체에 대한 mRNA 백신 유도 항체

Article

Published on 2021-04-012022-09-11
Journal: Nature [Category] MERS, SARS, 변종, 진단,

[키워드] anti-SARS-CoV-2 antibody arising binding BNT162b2 Cell circulating variant Clinical efficacy Clinical use Cohort Donor E484K elicited epitope Epitopes expressing IgM and IgG individual injection K417N memory B memory B cell memory B cells Moderna monoclonal antibodies monoclonal antibody mRNA mRNA vaccine mRNA vaccines mRNA-1273 Mutation N501Y N501Y mutation natural infection neutralization neutralize Neutralizing activity Pfizer-BioNTech plasma RBD RBD-specific memory B cells receptor response SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 variant SARS-CoV-2 variants selected Spike protein stomatitis tested the vaccine the vaccines titre Vaccine Vaccines variants vesicular stomatitis vesicular stomatitis virus Volunteer volunteers was reduced
[DOI] 10.1038/s41586-021-03324-6 PMC 바로가기 [Article Type] Article

Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells

비강 상피 세포의 SARS-CoV-2 감염 예방에 있어 스핑고지질을 표적으로 하는 약물의 효능을 평가하기 위한 생체 외 분석

Article

Published on 2021-03-192022-08-31
Journal: STAR protocols [Category] MERS, SARS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 amitriptyline antidepressant approved assays Cell isolation Cell-based assays. Complete Coronavirus-2 COVID-19 drug drugs targeting Efficacy epithelial cell epithelial cells evaluate Ex vivo Infection infection level infection levels inhibitor nasal epithelial cell offer Particle presenting protocol quantified Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sphingolipid Spike protein stomatitis the SARS-CoV-2 vesicular stomatitis vesicular stomatitis virus Volunteer were infected
[DOI] 10.1016/j.xpro.2021.100356 PMC 바로가기 [Article Type] Article

Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera

표준화된 바이러스 중화 분석을 통해 SARS-CoV-2에 대한 절대 중화 역가를 정량화하면 COVID-19 혈청의 교차 코호트 비교가 가능합니다

Research Article

Published on 2021-02-162022-09-10
Journal: mBio [Category] MERS, 유전자 메커니즘, 진단,

[키워드] 293T ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody biosafety level Biosafety Level 3 BSL2 BSL3 clone cohorts Combination conditions convalescent-phase plasma coronavirus coronavirus disease Coronavirus disease 2019 CoV2pp COVID-19 develop Efficacy effort ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Express G glycoprotein generate group highlight identify independent inhibit inhibitory concentration intergroup comparison intergroup comparisons level 3 limit limitations Live virus myriad NAbs neutralization neutralization potency Neutralizing antibodies neutralizing antibody Neutralizing titer overcome pandemic Particle Patient plasma positive correlation Postinfection produced pseudotyped Renilla luciferase gene respiratory SARS-CoV-2 Screen sera severe acute respiratory syndrome Coronavirus spike glycoprotein stomatitis Support therapy titer TMPRSS2 Vaccine Variability vesicular stomatitis vesicular stomatitis virus Viral viral entry viral neutralization assay virus neutralization assay VSVΔG
[DOI] 10.1128/mBio.02492-20 PMC 바로가기 [Article Type] Research Article

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

구조 유도 다가 나노바디는 SARS-CoV-2 감염을 차단하고 돌연변이 탈출을 억제합니다

Research Article

Published on 2021-02-122022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종, 진단, 치료기술,

[키워드] absence activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered alpaca antibodies antibody Attention battle binding binding mode binding modes Bivalent catalyzed caused Cell cellular membrane cellular membranes change Combination combinations complex conformation conformational change Consequences coronavirus COVID-19 cryo-EM Crystallography determined by domain effective epitope Epitopes escape mutant escape mutants Evolution experiment experiments expression fusion Health care health care systems High-risk patients immune system immunization immunized inactivated inactivated virion inactive independent induce Infection information inhalation inhibit inhibited Interaction interactions lead llama mechanism Microscopy monoclonal antibodies multivalent mutants nanobodies nanobody neutralization neutralize neutralized Neutralizing Neutralizing activity observation offer pandemic passive immunization Perspective postfusion Premature Prevent prevented Protein RBD RBDs receptor receptor ACE2 Receptor binding Receptor binding domain respiratory resulting reveal Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike trimer Science severe acute respiratory syndrome Coronavirus Simultaneous Society Spike protein spike trimers Spread stomatitis strength Structure structures suppress suppressed target membrane target membranes the RBD the SARS-CoV-2 the spike protein to define Trigger triggered triggering triggers trimeric spike trivalent Vaccines variable vesicular stomatitis vesicular stomatitis virus Viral viral escape viral infection viral infections viral spike protein virion virions virus X-ray crystallography
[DOI] 10.1126/science.abe6230 PMC 바로가기 [Article Type] Research Article

Hydroxychloroquine and the treatment of Sjogren syndrome, chronic ulcerative stomatitis, and oral lichen planus in the age of COVID-19

Review article

Published on 2021-01-012022-10-05
Journal: Oral surgery, oral medicine, oral pathology and or [Category] 치료법,

[키워드] age approved arrhythmia coronavirus disease COVID-19 dosage drug drug-to-drug interactions effective Efficacy food HCQ HCQ therapy infections lesions off-label Patient QT prolongation Safe Side effect stomatitis syndrome therapy treated Treatment ulcerative use of hydroxychloroquine
[DOI] 10.1016/j.oooo.2020.06.011 [Article Type] Review article

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling

중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 막(M) 단백질은 RIG-I/MDA-5 신호전달을 표적으로 하여 I형 및 III형 인터페론 생산을 억제합니다

Article

Published on 2020-12-282022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affected Antiviral antiviral immunity attenuate caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosolic ectopic expression ENhance evade facilitate IFN Immune suppression individuals Infection Infectious diseases inhibit Innate immunity interact interferon Interpretation IRF3 M protein MAVS mechanism membrane molecular mechanism multiprotein complex nuclear translocation pathogenic pathway Phosphorylation Protein provide Replication reported respiratory RIG-I SARS-CoV-2 SeV severe acute respiratory syndrome Coronavirus Signaling Spread stimulated stomatitis suppresse suppression TBK1 the SARS-CoV-2 TRAF3 type I type I and III IFNs vesicular stomatitis vesicular stomatitis virus Viral viral replication
[DOI] 10.1038/s41392-020-00438-7 PMC 바로가기 [Article Type] Article

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

콜레스테롤 25-수산화효소는 막 융합을 차단하여 SARS-CoV-2 복제를 억제합니다

530

Published on 2020-12-152022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alleviate Antiviral antiviral activities antiviral activity antiviral response approach blockade catalyzed caused CH25H chimeric cholesterol Clinical treatment coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 deaths drug Drug administration effective effective vaccine Effective vaccines etiological agent food germline help highlight identify inhibit SARS-CoV-2 inhibitors of SARS-CoV-2 Innate immunity interferon late endosome late endosomes mechanism membrane fusion molecular basis pathogenicity produced Replication respiratory restrict Safe SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 spike protein Significance Spike protein stomatitis supportive therapies supportive therapy suppresse Symptoms tested therapeutic Vaccine vesicular stomatitis vesicular stomatitis virus virus entry viruses
[DOI] 10.1073/pnas.2012197117 PMC 바로가기 [Article Type] 530