Atorvastatin for reduction of 28-day mortality in hospitalized COVID-19 patients: study protocol for a randomized, double-blinded, placebo-controlled, clinical trial입원한 COVID-19 환자의 28일 사망률 감소를 위한 아토르바스타틴: 무작위, 이중 맹검, 위약 대조, 임상 시험을 위한 연구 프로토콜Article Published on 2022-08-082022-09-11 Journal: Trials [Category] SARS, 임상, [키워드] 28-day mortality 95% confidence interval Acute kidney injury added adjusted odds ratio All participants all-cause mortality anti-inflammatory drug approval assigned atorvastatin being clinical Clinical improvement clinical trial clinician Consequences Consistency coronavirus COVID-19 COVID-19 patient Delta disease double-blinded drug events healthcare worker Hmg coa hospital hospitalized COVID-19 hospitalized patients In-hospital in-hospital mortality Informed consent institutional review board intensive care isolation hospital logistic regression model mass vaccination mechanical ventilation Mortality neurological once daily P-value pandemic pandemic era participant Patient performed Placebo placebo-controlled Primary outcome protocol Psychological Randomized randomized clinical trial Randomized controlled trial receive recruited reduce mortality reduced reduction Registered registry Research SARS-CoV-2 Sepsis severity severity of COVID-19 standard treatment statins Study protocol supported Tablet the patient university vaccination [DOI] 10.1186/s13063-022-06619-9 PMC 바로가기 [Article Type] Article
Pasos Hacia La Salud II: study protocol for a randomized controlled trial of a theory- and technology-enhanced physical activity intervention for Latina women, compared to the original interventionPasos Hacia La Salud II: 원래 개입과 비교하여 라틴계 여성을 위한 이론 및 기술 강화 신체 활동 개입의 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-08-012022-09-11 Journal: Trials [Category] 임상, [키워드] activity adaptation age approach ARMS assessments baseline baseline assessments benefit build change chronic disease Chronic diseases clinical Complete COVID-19 pandemic described dissemination Effect Efficacy eHealth enhanced equity exercise exploratory feature female greater Health health benefits Health promotion help helping Hispanic increased risk increases in intent-to-treat interactions Intervention intervention effect Intervention effects Latina linear long term maintain manuscript mHealth outcome participant physical activity physically Population proportion Randomized Randomized controlled trial recruited Regression model Research secondary outcome Self-efficacy Social support Study protocol Support technology treat website women [DOI] 10.1186/s13063-022-06575-4 PMC 바로가기 [Article Type] Article
Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer’s Disease (NorAD): study protocol for a randomised clinical trial and COVID-19 amendments알츠하이머병(NorAD)에서 연장 방출 구안파신을 사용한 노르아드레날린성 추가 요법: 무작위 임상 시험 및 COVID-19 수정안에 대한 연구 프로토콜Article Published on 2022-08-012022-09-11 Journal: Trials [Category] 임상, [키워드] activities activity Add-on therapy addition Adrenergic receptor affected Alzheimer's disease Alzheimer’s disease approved assessment Attention attention deficit baseline Brain burden cholinesterase inhibitor clinical trial Cognition cognitive Combination combination therapy COVID-19 Daily daily living determine disease disorder double-blind dysfunction evaluate Evidence executive Follow-up function Guanfacine Guanfacine. hyperactivity IMPROVE include interview inventory involved locus measure Mild mild to moderate moderate modulating Neuropsychiatric NorAD noradrenergic observation outcome participant pathological change pathological changes pathway Pathways Placebo placebo group placebo-controlled Primary outcome randomised receive receptor Regulation secondary Secondary outcomes Study protocol Symptom symptomatic synergistic synergistic effect Test the placebo group thought Treatment treatment group Trial [DOI] 10.1186/s13063-022-06190-3 PMC 바로가기 [Article Type] Article
Relevance of the post-COVID syndrome within rehabilitation (PoCoRe): study protocol of a multi-centre study with different specialisationsControlled Clinical Trial Published on 2022-07-292022-10-05 Journal: BMC Psychology [Category] COVID19(2023년), SARS, 임상, [키워드] addition Affect affected Anxiety Disorder benefit cardiological Catamnesis clinics cognitive comparison conducted control group Coping strategy Course COVID-19 disease Depression described discharge Dyspnea exercise fatigue functional Germany help impairment implication indication infected with SARS-CoV-2 limitations Measures neurological outpatient clinic Patient physical physical ability Post Exercise Malaise Post-COVID rehabilitation post-COVID-19 patient Probability Psychological psychological testing psychosomatic public health Quality of life receive Registered rehabilitation rehabilitation patient Relevance Seven Somatic Study protocol Symptoms syndrome the patient therapeutic interventions therapy Treatment Treatment effectiveness usual care work Work ability. [DOI] 10.1186/s40359-022-00892-8 PMC 바로가기 [Article Type] Controlled Clinical Trial
Early identification and severity prediction of acute respiratory infection (ESAR): a study protocol for a randomized controlled trial급성 호흡기 감염(ESAR)의 조기 식별 및 중증도 예측: 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-07-202022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 Acute respiratory infection alarm ARI both groups Clinical diagnosis clinical manifestations clinical trial Consensus Diagnosis diagnostic Efficacy Endpoint enrolled event group Hospitalization in both groups incidence include mechanical ventilation mNGS. multicenter Multiplex PCR non-inferiority Open-label outbreak oxygen participant pathway Patient primary endpoint Prognosis Randomized Randomized controlled trial Randomized controlled trials reached receive resource respiratory infection SARS-CoV-2 secondary Secondary endpoints Severe infection severity Study protocol tested Treatment Treatment outcome Treatment strategies two group two groups [DOI] 10.1186/s12879-022-07552-7 PMC 바로가기 [Article Type] Article
The GUIDE-HF trial of pulmonary artery pressure monitoring in heart failure: impact of the COVID-19 pandemicRandomized Controlled Trial Published on 2022-07-142022-10-05 Journal: European heart journal [Category] Fulltext, MERS, 임상, [키워드] all-cause mortality cause change changes changes in clinical Compliance Contact Control control group coronavirus disease COVID-19 COVID-19 pandemic decrease event rate events examined Factor Frequency group groups Haemodynamics heart heart failure in both groups management medication not different outcome outcomes pandemic Patient primary endpoint primary event rate pulmonary artery pulmonary artery pressure Pulmonary artery pressure. Randomized remained reported resulting Study protocol the primary endpoint Treatment treatment group Trial [DOI] 10.1093/eurheartj/ehac114 PMC 바로가기 [Article Type] Randomized Controlled Trial
Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study – a prospective population-based cohort studySARS-CoV-2 감염(ELISA) 연구의 Luebeck 종단 조사 프로토콜 - 전향적 인구 기반 코호트 연구Article Published on 2022-07-072022-09-11 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] ad-hoc anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies antibodies antibody approach Behavior clinical Clusters Cohort cohort-study cohorts coronavirus COVID-19 Critical cross-sectional defined Diseases Effect ELISA Factors follow-up study immunity after vaccination incidence include increased risk Infection Infectious diseases Intervention life Local measure methodological MONITOR National new SARS-CoV-2 other infectious diseases pandemic Participants PCR testing population level population-based cohort Prevalence Protective protocol Quality of life questionnaire Region risk Risk behaviors Risk factors SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 pandemic SARS-CoV-2 transmission selected Seroprevalence Spread Study protocol subset Surveillance Symptoms syndrome the SARS-CoV-2 Transmission vaccination rates variants [DOI] 10.1186/s12889-022-13666-z PMC 바로가기 [Article Type] Article
Mobile app and digital system for patients after myocardial infarction (afterAMI): study protocol for a randomized controlled trial심근경색 후 환자를 위한 모바일 앱 및 디지털 시스템(afterAMI): 무작위 대조 시험을 위한 연구 프로토콜Article Published on 2022-06-212022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] Acute myocardial infarction Admission analyzed cardiac Cardiac rehabilitation Cardiology cardiovascular risk factor cardiovascular risk factors Care chair clinical setting comprehensive evaluation Contact Department described discharge effective endpoints Evidence example Healthcare professional hospital IMPROVE Inclusion initial International knowledge life medical history medication Mobile Mobile App Mobile application Myocardial Myocardial infarction offer Open-label Participants Patient patients Perspective Previous studies previous study Prognosis protocol Quality of life Randomized Randomized controlled trial randomized trials recruited rehabilitation required single-center study Study protocol subject telehealth Telemedicine the patient undergo university vital sign Warsaw [DOI] 10.1186/s13063-022-06463-x PMC 바로가기 [Article Type] Article
Prevalence, Features and Degree of Association of Oral Lesions in COVID-19: A Systematic Review of Systematic ReviewsCOVID-19에서 구강 병변의 유병률, 특징 및 연관성 정도: 체계적인 검토의 체계적인 검토Article Published on 2022-06-182022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] association clinical presentation comprehension conducted coronavirus disease Coronavirus disease 2019 COVID-19 degree described determine diagnosed ENhance evaluate Evidence Features forms Frequency GRADE Health heterogeneous lesion lesions management Manifestations Meta-analysis Microbiome natural history oral oral lesions oral manifestations Pathogenesis Periodontitis Prevalence professional reported review SARS-CoV-2 SARS-COV-2 infection secondary Study protocol subject subjects systematic review systematic reviews Viral variants worsening [DOI] 10.3390/ijerph19127486 PMC 바로가기 [Article Type] Article
Evaluation of the safety and immunogenicity of different COVID-19 vaccine combinations in healthy individuals: study protocol for a randomized, subject-blinded, controlled phase 3 trial [PRIBIVAC]건강한 개인에서 다양한 COVID-19 백신 조합의 안전성 및 면역원성 평가: 무작위, 피험자 맹검, 대조 3상 시험을 위한 연구 프로토콜 [PRIBIVAC]Article Published on 2022-06-162022-09-11 Journal: Trials [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] adverse event adverse events anti-SARS-CoV-2 antibodies antibody approval best blood sample Blood samples BNT162b2 boost booster booster dose booster vaccinations cellular Cellular immune response collected Combination Comprehensive control arm Controlled clinical trial CoronaVac country COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines demonstration different time point different time points dose Effectiveness Eligible participants Endpoint enrolment evade excluded group healthy Heterologous homologous host immunity humoral immune immune profiling immune response Immunity Immunocompromised immunogenicity Immunoglobulin immunoglobulins Inactivated vaccine Infection Intervention intervention arm Laboratory test Laboratory tests Local maintain mRNA mRNA vaccine mRNA-1273 omicron over parameters participant performed persistence phase Phase 3 phase 3 trial physical population immunity pregnant primary endpoint Probability quantity raising randomization Randomized Randomized controlled trial regimen Regulatory SARS-CoV-2 SARS-COV-2 infection Serious Adverse Event Serious Adverse Events Singapore Study protocol vaccination Vaccine vaccine availability vaccine booster vaccine candidate variants variants of concern volunteers wildtype [DOI] 10.1186/s13063-022-06345-2 PMC 바로가기 [Article Type] Article