A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infectionFc 강화 NTD 결합 비중화 항체는 바이러스 확산을 지연시키고 nAb와 상승 작용하여 치명적인 SARS-CoV-2 감염으로부터 마우스를 보호합니다Article Published on 2022-02-152022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ADCC Alter anti-SARS-CoV-2 antibodies antibody approach bind Combination complex contribute convalescent coronavirus COVID-19 death Efficacy epitope Evidence Fc-effector functions Fc-mediated effector function Fc-mediated effector functions function in vivo indicate K18-hACE2 K18-hACE2 mice mice Microscopy N-terminal domain NAb Neutralizing Neutralizing antibodies Non-neutralizing antibodies non-neutralizing antibody NTD overlap Prophylactic PROTECT Replication reveal SARS-CoV-2 SARS-COV-2 infection significantly spike synergy the SARS-CoV-2 virus spread [DOI] 10.1016/j.celrep.2022.110368 PMC 바로가기 [Article Type] Article
Accounting for interactions between Sustainable Development Goals is essential for water pollution control in ChinaArticle Published on 2022-02-082022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] accounting benefit China effective Environmental impact example Interaction interactions management meeting positive Region Result Socioeconomic scenarios sustainability sustainable development goal synergy water pollution control Water resources [DOI] 10.1038/s41467-022-28351-3 PMC 바로가기 [Article Type] Article
COVID-19 Assessment and Testing in Rural Communities During the Pandemic: Cross-sectional AnalysisOriginal Paper Published on 2022-02-082022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] access assessment average Care Community community paramed conducted COVID-19 COVID-19 pandemic COVID-19 test COVID-19 testing cross-sectional analysis Digital health equipment exacerbated Health healthcare improvement objective online health pandemic Patient per day physician primary care PROTECT provided resident Result synergy Testing Triage unique Virtual care virtual health [DOI] 10.2196/30063 PMC 바로가기 [Article Type] Original Paper
Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samplesResearch article Published on 2022-02-022022-10-05 Journal: Cell chemical biology [Category] COVID19(2023년), SARS, 변종, [키워드] Anticoagulant Anticoagulants anticoagulation aptamer bind clinically cofactor collected coronavirus disease COVID-19 COVID-19 patient disrupt factor V/Va feasibility Generation Hemostasis inhibitor Interaction interactions lack low molecular weight mechanism membranes nanomolar affinity Patient plasma protamine Protein protein inhibitor protein-membrane interaction regulate reveal reversed RNA synergy target therapeutic thrombosis Whole blood [DOI] 10.1016/j.chembiol.2022.01.009 [Article Type] Research article
Low incidence of COVID-19 case severity and mortality in Africa; Could malaria co-infection provide the missing link?아프리카에서는 코로나19 사례의 심각도와 사망률이 낮습니다. 말라리아 동시 감염이 누락된 연결고리를 제공할 수 있습니까?Research Published on 2022-01-222022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, 말라리아, [키워드] antimalaria drug article Atypical caused Co-infection contrary contribute coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient Cross immunity database death Endemic Evidence fatality Hypothesis immunodominant immunodominant epitope in vitro study in vivo incidence incidence of COVID-19 incidence rate increase in indicated individual Infection information Intervention malaria malaria control Malaria-COVID 19 co-infection memory B cell Mortality mortality rate outcome Plasmodium falciparum poor prognosis prevented PROTECT provided receptor recorded Region regions reported required Result SARS-CoV-2 searched selected severity Support synergism synergy systematic review [DOI] 10.1186/s12879-022-07064-4 PMC 바로가기 [Article Type] Research
Kaposi’s Sarcoma-Associated Herpesvirus, but Not Epstein-Barr Virus, Co-infection Associates With Coronavirus Disease 2019 Severity and Outcome in South African PatientsMicrobiology Published on 2022-01-062022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] addition adjusted African age Associate Cape Cohort coronavirus 2 COVID-19 COVID-19 disease severity COVID-19 patient COVID-19 patients COVID-19 severity death detectable died disease DNA EBV Enrollment Epstein-Barr virus herpesvirus HIV HIV positive Human Infection KSHV lytic reactivation median age men Non-communicable disease outcome Oxygen therapy pandemic Patient PCR-confirmed Peripheral blood prevalent respiratory SARS-CoV-2 SARS-COV-2 infection serology seropositive Sex South South Africa supportive care synergy the WHO These data town Tuberculosis viral infection Viral load virus while women [DOI] 10.3389/fmicb.2021.795555 PMC 바로가기 [Article Type] Microbiology
COVID-19 and chronic diabetes: the perfect storm for reactivation tuberculosis?: a case seriesCase Report Published on 2021-12-162022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] Affect case sery coronavirus disease COVID-19 death diabetes Diabetes Mellitus Diagnostic delays Factor female Hispanic implementation latent tuberculosis infection lockdown males medium outcomes pandemic patients positive predicted risk SARS-CoV-2 synergy Treatment Tuberculosis type 2 diabetes [DOI] 10.1186/s13256-021-03193-7 PMC 바로가기 [Article Type] Case Report
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escapeSARS-CoV-2를 표적으로 하고 탈출에 저항하는 나노바디의 높은 시너지 조합Research Article Published on 2021-12-152022-09-10 Journal: eLife [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibody binding site Combination conserved effective epitope functional Human identify Infection inhibit SARS-CoV-2 mechanism mechanisms N-terminal domain nanobodies nanobody neutralization Prophylactic Receptor binding domain S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants single-domain antibodies spike glycoprotein subunit synergistic synergy therapeutic therapeutic antibodies Vaccine variants of concern Viral viral escape viral neutralization [DOI] 10.7554/eLife.73027 PMC 바로가기 [Article Type] Research Article
Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral TherapiesArticle Published on 2021-12-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Analysis antimetabolite Antiviral antiviral therapy blunting broad-spectrum cellular clearance clinical trial Combination competing coronavirus Defense Ebola virus effective emerging viruses Enhancing Favipiravir forms Frequency HCoV-OC43 Illness severity infections influenza A inhibitor Mutation NTP nucleobase nucleosides nucleotide orthomyxovirus Patient potency Potential purine reduced reducing reduction Replication riboside RNA virus SARS-CoV-2 small molecule Spread synergistic synergy Treatment Vaccine virus Zika [DOI] 10.3390/v13122508 PMC 바로가기 [Article Type] Article
Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin출현 SARS-COV-2 변이체 : 비교 복제 역학 및 Thapsigargin에 대한 높은 감도Research Article Published on 2021-12-122022-09-10 Journal: Virulence [Category] SARS, 변종, 치료제, [키워드] Alpha Antiviral Beta blocked Co-infection Combination controls COVID-19 pandemic Delta dominant dose effective Effectiveness emergent variants examined exhibited greater highest hpi include Infection infections inhibiting initial Post-infection priming priming dose progeny Replication Replication rate replication synergy RNA SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viruses sensitivity single variant Spectrum spread to susceptible Syncytia synergy thapsigargin variant variants Viral Viral RNA virulent virus viruses were assessed [DOI] 10.1080/21505594.2021.2006960 PMC 바로가기 [Article Type] Research Article