Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature reviewArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] applied approach bioinformatics Bioinformatics analysis Biomarker Cancer Colorectal cancer complications of COVID-19 core gene Coronavirus disease 2019 COVID-19 COVID-19 complication DEGs Diseases drug drug candidates Effect effective feature Health highest identification identify idiopathic IPF literature review lung lung cancer Lung fibrosis Metastasis molecular morbidity and mortality Mortality pathway Patient patients positive pulmonary fibrosis reducing risk risk factor significantly Spread Systems biology the epidemic the SARS-CoV-2 virus Transcriptome treating COVID-19 Treatment [DOI] 10.1038/s41598-022-20040-x PMC 바로가기
Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthmaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] 바이오마커, 유전자 메커니즘, [키워드] addition allergic Allergic asthma Analysis approach association Asthma asthmatic bioinformatics Biomarker can be used candidate drug candidate drugs Comorbidity conducted coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression COVID-19 symptom Critical dataset datasets DEGs determine differentially expressed gene disease disease biomarker drug Effect elevated Evidence expression level Gene ontology Genes health systems hub gene identify IL-13 IL-5 Increasing Interaction interactions lung mechanism molecular molecular mechanism MUC5AC murine murine model pandemic pathway Pathway analysis Patient patients with COVID-19 phenotype potential molecular risk factor severity shared pathways statistical Systems biology systems-biology. Transcription [DOI] 10.3389/fimmu.2022.988479 PMC 바로가기
Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue SyndromeArticle Published on 2022-09-162022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome analyses Analysis approach bioinformatics bioinformatics analyses biological function caused CD8A Clinical practice collected Compound condition coronavirus COVID COVID-19 infection COVID-19 pandemic CXCL8 database dataset demonstrated develop discharge enrichment analysis Evidence fatigue Genes greater healthcare help hub protein identify IL-1B IL-6 Infection information Interaction Intersection Laboratory Long Long COVID ME/CFS mechanism multicenter Myalgic encephalomyelitis/chronic fatigue syndrome network analysis nine Ontology pathway enrichment performed PPI PPI network predicted protein-protein interaction Protein–protein interaction protein–protein interaction network required SARS-CoV-2 signaling pathway Symptom syndrome Systems biology therapeutic drug TP53 Transcription transcription factor [DOI] 10.3389/fimmu.2022.952987 PMC 바로가기
Singularity and Commonality in Response to SARS-CoV-2 in Lung and Colon Cell ModelsArticle Published on 2022-09-092022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] addressed Analysis Antiviral APOBEC APOBEC3G APOBECs approach both virus Caco-2 Caco-2 cell Caco-2 cells Calu-3 Calu-3 cell Calu-3 cell line Cell cell line cellular cellular response Colon commonality Course COVID-19 dataset determine differentially expressed gene disease Diseases epithelial cell events Evidence expressed genes expression pattern Factors feature gastrointestinal tract gene expression level gene signatures host response intrinsic liver lung lung; manifestation Model molecular outcome Pathomechanism Pathways performed Perturbation provide question Research Respiratory system response SARS-CoV SARS-CoV-2 similarity Systems biology the interferon tissue expression transcriptomic translational unique [DOI] 10.3390/ijms231810451 PMC 바로가기
A How to Guide: Clinical Population Test Development and Authorization of MALDI-ToF Mass Spectrometry-Based Screening Tests for Viral InfectionsArticle Published on 2022-09-032022-11-15 Journal: Viruses [Category] 치료기술, [키워드] applied Applying Asymptomatic asymptomatic screening authorization Bacteria Bacterial CLIA CLIA-LDT clinical clinical process clinical testing COVID-19 criteria detection development diagnostic fungi Infection Laboratory limits MALDI-TOF MS mass MS test overcome pathogenic Population Population screening Proteins regulatory authority SAR-CoV-2 SARS-CoV-2 Screening Systems biology Test viral infection viral infections Viral protein virus viruses [DOI] 10.3390/v14091958 PMC 바로가기
Discovering common pathogenetic processes between COVID-19 and sepsis by bioinformatics and system biology approachArticle Published on 2022-08-312022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome addition Analysis approach bioinformatics Biomarker Blood caused clinical manifestations Clinical practice Coagulopathy Corona Coronavirus-2 COVID-19 Critically ill Critically ill patient Cytokine storm database DEGs demonstrated diagnostic differentially expressed differentially expressed gene differentially expressed gene (DEG) disease drug molecule enrichment analysis functional functional enrichment Gene Expression Omnibus gene expression profile Gene ontology gene regulatory network genetic link genetic mechanism GEO high mortality rate hub gene hypercoagulable Inflammatory response Interaction ITGAM molecular docking molecular mechanism multiple organ dysfunction neutrophil dysfunction pandemic Pathogenesis pathogenesis of COVID-19 pathway potential therapeutic agents progesterone protein-protein interaction Protein–protein interaction protein–protein interaction (PPI) receptor Regulatory Research respiratory infectious disease resulting risk SARS-CoV-2 screened Sepsis sepsis patient Septic shock severe COVID-19 signaling pathway similarity Spread syndrome System biology Systems biology Treatment were used with COVID-19 [DOI] 10.3389/fimmu.2022.975848 PMC 바로가기
Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysisCOVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석Meta-Analysis Published on 2022-08-032022-09-11 Journal: Molecular Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Accuracy acute respiratory illness acute respiratory illnesses Analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood [DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis
Organ-specific host differential gene expression analysis in systemic candidiasis: A systems biology approach전신 칸디다증에서 기관 특이적 숙주 차등 유전자 발현 분석: 시스템 생물학 접근법Article Published on 2022-08-012022-09-11 Journal: Microbial pathogenesis [Category] 유전자 메커니즘, [키워드] acquisition Activation acute phase response Analysis approach C. albicans can be used Candida Candida albican Candida albicans Candidemia candidiasis Clinical management Co-infection Complication coronavirus disease COVID-19 COVID-19 infections COVID-19 mortality Critical Defense defense mechanisms develop Differential gene expression differentially expressed gene Differentially expressed genes down-regulated drug effector cells event fungal infections hospital Host hub genes human gene human genes Immune cell immune cells immune response immune responses Infection Interaction invasive involved iron kidney leukocyte liver lymphocyte mechanisms molecular mycotic infection mycotic infections occur organ organ-specific organs pathway proliferation protocol recruitment research finding risk Scientific community severe COVID-19 infections sluggish spleen Surveillance systemic Candidiasis Systems biology therapeutic therapy yeast [DOI] 10.1016/j.micpath.2022.105677 PMC 바로가기 [Article Type] Article
The unmitigated profile of COVID-19 infectiousnessCOVID-19 전염성의 완화되지 않은 프로필Observational Study Published on 2022-08-012022-09-11 Journal: eLife [Category] SARS, 변종, [키워드] Alpha alpha and delta variants Analysis assumed China Computational biology COVID-19 delta variant early stage early stages Effectiveness Epidemics epidemiological Epidemiology estimate faster framework generation interval global health growth growth rate help Human individual infected individual infected individuals infected with SARS-CoV-2 infectiousness initial intervals Isolation Measures Mitigation outbreak pandemic quarantine quarantine measures robust SARS-CoV-2 sensitivity analysis spread of COVID-19 statistical Systems biology temporal dynamics thought Transmission variants variants of concern VOCs [DOI] 10.7554/eLife.79134 PMC 바로가기 [Article Type] Observational Study
Updated List of Transport Proteins in Plasmodium falciparumarticle Published on 2022-06-302024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] calcium homeostasis drug target malaria nutrient uptake Plasmodium falciparum Systems biology transport pathway transporters and channels [Article Type] article