ALVR109, an off-the-shelf partially HLA matched SARS-CoV-2-specific T cell therapy, to treat refractory severe COVID-19 pneumonia in a heart transplant patient: Case report심장 이식 환자의 난치성 중증 COVID-19 폐렴을 치료하기 위해 부분적으로 HLA와 일치하는 기성품인 SARS-CoV-2-특이적 T 세포 요법인 ALVR109: 사례 보고Case Reports Published on 2022-04-012022-09-11 Journal: American journal of transplantation : official jou [Category] COVID19(2023년), SARS, 변종, [키워드] Administered administration antibiotic: antiviral Antiviral benefit Cell therapy Clinical improvement clinical research/practice clinical trials Corticosteroids COVID-19 Day declined delta variant diagnosis of COVID-19 discharged Heart transplantation heart transplantation/cardiology High-flow nasal oxygen HLA immunobiology Immunosuppression improvement IND Infection infection and infectious agents-viral: SARS-CoV-2/COVID-19 infectious agents Infectious disease initial log low-flow oxygen male mycophenolate mycophenolate mofetil nasopharyngeal nasopharyngeal viral oxygen Patient Prednisone Quantitative rejection Remdesivir request rising RNA SARS-CoV-2 delta SARS-CoV-2 RNA Severe COVID-19 pneumonia subsequent T cell tacrolimus the patient therapy Tocilizumab transitioned treat treated undetectable variant Viral load [DOI] 10.1111/ajt.16927 PMC 바로가기 [Article Type] Case Reports
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposingSARS-COV-2 감염 및 약물 용도에 영향을 미치는 기능, 경로 및 조절제를 강조하는 숙주 게놈 바이오 마커의 계산 식별Article Published on 2022-03-112022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 신약개발, 치료제, [키워드] 3CL Analysis analyzed binding affinities Biomarker candidate drugs Computational biology and bioinformatics control sample COVID-19 CXCL2 daclatasvir DEGs differentially expressed gene docking drug Drug discovery drug target drugs Economy effective enrichment analysis FDA approved Drugs function functional functions genomic GUCY1A2 highlighting Host hub-genes identify IGF2 independent indicate infections Interaction investigated IRF7 Ivermectin KEGG pathway KLF6 life miRNA miRNAs molecular docking analysis NEDD9 network analysis PAG1 pandemic pathway Pathways performed PPI Protein Protein–protein interaction Proteins Radotinib Rapamycin receptor receptor protein receptor proteins receptors reduced RNA sequence SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven signaling pathway signaling pathways significantly SNRPD2 stability Stat1 Systems biology tacrolimus the SARS-CoV-2 Thiostrepton TLR2 transcriptomics Treatment USP53 vaccination variants of SARS-CoV-2 ZFP36 [DOI] 10.1038/s41598-022-08073-8 PMC 바로가기 [Article Type] Article
Tacrolimus Treatment for Post-COVID-19 Interstitial Lung DiseaseArticle Published on 2022-02-152023-07-07 Journal: Internal medicine (Tokyo, Japan) [Category] COVID19(2023년), [키워드] Coronavirus disease 2019 COVID19 immunosuppressive agent Interstitial lung disease Respiratory failure tacrolimus [DOI] 10.2169/internalmedicine.7971-21 PMC 바로가기
Undetectable triglycerides related to the combined intake of ascorbic acid and tacrolimusArticle Published on 2022-02-012023-07-08 Journal: Annales de biologie clinique [Category] COVID19(2023년), [키워드] antioxidant therapy ascorbic acid lipids lipoprotein lipase tacrolimus Vitamin C [DOI] 10.1684/abc.2022.1702
Absent antibody production following COVID19 vaccination with mRNA in patients under immunosuppressive treatments면역억제 치료를 받는 환자에서 mRNA로 COVID19 백신 접종 후 항체 생성 없음Article Published on 2021-12-172022-09-11 Journal: Vaccine [Category] MERS, SARS, 진단, 치료기술, [키워드] administration Analysis antibody antibody production Antibody testing B-cell booster vaccinations cellular coronavirus coronavirus disease COVID COVID19 depleting detectable dose evaluated fingolimod Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppressive treatment Infection Inflammatory inhibit lymphocyte maintain Measures metabolic disease Metabolic diseases mRNA ongoing therapies ongoing therapy Patient patients recipients respond responsiveness risk SARS-CoV-2 spike SARS-CoV-2 virus second dose solid organ solid organ transplant specific antibodies subunit T cell T cell proliferation tacrolimus the SARS-CoV-2 virus therapy vaccination Vaccine were measured [DOI] 10.1016/j.vaccine.2021.10.068 PMC 바로가기 [Article Type] Article
Long-Term Results of Triple Immunosuppression With Tacrolimus Added to Mycophenolate and Corticosteroids in the Treatment of Lupus NephritisClinical Research Published on 2021-12-142024-09-04 Journal: Kidney International Reports [Category] 대상포진, [키워드] long-term lupus nephritis mycophenolate tacrolimus triple [DOI] 10.1016/j.ekir.2021.12.005 PMC 바로가기 [Article Type] Clinical Research
Association Between Chronic Use of Immunosuppresive Drugs and Clinical Outcomes From Coronavirus Disease 2019 (COVID-19) Hospitalization: A Retrospective Cohort Study in a Large US Health SystemCoronavirus Disease 2019 (COVID-19) 입원 : 미국의 대규모 미국 건강 시스템에서의 후 향적 코호트 연구의 만성 사용 및 임상 결과 사이의 연관성Article Published on 2021-12-062022-08-31 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료제, [키워드] 95% CI 95% confidence interval Admission adults hospitalized chronic clinical Clinical outcome clinical outcomes cohort study coronavirus disease Coronavirus disease 2019 COVID-19 defined discharge drug entire cohort hazard ratio health system Hospital admission Hospital mortality Immunosuppressed Immunosuppression immunosuppressive drug immunosuppressive drugs IMPROVE in-hospital mortality individual interquartile range laboratory-confirmed mechanical ventilation mechanism median age Medicines mycophenolate mycophenolate mofetil no significant difference no significant differences Patient Prednisone prescription medicines. Prescriptions Probability Propensity score retrospective cohort study risk severity study period survived System tacrolimus the median Treatment with COVID-19 [DOI] 10.1093/cid/ciaa1488 PMC 바로가기 [Article Type] Article
Efficacy and Safety of Immunotherapies in Refractory Myasthenia Gravis: A Systematic Review and Meta-Analysisarticle Published on 2021-12-012024-09-02 Journal: Frontiers in Neurology [Category] 대상포진, [키워드] eculizumab (monoclonal antibody to C5) immunotherapies Refractory Myasthenia Gravis rituximab-ofatumumab-ibrutinib-idelalisib tacrolimus [DOI] 10.3389/fneur.2021.725700 PMC 바로가기 [Article Type] article
Undetectable SARS-CoV-2 active adaptive immunity-post-vaccination or post-COVID-19 severe disease-after immunosuppressants useSARS-CoV-2 능동 적응 면역-접종 후 또는 코로나19 이후 중증 질환-면역억제제 사용 후 검출 불가Case Reports Published on 2021-11-292022-09-11 Journal: BMJ case reports [Category] Coronavirus, SARS, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome adaptive Admission antibodies ARDS Care convalescent convalescent plasma COVID-19 COVID-19 pneumonia COVID-19 vaccination Dexamethasone died dissemination helping highlight IgG Immunity immunological immunological products and vaccines Immunosuppressant immunosuppressants Immunosuppressed immunosuppressed patient immunosuppressed patients Immunosuppression IMPROVE Infection infections Infectious diseases information malignant disease malignant disease and immunosuppression multiple sclerosis mycophenolate New nucleocapsid Ocrelizumab one patient Patient patients Pneumonia readmission Remdesivir renal reported required respiratory distress Respiratory distress syndrome Respiratory failure rituximab SARS-CoV-2 SARS-CoV-2 IgM secondary to Standard-of-care syndrome tacrolimus tested treated two patients ulcerative undetectable with COVID-19 worsening [DOI] 10.1136/bcr-2021-246308 PMC 바로가기 [Article Type] Case Reports
A single-center report of COVID-19 disease course and management in liver transplanted pediatric patients간이식 소아 환자의 COVID-19 질병 경과 및 관리에 대한 단일 센터 보고서Article Published on 2021-11-012022-09-11 Journal: Pediatric transplantation [Category] SARS, 치료기술, [키워드] absence Allograft Anakinra anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibiotic therapy antibody children Clinical and laboratory data collected COVID-19 COVID-19 diagnosis COVID-19 disease course COVID-19 symptom develop diagnosed disease severity electronic patient record Electronic patient records Everolimus Favipiravir Hyperactivation IL-6 immune system Immunocompromised Immunocompromised patient Immunocompromised patients Immunosuppression increased risk IVIG laboratory data liver liver transplant Liver transplantation lymphopenia management median median age MMF mounted Non-invasive not affect one patient Oxygenation Patient patients PCR positive PCR test Pediatric patient probable COVID-19 retained SARS-CoV-2 serum Serum IL-6 severe COVID-19 symptoms single-center solid organ Stopping Support survival tacrolimus therapy Treatment treatment guideline treatment guidelines virtue were used with COVID-19 written consent X-ray [DOI] 10.1111/petr.14061 PMC 바로가기 [Article Type] Article