Thromboinflammation – Page 3 – Communicable Diseases Research

Vascular Damage, Thromboinflammation, Plasmablast Activation, T-Cell Dysregulation and Pathological Histiocytic Response in Pulmonary Draining Lymph Nodes of COVID-19

COVID-19의 폐 배수 림프절에서 혈관 손상, 혈전 염증, 원형질모세포 활성화, T-세포 조절 장애 및 병리학적 조직구 반응

Immunology

Published on 2021-12-132022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료기술,

Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients

PBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다

Article

Published on 2021-12-012022-09-11
Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘,

[키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic
[DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article

Low-molecular-weight heparin use in coronavirus disease 2019 is associated with curtailed viral persistence: a retrospective multicentre observational study

코로나바이러스 질병 2019에서 저분자량 헤파린 사용은 바이러스 지속성 감소와 관련이 있습니다: 후향적 다기관 관찰 연구

Observational Study

Published on 2021-12-012022-09-10
Journal: Cardiovascular Research [Category] SARS, 바이오마커, 임상,

[키워드] (cfDNA) 95% confidence interval anticoagulation attenuation Biomarker cell death cell-free DNA cfDNA Chain Reaction Coagulopathy contraindications coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient COVID-19-associated coagulopathy D-dimer decrease different time point different time points Effect evaluate evaluated haemostasis hazard ratio heparin Hospitalization Hospitalized hospitalized COVID-19 patient hypercoagulability interquartile interquartile range LMWH Low-molecular-weight heparin marker mechanism Mortality multicentre multivariable Cox regression no effect NOAC oral anticoagulant outcome Patient patients with COVID-19 plasma polymerase chain polymerase chain reaction Quantitative quantitative polymerase chain reaction reduced reduction Region responsible retrospective SARS-CoV-2 viral persistence subset survival the cell Thromboinflammation time Viral viral persistence virus was collected
[DOI] 10.1093/cvr/cvab308 PMC 바로가기 [Article Type] Observational Study

Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications

COVID-19에서 혈소판 염증 및 내피 손상의 병원성 근거: 현재 연구 결과 및 치료적 시사점

Review

Published on 2021-11-082022-09-10
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] activities acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Atypical B cell responses Basis cardiovascular risk factors cause caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current dry cough dysregulated dysregulated immune responses Endothelial dysfunction endothelial injury exacerbated Fever finding global pandemic high mortality highlight immune evasion immune responses Inflammation interferon interferon signaling interstitial pneumonia knowledge leads mechanisms morbidity Most patients multiple organ failure Organ failure Pathogenesis pathogenesis of COVID-19 pathogenic patients platelet activation platelet hyperactivation public health respiratory respiratory distress resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe cases suppression symptoms of COVID-19 syndrome T cell therapeutic strategy Therapeutics Thromboembolism Thromboinflammation thrombosis
[DOI] 10.3390/ijms222112081 PMC 바로가기 [Article Type] Review

Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients

COVID-19 환자의 중기 사망률에 대한 조기 위험 계층화를 위한 순환 MR-proADM 수준, 내피 기능 장애의 지표

Observational Study

Published on 2021-10-012022-09-11
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 바이오마커, 임상,

[키워드] adrenomedullin Analysis assist association AUC Biomarker blood sample Coagulopathy complex interaction confounders contribute COVID-19 COVID-19 patient COVID-19 patients Cox regression Cutoff emergency department endothelial damage Endothelial dysfunction endotheliopathy Endpoint enrolled evaluated increased mortality independent Laboratory Laboratory test mid-regional proadrenomedullin Mortality mortality rate MR-proADM Negative predictive value observational study Patient physician Predictive value primary endpoint Prognosis Propensity score reported resulting risk stratification ROC AUC SARS-CoV-2 second wave sensitivity severity specificity surrogate thrombocytopathy Thromboinflammation were used
[DOI] 10.1016/j.ijid.2021.08.058 PMC 바로가기 [Article Type] Observational Study

Clinical applications of thrombopoietin silencing: A possible therapeutic role in COVID-19?

Review article

Published on 2021-10-012022-10-05
Journal: Cytokine [Category] SARS, 변종,

[키워드] affected clinical Coronavirus 2019 COVID-19 decrease indicate Inflammation inflammatory disorder megakaryocytes Novel coronavirus offer pathologic pathology Patient patients Platelet shown therapeutic Thromboinflammation Thrombopoietin Thrombopoietin silencing thrombosis TPO Treatment turn
[DOI] 10.1016/j.cyto.2021.155634 [Article Type] Review article

Thromboinflammation Supports Complement Activation in Cancer Patients With COVID-19

혈소판 염증은 COVID-19에 걸린 암 환자의 보체 활성화를 지원합니다

Immunology

Published on 2021-08-182022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커,

[키워드] accompanied Activation addition amyloid A analyzed C1-Inhibitor C3a C5a Cancer cancer patient Cancer patients cascade cascades circulating Coagulation complement Complement activation Complement inhibitor complement inhibitors conducted COVID-19 COVID-19 pathology D-dimer D-dimer level D-dimers described disease pathology dysfunction elevated Endothelial cell Endothelial dysfunction evaluate evaluated examined Factor FEU ICAM-1 increase Inflammation Inflammatory response inhibitors marker objective P-selectin Patient plasma platelet activation receptor Result SC5b-9 serum amyloid significantly increased soluble urokinase plasminogen activator receptor stratified Support systemic inflammation Thromboinflammation thrombomodulin Vascular Vascular damage with COVID-19
[DOI] 10.3389/fimmu.2021.716361 PMC 바로가기 [Article Type] Immunology

Autoantibodies stabilize neutrophil extracellular traps in COVID-19

자가 항체는 COVID-19에서 호중구 세포외 트랩을 안정화합니다

Research Article

Published on 2021-08-092022-09-10
Journal: JCI Insight [Category] MERS, SARS, 진단, 치료제,

[키워드] Adaptive immunity antibodies antibody associations autoantibodies autoantibody Autoimmunity circulating clearance contribute correlation COVID-19 COVID-19 sera D-dimer Degradation degrade demonstrated determine Efficiency fraction function functional greater healthy control healthy controls Hospitalized IgG IgG and IgM IgM immunopathology impair individual inherent inverse correlation Level mechanical ventilation NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils oxygen oxygen supplementation Oxygenation Patient patients purified required sera serum severe COVID-19 Thromboinflammation variety with COVID-19
[DOI] 10.1172/jci.insight.150111 PMC 바로가기 [Article Type] Research Article

Case Report: Co-occurrence of Myocarditis and Thrombotic Microangiopathy Limited to the Heart in a COVID-19 Patient

Cardiovascular Medicine

Published on 2021-07-292022-10-31
Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19,

Thromboinflammation in coronavirus disease 2019: The clot thickens

Review

Published on 2021-07-192022-10-04
Journal: British Journal of Pharmacology [Category] COVID19(2023년), Fulltext, MERS, SARS, 신약개발,