Thrombotic events – Page 3 – Communicable Diseases Research

Anti-phospholipid antibodies in the setting of thromboembolic events associated with severe COVID-19 pneumonia

Research

Published on 2022-01-182022-10-31
Journal: Egyptian Rheumatology and Rehabilitation [Category] COVID-19,

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Covid-19 (회복)로 병원에 입원 한 환자의 아스피린 : 무작위, 통제, 오픈 라벨, 플랫폼 시험

Randomized Controlled Trial

Published on 2022-01-082022-08-13
Journal: Lancet (London, England) [Category] 임상,

[키워드] (Medical Research Council) 1:1 95% CI absolute increase absolute reduction Accelerator allocation concealment Analysis anti-thrombotic properties Aspirin baseline bleeding composite endpoint COVID-19 death died discharge discharged duration of hospitalisation Efficacy and safety eligible enrolled evaluate finding funding hospital hospitalisation hospitalised hospitals in Indonesia hospitals in Nepal increase in Indonesia Innovation Intention intention to treat Invasive mechanical ventilation IQR ISRCTN major bleeding event major bleeding events median Medical Research Council Mortality Nepal no significant difference Open-label Patient per day Platform trial Primary outcome proportion randomisation randomised Randomly rate ratio receive RECOVERY trial reduction in reductions reductions in Registered risk risk ratio Standard of care subgroups of patients Therapeutics thrombotic thrombotic event Thrombotic events took place Treatment treatment for COVID-19 Trial usual care usual care alone web-based simple Wellcome Trust with COVID-19
[DOI] 10.1016/S0140-6736(21)01825-0 PMC 바로가기 [Article Type] Randomized Controlled Trial

Low in-hospital mortality rate in patients with COVID-19 receiving thromboprophylaxis: data from the multicentre observational START-COVID Register

혈전 예방을 받는 COVID-19 환자의 낮은 병원 내 사망률: 다기관 관찰 START-COVID Register의 데이터

Observational Study

Published on 2022-01-012022-09-12
Journal: Internal and Emergency Medicine [Category] MERS, 임상, 진단,

[키워드] Admission affected Antithrombotic Atrial fibrillation bleeding Cancer cause characteristic Cohort Comorbidities conducted COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient Deep vein Deep vein thrombosis dosage drug DVT enoxaparin fondaparinux heparin high mortality rate Hospital stay Hospitalized hospitalized patients hypertension in-hospital mortality rate interstitial pneumonia Italian low molecular weight low molecular weight heparin major bleeding majority Mortality mortality rate mortality rates multicentre multivariable multivariable analysis Neurological disease observational study outcome pathology Patient patients hospitalized patients older patients with COVID-19 Pulmonary embolism receive receiving reduction retrospective severe interstitial pneumonia significantly survival thromboembolic thromboembolic disease Thromboembolism Thromboprophylaxis thrombosis thrombotic thrombotic event Thrombotic events treated Treatment Venous Thromboembolism
[DOI] 10.1007/s11739-021-02891-w PMC 바로가기 [Article Type] Observational Study

Efficacy of the early treatment with tocilizumab-hydroxychloroquine and tocilizumab-remdesivir in severe COVID-19 Patients

중증 코로나19 환자에서 토실리주맙-히드록시클로로퀸 및 토실리주맙-렘데시비르 조기 치료 효과

Randomized Controlled Trial

Published on 2022-01-012022-09-12
Journal: Journal of infection and public health [Category] 임상, 진단, 치료제,

[키워드] Anti-inflammatory anti-inflammatory drug Antiviral both groups clinical clinical parameter cohort study Combination Complication contributed COVID 19 COVID-19 COVID19 CRP Cytokine storm dimer doses early treatment Effectiveness ferritin groups HCQ Hospitalization Hydroxychloroquine hyper inflammation ICU Infection infused interquartile range IQR laboratory investigation LDH mechanical ventilation mechanically ventilated patient median myocarditis no significant difference P/F PaO Patient PCR Randomized regimen Registered Remdesivir secondary bacterial infection severe COVID-19 significant decrease significantly TCZ Thrombotic events Tocilizumab Treatment treatment groups treatment regimen two group were assessed
[DOI] 10.1016/j.jiph.2021.10.024 PMC 바로가기 [Article Type] Randomized Controlled Trial

Report of Low Incidence of Thrombosis with Early Prophylaxis in Hospitalized Patients with COVID-19 from Two Saudi Tertiary Centers

Observational Study

Published on 2022-01-012022-10-05
Journal: Clinical and applied thrombosis/hemostasis : offic [Category] 임상,

[키워드] Administered administration Admission Admissions Anticoagulant anticoagulation center Cohort collected Comorbidities condition COVID-19 COVID-19 patients decrease demographics demonstrated determine different time point disease early administration eight evaluated event hematological hospital Hospitalized hospitalized COVID-19 ICU ICU admission ICU admission rate incidence Kingdom median time Mortality mortality rate Patient patients positive COVID-19 profile profiles Prophylactic Prophylaxis prospective observational study recorded reduce report risk risk factor Sample saudi Saudi Arabia shown subjects survival rate Symptom Tertiary tertiary care hospital Thromboembolism thrombosis thrombotic event Thrombotic events transfer VTE were recorded with COVID-19
[DOI] 10.1177/10760296221086286 PMC 바로가기 [Article Type] Observational Study

The incidence, clinical characteristics, and outcome of COVID-19 in a prospectively followed cohort of patients with Behçet’s syndrome

전향적으로 추적한 베체트 증후군 환자 코호트에서 COVID-19의 발병률, 임상적 특징 및 결과

Article

Published on 2022-01-012022-09-11
Journal: Rheumatology International [Category] 치료제,

[키워드] 95% CI adjusted age and gender Anosmia Anticoagulants arthralgia Asymptomatic Behcet's disease case sery Clinical characteristics Clinical outcome Cohort cohort of patient Colchicine Complete COVID-19 COVID-19 infection cumulative cumulative incidence defined died disease course dose drug discontinuation exacerbate fatigue Favipiravir Fever Follow-up followed by General population headache Hospitalized Hydroxychloroquine immunosuppressive incidence incidence of COVID-19 indicated infected with SARS-CoV-2 Infection information intensive care intensive care unit interferon interferon-alpha İstanbul laboratory-confirmed large cohort likelihood lung involvement management median Mortality Multiple Multiple regression analysis not differ outcome outpatient clinic pandemic Patient patients PCR positive positive Prognosis Prospective Study protective effect Registered regression analysis remaining reported SARS-CoV-2 SARS-CoV-2 PCR severity of COVID-19 Significant significantly smoking Symptom syndrome tested the patient thrombotic thrombotic event Thrombotic events took place Treatment Turkey were given
[DOI] 10.1007/s00296-021-05056-2 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis

SARS-CoV-2 스파이크 단백질은 미세혈관 항상성을 불안정하게 합니다.

Research Article

Published on 2021-12-222022-09-10
Journal: Microbiology Spectrum [Category] SARS, 유전자 메커니즘, 치료기술,

[키워드] ACE2 ACE2 expression Activation adverse effect adverse effects Affect alveolar alveolar epithelial cell Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin II Apoptosis Aspirin bind blunt bradykinin calcium Calcium signaling caspase cause caused Cell Cell signaling cells Coagulopathies complex Concentration contribute contributing to COVID-19 COVID-19 disease decreased expression downregulation dysfunction Effect Endothelial cell endothelial cells Endothelial dysfunction enzymatic activity enzyme epithelial epithelial cells event Evidence exposure expressed Factor homeostasis immunofluorescence microscopy in vitro model increased expression indicated infects Inflammation Interaction Interference Intervention Krüppel limit lung lung tissue lung tissues Lungs mechanism molecules organ dysfunction Pathogenesis pathology primary human cells pro-inflammatory molecules rationale receptor reduce reduced Respiratory function SARS-CoV-2 SARS-CoV-2 infected individuals SARS-COV-2 infection Signaling significantly spike Spike protein suggested tested these cell These cells thought thrombotic Thrombotic events understanding uninfected Vascular viability
[DOI] 10.1128/Spectrum.00735-21 PMC 바로가기 [Article Type] Research Article

Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?

COVID-19의 조기 진단 및 예후를 위한 thromogenicity markers: 현재 패러다임의 변화?

Observational Study

Published on 2021-12-012022-09-11
Journal: Blood coagulation & fibrinolysis : an internationa [Category] SARS, 바이오마커, 임상, 치료기술,

[키워드] Admission African Americans Analysis Biomarker Comparisons composite endpoint COVID-19 COVID-19 diagnosis COVID-19 negative COVID-19 patient COVID-19 patients COVID-19 positive patient COVID-19 positive patients death diabete diabetes diagnostic early diagnosis FCS FDA FIBRIN fibrin clot fibrinogen functional Guidance Hospitalization hospitalized COVID-19 Hypothesis identify In-hospital less marker Metrics MOST Multivariate analysis Myocardial infarction negative patients observation observational study Occurrence on admission Organ failure outcome Patient patients positive positive patient positive patients Prognosis prognostic Prospective Study Sequential Organ Failure Assessment SOFA SOFA score Standard stroke suggested Support thromboelastography Thromboembolism thrombogenicity thrombotic thrombotic event Thrombotic events utility were recorded Whole blood with COVID-19
[DOI] 10.1097/MBC.0000000000001069 PMC 바로가기 [Article Type] Observational Study

Mechanisms of thrombosis in ANCA-associated vasculitis

ANCA 관련 혈관염에서 혈전증의 기전

Review

Published on 2021-12-012022-09-11
Journal: Clinical Rheumatology [Category] MERS, SARS, 바이오마커, 진단, 치료기술,

[키워드] Activated neutrophils Activation anti-neutrophil cytoplasmic antibody Anti-neutrophil cytoplasmic antibody-associated vasculitis antibodies antibody antiphospholipid antibodies antiphospholipid antibody APL Blood caused circulation clotting cocaine contribute coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic Deep vein Deep vein thrombosis described driving drug Embolism Embolism and thrombosis endothelial injury Endothelium ENhance expressing Extracellular greater homeostatic hydralazine Injury Levamisole mechanism Microparticle NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils occur pandemic pathogenic Patient Propylthiouracil Remission report resulting risk thrombi thrombogenesis thrombosis thrombotic thrombotic event Thrombotic events tissue Tissue Factor Trigger Vascular endothelium Vasculitis venous
[DOI] 10.1007/s10067-021-05790-9 PMC 바로가기 [Article Type] Review

Hormonal Contraception and Massive Pulmonary Embolism in a COVID-19 Ambulatory Patient: A Case Report

Case Report

Published on 2021-11-262022-10-31
Journal: Clinics and Practice [Category] COVID-19,