Identification of Potential SARS-CoV-2 Main Protease and Spike Protein Inhibitors from the Genus Aloe : An In Silico Study for Drug DevelopmentArticle Published on 2021-03-212022-10-30 Journal: Molecules [Category] COVID-19, SARS, [키워드] Aloe acute respiratory syndrome addition Aloe antiviral activity binding free energy biological activities Complication Compound coronavirus COVID-19 development deviation disease docking drug Drug discovery drug-likeness effective fluctuation genus help highest identification identify in silico Approach indicated inhibitor investigated main protease MD simulation molecular docking Molecular dynamics simulation Mortality pharmacokinetic Potential protease Protein Result retrieved RMSD RMSF root SARS-CoV-2 specific treatment spike spike glycoprotein Spike protein stability suggested the disease these compound Till virus [DOI] 10.3390/molecules26061767 PMC 바로가기 [Article Type] Article
Plant Products as Inhibitors of Coronavirus 3CL ProteasePharmacology Published on 2021-03-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 3-chymotrypsin-like cysteine protease 3CL 3CL pro antiviral activity antiviral drug approved article clinical trial collected coronavirus Coronavirus disease 2019 Coronavirus replication COVID-19 COVID-19 pandemic cysteine protease drug Drug discovery exhibited expected global health security Google Scholar inhibit lack main protease plant plant products plant-derived 3CLpro inhibitors plants polyprotein product protease Psoralea reached reported Rheum SARS-CoV-2 specific treatment therapeutic Till Topic Torreya nucifera Vaccine were excluded were used [DOI] 10.3389/fphar.2021.583387 PMC 바로가기 [Article Type] Pharmacology
An Update on Antiviral Therapy Against SARS-CoV-2: How Far Have We Come?Pharmacology Published on 2021-03-082022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] affecting Against Analysis anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antibiotics antiviral drugs antivirals approach approved drug Candidates Chloroquine Clinical efficacy Clinical findings clinical study clinical trial clinically Complete conducted Convalescent plasma therapy Corticosteroid COVID-19 COVID-19 pandemic COVID-19 patients drug Drug repurposing Drug-drug interactions drugs effective Effectiveness evaluate Favipiravir Hydroxychloroquine identify International limitation Long-term follow-up Lopinavir-ritonavir Lung inflammation mechanism mechanism of action Open-label oseltamivir pharmacokinetics Placebo Population Randomized randomized clinical trial recorded reduce regimens regions Registered Remdesivir Repurposed drug Research ribavirin SARS-CoV-2 Spread therapeutic Till treat Treatment Trial umifenovir virus were used WHO [DOI] 10.3389/fphar.2021.632677 PMC 바로가기 [Article Type] Pharmacology
Inhibitory efficiency of potential drugs against SARS-CoV-2 by blocking human angiotensin converting enzyme-2: Virtual screening and molecular dynamics study인간 안지오텐신 전환 효소-2를 차단하여 SARS-CoV-2에 대한 잠재적 약물의 억제 효율: 가상 스크리닝 및 분자 역학 연구Article Published on 2021-03-012022-08-31 Journal: Microbial pathogenesis [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 ACE-2 receptor Analysis angiotensin anti-bacterial anti-viral drug Anti-viral drugs best bind binding affinity binding site block blocking Cefpiramide comprehensive analysis COVID-19 CPM drug effective Efficiency enzyme gyration highest binding affinity human Angiotensin-converting enzyme molecular molecular docking molecular dynamics Molecular dynamics simulation parameter radius of gyration receptor RMSD RMSF SARS-CoV-2 SARS-CoV-2 spike protein screened selected solvent Spike protein surface area Till Vaccine virus [DOI] 10.1016/j.micpath.2021.104762 PMC 바로가기 [Article Type] Article
Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approachesSARS-COV-2에 대한 차세대 멀티에피토프 기반 백신(MEV) 설계: 면역정보학 및 인실리코 접근법Research Article Published on 2020-12-222022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] adjuvant Amino acid amino acids analyses antigenic antigenic proteins approach B-cell binding affinity caused conducted coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 demonstrated effective epitope Epitopes Escherichia coli Escherichia coli K-12 system flexible followed by global health security highly antigenic HLA-binding allele HLA-binding alleles human pathogenic toll-like receptors immunogenic profile in silico In silico cloning increased expression indicated K-12 linker MEV MEV codon MEV codons MEV construct MHC class MHC class I MHC class II epitopes molecular molecular docking molecular dynamics multiepitope based vaccine non-allergenic overlapping pandemic pathogenic predicted Protein respiratory Respiratory Coronavirus selected Selected epitopes severe acute respiratory coronavirus significant interaction T-cell target targets Till TLR TLR3 TLR8 Toll-like receptor Vaccine vaccine against SARS-COV-2 vaccine production [DOI] 10.1371/journal.pone.0244176 PMC 바로가기 [Article Type] Research Article
Controlling the Outbreak of COVID-19: A Noncooperative Game PerspectiveSocial Implications of Technology Published on 2020-11-262022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] Analysis approach controlling COVID-19 decrease effective Effectiveness Epidemic feature game health economics help Home isolation increase individuals Isolation lockdown Nash equilibrium noncooperative game outbreak pandemic Prevent preventive measure promote social distancing spread of COVID-19 Till [DOI] 10.1109/ACCESS.2020.3040821 PMC 바로가기 [Article Type] Social Implications of Technology
Combating the Pandemic COVID-19: Clinical Trials, Therapies and PerspectivesMolecular Biosciences Published on 2020-11-172022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome addition antiviral drug approach caused claimed clinical Clinical studies clinical trial Convalescent plasma therapy coronavirus Coronavirus disease-19 Coronavirus-2 COVID-19 database Direct drug Drug repurposing Ebola evidenced globe in silico in vitro Infection Influenza measure MERS-CoV pandemic Potential Prophylaxis provide provided Registered RNA virus SARS-CoV SARS-CoV-2 Science systematic review Therapeutic approach therapy Till Treatment treatment strategy unique Vaccine [DOI] 10.3389/fmolb.2020.606393 PMC 바로가기 [Article Type] Molecular Biosciences
Potential of electric stimulation for the management of COVID-19COVID-19 관리를 위한 전기 자극의 가능성Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] 치료제, [키워드] adjuvant antiviral drugs approved boost immunity clinically COVID-19 COVID-19 pandemic drug effective Electric stimulation Evidence functions globe growth health emergency Human Hypothesis Immunity IMPROVE inhibit SARS-CoV-2 management outcome Pain pandemic penetration Potential reduce Research respiratory Respiratory function respiratory functions significantly symptomatic symptomatic therapies the disease therapeutic therapeutic options therapy Till Treatment treatment regimen unavailability Vaccine [DOI] 10.1016/j.mehy.2020.110259 PMC 바로가기 [Article Type] Article
It Ain’t Over Till It’s Over: The Triple Threat of COVID-19, TB, and HIVEditorial Published on 2020-10-312022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS, [키워드] COVID-19 HIV over threat Till [DOI] 10.4269/ajtmh.20-1089 PMC 바로가기 [Article Type] Editorial
Systematic Review and Pharmacological Considerations for Chloroquine and Its Analogs in the Treatment for COVID-19Pharmacology Published on 2020-10-282022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Administered ADRS Adverse reaction anti-malarial drug approved China Chloroquine clinical trial clinician COVID-19 COVID-19 patients curative demonstrated disease drug effective Efficacy Efficacy and safety HCQ heterogeneity Hydroxychloroquine induce Meta-analysis pandemic pharmacokinetic characteristics pharmacological pharmacological considerations Piperaquine pregnancies Registered review SARS-coronavirus Side effect significantly Spread Till Tolerability unique WHO [DOI] 10.3389/fphar.2020.554172 PMC 바로가기 [Article Type] Pharmacology