SARS-CoV-2 Seroconversion in Response to Infection and Vaccination: a Time Series Local Study in BrazilArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome age Analysis anti-Spike IgG antibody Antigen Brazil coronavirus coronavirus disease COVID-19 COVID-19 vaccination determine effective Effectiveness Fatality rate fraction Gender help humoral IgG Infection infection rate information nucleocapsid nucleocapsid antigen pandemic progression raised reactive response response to vaccination SARS-CoV-2 SARS-COV-2 infection Seroconversion seroconversion rate seroconvertion serological serological data serological survey Seroprevalence Sery spike Support the disease the SARS-CoV-2 time vaccination vaccine dose [DOI] 10.1128/spectrum.01026-22 PMC 바로가기
Optimal Timing of Remdesivir Initiation in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) Administered With Dexamethasone덱사메타손을 투여한 2019 코로나바이러스 질환(COVID-19) 입원 환자에서 렘데시비르 시작의 최적 시기Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] 95% CI acute respiratory distress addition applied benefit Clinical improvement Cohort coronavirus disease COVID-19 Cox regression models cumulative Dexamethasone difference drug exposure group Follow-up group hazard ratio Hong Kong hospital Hospital stay Hospitalization Hospitalized HRs IgG antibody In-hospital death increased risk initiated Initiation Length of hospital stay lower risk Multiple outcome Patient patients with moderate positive Probability progression Remdesivir significantly shorter Survivors syndrome time time to clinical improvement. Treatment Weighting were given WHO [DOI] 10.1093/cid/ciab728 PMC 바로가기 [Article Type] Article
Real-world effectiveness of early molnupiravir or nirmatrelvir–ritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong’s omicron BA.2 wave: a retrospective cohort studyResearch article Published on 2022-08-242022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 1:1 Abstract Admission all-cause mortality analysed Antiviral Antiviral treatment authority calculated Chinese clinical benefit contraindication Control controls COVID-19 COVID-19 diagnosis Cox regression models Cycle threshold value Department diagnosis of SARS-CoV-2 Disease progression Effectiveness eligible evaluate event exclusion finding Follow-up for inclusion funding hazard ratio Hong Kong hospital hospitalised hospitalised patient HRs ICU admission IMV incidence rate Infection intensive care Invasive mechanical ventilation lower risk material Mild-to-moderate molnupiravir need for oxygen oral outcome outcomes Oxygen therapy pandemic Patient patients Primary outcome recipient Region registry renal required retrospective cohort retrospective cohort study RT-PCR SARS-CoV-2 SARS-COV-2 infection secondary outcome severe liver impairment Significant significantly shorter study period supplemental oxygen Support symptom onset therapy time translation viral burden virological outcome were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00507-2 [Article Type] Research article
Flipped Inflammatory Time and the Role of Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2: Optimizing Tocilizumab Against Coronavirus Disease 2019뒤집힌 염증 시간과 중증 급성 호흡기 증후군에 대한 항체의 역할 코로나바이러스 2: 코로나바이러스 질병 2019에 대한 토실리주맙 최적화Article Published on 2022-08-122022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission Against Anti-inflammatory effects autoantibodies benefit Complication coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 disease dose driven by highest IL-6 IL-6 inhibition IL-6 inhibitor IL-6 inhibitors Immunopathogenesis inhibitor inhibitors innate immune system interferon interleukin mechanism of action modulate Mortality Open-label Patient Platform trial predict proinflammatory question Randomized respiratory risk role SARS-CoV-2 SARS-COV-2 infection Seroconversion seroconvert serostatus severe acute respiratory syndrome Coronavirus severe COVID-19 Spike protein subgroup of patient therapy time Tocilizumab Treatment [DOI] 10.1093/infdis/jiac090 PMC 바로가기 [Article Type] Article
Modeling Global COVID-19 Dissemination Data After the Emergence of Omicron Variant Using Multipronged Approaches다각적 접근 방식을 사용하여 오미크론 변이체 출현 후 글로벌 COVID-19 보급 데이터 모델링Article Published on 2022-08-102022-09-11 Journal: Current microbiology [Category] SARS, 변종, [키워드] among others approach basic Behavior collected compartmental model country COVID-19 COVID-19 dissemination COVID-19 pandemic data set data sets determine develop disease spread distribution drop emergence Factor fitting followed by Formula human behavior incidence increase in Infection infection rate infection rates information Interpretation management measure modeling number omicron pandemic reproduction Research Sery Spread statistical text the disease time Transmission vaccination vaccination efficacy variants of SARS-CoV-2 vulnerable population yielding [DOI] 10.1007/s00284-022-02985-4 PMC 바로가기 [Article Type] Article
2-deoxy-D-glucose as an adjunct to standard of care in the medical management of COVID-19: a proof-of-concept and dose-ranging randomised phase II clinical trialClinical Trial Published on 2022-08-042022-10-04 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] 2-deoxy-D-glucose 2-DG acute COVID-19 addition Administered adverse event age analyzed approach clinical benefit clinical recovery clinical study clinical trial conducted COVID-19 CTRI discharge dose efficacious therapeutic Efficacy Efficacy and safety evaluate evaluated hazard In-vitro intensive care Isolation limit management median metabolic inhibitor Mild moderate Mortality Negative conversion Normalisation Open-label outcomes Patient progression randomised randomised clinical trial Randomized receive reported RT-PCR SARS-CoV-2 severe COVID-19 severe COVID-19 patients shown significantly shorter standard care Standard of care time Tolerability treated Treatment Trial vital sign WHO [DOI] 10.1186/s12879-022-07642-6 PMC 바로가기 [Article Type] Clinical Trial
Impact of Severe Acute Respiratory Syndrome Coronavirus 2-Induced COVID-19 on Fixed Operating Room Times in Urologic OperationsResearch article Published on 2022-08-012022-10-05 Journal: Mayo Clinic Proceedings: Innovations, Quality & Outcomes [Category] 치료기술, [키워드] 48 hour acute respiratory syndrome AGSartificial genitourinary sphincter anesthesia-release to cut time ARCTanesthesia-release to cut time artificial genitourinary sphincter caused CIconfidence interval close to wheels-out time collected confidence interval coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 CTWOclose to wheels-out time Efficiency evaluate examined fixed group Impact impacted in-room to anesthesia-release time in-room to cut time include interquartile range IQRinterquartile range IRATin-room to anesthesia-release time IRCTin-room to cut time objective Operating room operation ORoperating room over Patient polymerase chain respiratory Result room SARS-CoV-2severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 time variable was used Wilcoxon rank sum [DOI] 10.1016/j.mayocpiqo.2022.06.002 [Article Type] Research article
Colon cancer treatment in Sweden during the COVID-19 pandemic: A nationwide register-based studyObservational Study Published on 2022-08-012022-10-05 Journal: Colorectal disease : the official journal of the A [Category] 임상, [키워드] 30-Day mortality adverse effect Cancer cancer treatment Chemotherapy Colon cancer Colorectal Colorectal cancer Colorectal surgery complications COVID-19 COVID-19 pandemic diagnose diagnosed Diagnosis Elective surgery no difference no increase observé Ostomy outcome pandemic Patient proportion reduced registry surgery pandemic. surgical Swedish time treat treated Treatment [DOI] 10.1111/codi.16129 PMC 바로가기 [Article Type] Observational Study
Clinical and genomic signatures of SARS-CoV-2 Delta breakthrough infections in New York뉴욕에서 SARS-CoV-2 Delta 획기적인 감염의 임상 및 게놈 서명Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] adaptive age Alpha Analysis Breakthrough infection breakthrough infections center circulating variant circulating variants clinical clinical variables confounders contributed controls COVID-19 hospitalization death Delta determinant distribution Epidemic Genome genomic Genomic signatures of vaccine breakthrough growth Hospitalization increasingly individuals Infection Isaac Mutation network network analysis Network analysis of clinical variables New York Nsp12 occurred parameters Phylogenetic predominant prevented profiles SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variant of concern (VOC) delta Selective adaptation significantly spike spike mutation Spike S112L and nsp12 F192V Support supported technology time Time since vaccination. vaccination Vaccine vaccine breakthrough infection vaccine breakthrough infections viruses VoC while [DOI] 10.1016/j.ebiom.2022.104141 PMC 바로가기 [Article Type] Article
ESKAPE bacteria characterization reveals the presence of Acinetobacter baumannii and Pseudomonas aeruginosa outbreaks in COVID-19/VAP patientsResearch article Published on 2022-08-012022-10-05 Journal: American journal of infection control [Category] 변종, 치료기술, [키워드] Acinetobacter Analysis association Bacteria Bacteria ESKAPE Care classical Clonal dispersion COVID-19 COVID-19 pandemic COVID-19 patient Critical decrease epidemiological Epidemiology ERIC-PCR ESKAPE First wave hidden intergenic region involved isolate MDR molecular multidrug-resistant outbreak P. aeruginosa Patient patients PCR phenotype Pseudomonas aeruginosa reduced resistance Result reveal Surveillance susceptibility time timelines VAP Ventilator associated pneumonia was performed [DOI] 10.1016/j.ajic.2022.08.012 [Article Type] Research article