Gene Network Analysis of the Transcriptome Impact of SARS-CoV-2 Interacting MicroRNAs in COVID-19 DiseaseCOVID-19 질병에서 SARS-CoV-2 상호작용 MicroRNA의 전사체 영향에 대한 유전자 네트워크 분석Review Published on 2022-08-172022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] affected Analysis biochemical biological processes Cell cell cycle cell surface receptor changes characterized COVID-19 COVID-19 disease cytokine death DEGs differentially expressed differentially expressed gene Differentially expressed genes downregulated exploratory FIVE functional enrichment Functional enrichment analysis Gene Expression gene network Health Organization heart Impact involved kidneys list lung Lymph node microRNA MicroRNAs mitochondrial mitotic mitotic cell modulation molecular Multiorgan multiorgan disease network network analysis pathological mechanism Pathways Perspective predicted provide reported SARS-CoV-2 SARS-CoV-2 virus signaling pathway submitted surface receptor target tissue tissues transcriptomes translated upregulated WHO with COVID-19 World Health Organization [DOI] 10.3390/ijms23169239 PMC 바로가기 [Article Type] Review
Passive immunization with equine RBD-specific Fab protects K18-hACE2-mice against Alpha or Beta variants of SARS-CoV-2Article Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] ACE2 receptor binding addition administration antibody Beta clearance contributed country COVID-19 COVID-19 pandemic creating delta variant disease dose doses Efficacy emergence EpF(ab’)2 equine Equine F(ab’)2 Fab HBsAg immunization implementation increased survival Infection intranasal K18-hACE2 K18-hACE2 transgenic mice mice monoclonal antibody treatment neutralize omicron outcome pandemic passive immunization peripheral circulation phenotype polyclonal polyclonal antibodies PROTECT RBD SARS-CoV-2 SARS-COV-2 infection Severe case severe disease severe SARS-CoV-2 strain survival tested therapeutic Therapeutic treatment tissues transgenic Treatment variant variant of concern (VOC) variants variants of concern variants of SARS-CoV-2 Viral RNA virus VoC [DOI] 10.3389/fimmu.2022.948431 PMC 바로가기
Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents인간 폐 상피 조직 동등물에서 SARS-CoV-2 및 인플루엔자 감염 및 항바이러스 치료 모델링Article Published on 2022-08-122022-09-11 Journal: Communications Biology [Category] SARS, 바이오마커, 진단, 치료기술, 치료제, [키워드] alveolar Analysis antiviral drug Antiviral treatment antiviral treatments Biomarker cell type cell types cellular chemokine class Critical CXCL10 cytokine Cytokine storm develop emerging viruses epithelial exhibiting human lung IAV IFN response IL-10 IL-6 in vitro in vivo include infect Infection infections Influenza influenza A influenza A virus influenza infection MHC MHC class I modeling Pathogens peaking pharmacological platform Replication robust SARS-CoV-2 SARS-COV-2 infection severe SARS severe SARS-CoV-2 Single-cell RNA sequencing throughput tissue tissues tracheobronchial Validity Viral viral infection virus viruses [DOI] 10.1038/s42003-022-03753-7 PMC 바로가기 [Article Type] Article
Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infectionResearch article Published on 2022-08-082022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 바이오마커, [키워드] Applying AUROC Biomarker Biomarkers Blood blood transcriptome change characteristic chose Cluster Co-infection collected combinations confidence interval COVID-19 COVID-19 infection COVID-19 pandemic dataset defined DEGs differentially expressed disorder dysfunction early-onset eligible endothelial event experiments explained expressed identify independent Infection information interferon Intervention IRF6 ITGA5 machine learning males mechanism MOST overlapped P2RX7 pandemic placental positive predict predicted Predictive predictor preeclampsia Pregnancy proportion Regulatory representing Result selected severe COVID-19 significantly tissue tissues transcript Transcriptome was determined with COVID-19 Z-score [DOI] 10.1016/j.csbj.2022.08.011 [Article Type] Research article
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC)COVID-19의 긴 COVID/급성 후유증(PASC)을 가진 개인의 증상, 동반질환, 섬유소 아밀로이드 미세응고 및 혈소판 병리의 유병률Article Published on 2022-08-062022-09-11 Journal: Cardiovascular Diabetology [Category] SARS, 진단, 치료기술, [키워드] accompanied acute COVID-19 African amyloid Amyloid fibrin(ogen) analysed Atypical balance blood sample Blood samples Brain capillary cardiovascular disease cholesterol Clinical studies clinical study Clinical treatment co-morbidities Comorbidities Comorbidity comparable Concentration controlled clinical studies coronavirus coronavirus 2019 disease COVID-19 COVID-19 severity determine diabetes Diabetes Mellitus Diagnostic method Diversity dyslipidaemia Early detection effective Efficacy endotheliopathy fatigue female FIBRIN Fluorescence fluorescence microscopy foci Gender Hyperactivated platelets hypertension individual inhibit joint Long Long COVID/PASC morbidities muscle pains ogen PASC pathology Patient patients Platelet platelet hyperactivation Platelets platform provide reducing registry removal reported reversal SARS-COV-2 infection scoring system Shortness of breath South Symptom Symptoms tissues Transport Treatment type 2 diabete Type 2 diabetes mellitus [DOI] 10.1186/s12933-022-01579-5 PMC 바로가기 [Article Type] Article
High-throughput proteomic sample preparation using pressure cycling technology Protocols Published on 2022-08-052022-10-05 Journal: Nature protocols [Category] 바이오마커, [키워드] Analysis analyzed atmospheric cells Cycling digestion effective eight formalin-fixed paraffin-embedded kidney tissue lysis buffer peptide Protein proteolytic proteomic proteomics protocol resulting robust specimen tissue tissues tumors [DOI] 10.1038/s41596-022-00727-1 [Article Type] Protocols
Assessing and improving the validity of COVID-19 autopsy studies – A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analysesResearch article Published on 2022-08-022022-10-05 Journal: EBioMedicine [Category] Coronavirus, SARS, 치료기술, [키워드] Alliance Analysis antibody approach Assessing Autopsy autopsy study available data Berlin cell line cellular structure center correlated COVID-19 criteria education Effect Effects electron microscopy evaluated finding foundation funding Guidance help high variability highest IHC immune response immunohistochemistry Interpretation Microscopy Ministry of Health multicentre organ organ damage pathology pathophysiology positive correlation Protein provided Quantitative recommendation reproducibility RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 viral RNA Sensitivity and specificity specificity the SARS-CoV-2 tissue tissues university Validity Variability Viral protein virus [DOI] 10.1016/j.ebiom.2022.104193 [Article Type] Research article
Genetic alterations, RNA expression profiling and DNA methylation of HMGB1 in malignancies악성 종양에서 HMGB1의 유전적 변경, RNA 발현 프로파일링 및 DNA 메틸화Article Published on 2022-08-012022-09-11 Journal: Journal of Cellular and Molecular Medicine [Category] 바이오마커, [키워드] alterations analysed Analysis B-cell lymphoma bioinformatics Biomarker cancers COVID-19 Covid-19 biomarker diffuse large B-cell lymphoma DNA methylation evaluate expression Genetic Genetic variation HMGB1 human cancer human cancers human diseases lymphoid malignancy neoplasm overexpressed pan-cancer. pancreatic positive correlation Prognosis reported RNA expression survival therapeutic target thymoma tissues Tumours [DOI] 10.1111/jcmm.17454 PMC 바로가기 [Article Type] Article
RNA solutions to treat inborn errors of metabolism신진대사의 선천적 오류를 치료하기 위한 RNA 솔루션Review Published on 2022-08-012022-09-11 Journal: Molecular genetics and metabolism [Category] 유전자 메커니즘, [키워드] activating antisense Antisense oligonucleotides approved Biology Chemistry Clinical efficacy clinical trial clinical trials Clinical use COVID-19 drug drugs effective expression gene silencing help IEM include lncRNA mechanism mechanism of action messenger RNAs metabolism MicroRNAs molecules mRNA mutations New offer overcome Patient pharmacokinetic rare disease rare diseases Research RNA RNA interference RNA vaccine RNA vaccines RNAs siRNA splicing Stage suppress target tissues Therapeutic approach therapy tissues treat [DOI] 10.1016/j.ymgme.2022.07.006 PMC 바로가기 [Article Type] Review
Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses코로나바이러스 및 기타 호흡기 바이러스에 감염된 인간 폐 세포에서 HLA-B 발현의 대립형질 불균형Article Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] SARS, 변종, 유전자 메커니즘, [키워드] accompanied allelic Analysis Antigen Antiviral association cells characterized contribute coronavirus cytokine Diseases epithelial cells experimental evidence expression genotypes heterozygous HLA HLA allele HLA alleles HLA-B human lung human lung cell human lung epithelial cells IFNβ in silico independent data set infected with SARS-CoV-2 less leucocyte loci lung cell lung cells other respiratory virus overexpression performed predicted respiratory viral infection respiratory viral infections respiratory virus RNA-seq data SARS-CoV-2 tissues viral infectious disease viral infectious diseases with COVID-19 [DOI] 10.1038/s41431-022-01070-5 PMC 바로가기 [Article Type] Article