Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study브라질에서 2회 용량 1차 프로토콜 및 BNT162b2 이종 부스터(Immunita-001)에서 비활성화된 바이러스(CoronaVac) 백신의 면역원성, 효과 및 안전성: 1년 기간의 후속 조치 4상 연구Clinical Trial Published on 2022-06-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike anti-Spike IgG anti-spike IgG antibodies Anti-spike IgG antibody antibody antibody levels Antibody titer Antibody titers approach association BNT162b2 booster booster dose Brazil Cellular immune response chemokines CoronaVac coronavirus COVID-19 COVID-19 pandemic Critical Cytokines Delta delta variant dose Effectiveness exposure to followed by growth factor Growth factors Heterologous heterologous booster highest IgG immune Immune profile immune response immunogenicity implication individual individuals Interaction maintenance male median mediators Neutralising Antibodies neutralising antibody no increase omicron Omicron variant pandemic Period phase 4 presenting protocol reduction remained respiratory restored robust Safe Safety SARS-CoV-2 Seropositivity severe acute respiratory syndrome Coronavirus significantly Spread timepoint titer titers vaccination Vaccine variant virus Year [DOI] 10.3389/fimmu.2022.918896 PMC 바로가기 [Article Type] Clinical Trial
[Vaccines against coronavirus disease 2019 (COVID-19) : Efficacy comparison, safety aspects, and current challenges][2019 코로나바이러스 감염증(COVID-19) 예방백신 : 효능비교, 안전성 측면 및 당면과제]Review Published on 2022-06-012022-09-11 Journal: Innere Medizin (Heidelberg, Germany) [Category] MERS, 변종, 진단, [키워드] activated Adaptability adjuvant adjuvants adverse effects CD4 CD4+ cellular children coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccines COVID-19 vaccines/adverse effects disadvantage Disadvantages English Formulation humoral Humoral immunity Immunity, cellular Immunity, humoral Immunocompromised patients Immunosuppression mRNA vaccines myocarditis Neutralizing antibodies neutralizing antibody pandemic patients physicochemical pregnant women Spectrum Spike protein stability the spike protein thrombotic Thrombotic thrombocytopenia titer vaccination Vaccine vector Viral Viral variants [DOI] 10.1007/s00108-022-01325-9 PMC 바로가기 [Article Type] Review
Early administration of COVID-19 convalescent plasma with high titer antibody content by live viral neutralization assay is associated with modest clinical efficacy살아있는 바이러스 중화 분석에 의한 고역가 항체 함량을 가진 COVID-19 회복기 혈장의 조기 투여는 보통의 임상 효능과 관련이 있습니다Article Published on 2022-06-012022-09-11 Journal: American journal of hematology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absolute reduction administration administration of CCP antibody Antibody titer benefit CCP clinical benefit Clinical efficacy convalescent plasma correlation COVID-19 COVID-19 convalescent plasma Cox regression death rate death rates determined by develop Dilution Efficacy evaluate evaluated Hospitalization hospitalized patient hospitalized patients inhibitory intubated patients multivariable Cox regression neutralized Neutralizing antibody titer Non-intubated non-intubated patient non-intubated patients Patient receiving Risk factors shown stratified titer transfused Treatment two groups Viral viral neutralization viral variant Viral variants was performed with COVID-19 [DOI] 10.1002/ajh.26531 PMC 바로가기 [Article Type] Article
Immune Response 5-7 Months after Vaccination against SARS-CoV-2 in Elderly Nursing Home Residents in the Czech Republic: Comparison of Three Vaccines체코의 노인 요양원 거주자의 SARS-CoV-2 예방 접종 후 5-7개월의 면역 반응: 3가지 백신의 비교Article Published on 2022-05-182022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval anti-S IgG antibody appear approach AstraZeneca booster dose cellular cellular immunity completion complex convalescent correlated Course COVID-19 elderly elderly nursing home residents evaluated expected home Humoral immunity IgG antibodies IgG antibody immune parameter immune response Immunity individual interferon matter Moderna Month neutralization capacity nucleocapsid protein Nursing nursing home occurred omicron participant patients Pfizer positive positive result Prevalence resident response Result sampling SARS-CoV-2 SARS-COV-2 infection significantly higher Spike protein subset tested titer took place vaccination Vaccine Vaccines Virus neutralization was reduced [DOI] 10.3390/v14051086 PMC 바로가기 [Article Type] Article
Humoral Immune Response Diversity to Different COVID-19 Vaccines: Implications for the “Green Pass” Policy다양한 COVID-19 백신에 대한 체액 면역 반응 다양성: "그린 패스" 정책에 대한 시사점Article Published on 2022-05-112022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] ACE2 binding activities Ad26 Ad26.COV2.S age Analysis anti-RBD anti-RBD antibody titer antibody Antibody Response Antibody titer appear assumption average binding BNT162b2 booster vaccination ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine ChAdOx1 nCoV-19 vaccines concentrations country COV2.S COVID-19 COVID-19 infection COVID-19 pandemic detect Diversity elicit elicited eligibility epitope evaluated Features green Green Pass Policy heterogeneous humoral humoral immune response immune Immunity implication individual maintain mRNA mRNA-1273 Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody observé Pass peptides Policy Protein Randomly Rapid test rationale RBD RBD-ACE2 reactivity reactogenicity Receptor-binding domain reduce reopening response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike selected sera serum serum sample significantly spike Spike protein synthetic peptide the receptor-binding domain titer vaccinated individual vaccination Vaccine virus spread [DOI] 10.3389/fimmu.2022.833085 PMC 바로가기 [Article Type] Article
Humoral Response to BNT162b2 Vaccine Against SARS-CoV-2 Variants Decays After Six MonthsSARS-CoV-2 변이체에 대한 BNT162b2 백신에 대한 체액 반응은 6개월 후 쇠퇴합니다.Article Published on 2022-05-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Against age age and gender Alpha Alter analyzed B.1 BNT162b2 BNT162b2 vaccine carried changes in Complete D614G decay decrease Delta determine Effectiveness evade evaluated Evidence FIVE Follow-up Gamma GraphPad humoral immune response immune escape mutation immune escape mutations immune response Immunity immunization immunogenicity individual men Month Neutralization assay Neutralizing Neutralizing activity Neutralizing antibodies neutralizing capacity Neutralizing titer Older participant plaque reduction neutralization Prospective Study protocols raised reduction response SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants serum serum sample serum samples severity shown Support titer titers Transmissibility vaccination Vaccine variant variants Viral viral variant Viral variants was measured [DOI] 10.3389/fimmu.2022.879036 PMC 바로가기 [Article Type] Article
Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 VaccineBNT162b2 mRNA COVID-19 백신 2~3회 투여 후 SARS-CoV-2 변이체에 대한 중화 항체 반응 평가Article Published on 2022-05-022022-09-11 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 95% CI Against age all age group all age groups assessment BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster vaccination cohort study conducted COVID-19 D614G variant delta variant dose group Immunity increase in induce Japanese Kobe lowest median age men Messenger RNA mRNA much higher Neutralizing antibodies neutralizing antibody Older age omicron Omicron variant other variant other variants outcome pandemic participant Participants physician Positive test positive test result recipient recipients response SARS-CoV-2 SARS-CoV-2 pandemic test results tested the SARS-CoV-2 the vaccine titer titers university vaccination Vaccine variant variants [DOI] 10.1001/jamanetworkopen.2022.10780 PMC 바로가기 [Article Type] Article
Exploratory assessment of serological tests to determine antibody titer against SARS-CoV-2: Appropriateness and limitsSARS-CoV-2에 대한 항체가를 결정하기 위한 혈청학적 검사의 탐색적 평가: 적절성 및 한계Multicenter Study Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] Analysis analyzed antibody Antibody titer Antibody titers appropriateness can be used Definition detect determine diagnostic diagnostic test diagnostic tests effective Effectiveness Elecsy Elecsys evaluated Health highlight IgA immunoassay Immunoglobulin immunoglobulins Infection International international standard International standards laboratory data limit limitation Luminex xMAP multicenter multiplex Multiplex assay multiplicity RBD resulting Roche S1 domain SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 test SARS-CoV-2 tests selected serological serological test Serological tests serum serum sample serum samples Siemen Spike protein Standard subject subjects the SARS-CoV-2 the WHO titer to define vaccination Variability WHO [DOI] 10.1002/jcla.24363 PMC 바로가기 [Article Type] Multicenter Study
Longer Intervals before Vaccination Increase Spike Antibody Titers in Individuals Previously Infected with SARS-CoV-2예방 접종 전 더 긴 간격은 SARS-CoV-2에 이전에 감염된 개인의 스파이크 항체 역가를 증가시킵니다Article Published on 2022-04-272022-09-12 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, [키워드] Abstract increase individual interval Neutralizing neutralizing antibody RBD RBD antibody SARS-CoV-2 spike titer Vaccine [DOI] 10.1128/spectrum.00238-22 PMC 바로가기 [Article Type] Article
Factors Associated with Change in SARS-CoV-2 Antibody Titers from Three to Six Months after the Administration of the BNT162b2 mRNA COVID-19 Vaccine among Healthcare Workers in Japan: A Prospective Study일본 의료 종사자의 BNT162b2 mRNA COVID-19 백신 투여 후 3개월에서 6개월 사이의 SARS-CoV-2 항체가 변화와 관련된 요인: 전향적 연구Article Published on 2022-04-152022-09-12 Journal: Internal medicine (Tokyo, Japan) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome administration age all subject all subjects analyzed Antibody titer BNT162b2 mRNA BNT162b2 vaccine booster change coronavirus COVID-19 COVID-19 vaccine declining decrease dose evaluated Factor healthcare healthcare worker Healthcare workers individual Japan Logistic regression analysis Month objective Older Prospective Result SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody titer titer vaccine administration worker [DOI] 10.2169/internalmedicine.8902-21 PMC 바로가기 [Article Type] Article