Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriaeArticle Published on 2021-03-082022-10-04 Journal: Nature Communications [Category] 변종, [키워드] analysed Antibiotic resistance Bacterial evolution Bacterial genomics bacterial toxins breadth caused clade Cluster core gene Corynebacterium diphtheriae country determine Diphtheria generate Genome genomic variation greater increase in isolate isolates Isolation medium Mutation Numerous Pathogens persistence Phylogeny Region resistance gene resistance genes Respiratory disease the disease toxin Vaccine variants Variation [DOI] 10.1038/s41467-021-21870-5 PMC 바로가기 [Article Type] Article
Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection폴리뉴클레오티드-아데노신 뉴클레오시다아제인 사포린은 SARS-CoV-2 감염에 효과적인 치료제가 될 수 있습니다Article Published on 2021-03-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] 진단, 치료제, [키워드] (rRNA abasic site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine agent Apoptosis Cell characteristic conserved coronavirus Coronavirus 2019 COVID-19 drug efficacious therapeutic enzymatic activity eukaryotic cells focus Genomic DNA high stability Hyperactivation Immunotherapy induce Infection inhibitor N-glycosidase Nucleosidase Pathways polymerase Protein protein synthesis residue respiratory ribosomal RNA RNA rRNA saporin. SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signal transduction Stress stress response therapeutic therapeutic agents toxin Treatment type I [DOI] 10.1177/2472555220970911 PMC 바로가기 [Article Type] Article
The Impact of SARS-CoV-2 Pandemic Lockdown on a Botulinum Toxin Outpatient Clinic in GermanyCommunication Published on 2021-01-292022-10-28 Journal: Toxins [Category] COVID-19, [키워드] Administered cervical dystonia changes in Characteristics clinic clinical compensated coronavirus correlated correlation COVID-19 pandemic Delay Delay in treatment disease entity doses Efficacy Germany Impact injection lockdown outcome Outpatient outpatient clinic pandemic partial lockdown Patient patients ranged recruited reported SARS-CoV-2 SARS-CoV-2 virus severity significantly Symptom symptom severity the mean the SARS-CoV-2 time toxin treated Treatment worsening worsening of symptoms [DOI] 10.3390/toxins13020101 PMC 바로가기 [Article Type] Communication
Endotoxemia and circulating bacteriome in severe COVID-19 patientsResearch Articles Published on 2020-12-072022-10-30 Journal: Intensive Care Medicine Experimental [Category] COVID-19, [키워드] 16S rRNA gene acute respiratory distress syndrome Adults amplification analyzed Bacterial Bacterial sepsis Blood blood sample Chulalongkorn circulating Circulating bacteriome circulation clinical feature contribute COVID-19 COVID-19 pneumonia patients Critically ill Culture determine disease DNA Endotoxemia endotoxin Enrollment Infection intensive care King mechanical ventilation Memorial Pathogenesis pathophysiology Patient patients positive Proteobacteria raise Result secondary bacterial infection Sepsis Sequencing serum severe COVID-19 patient severely ill patient the patient toxin with COVID-19 [DOI] 10.1186/s40635-020-00362-8 PMC 바로가기 [Article Type] Research Articles
Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico AnalysisResearch Article Published on 2020-11-192022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome Analysis association candidate vaccine caused cholera complex conducted coronavirus COVID-19 COVID-19 disease develop EAAAK linker epitope Epitopes feasible flexible globe GPGPG linkers Health HLA hydrogen bonds in vitro experiment in vivo Interaction molecular docking analysis multiepitope vaccine N-terminus positive protective immunity Safe SARS-CoV-2 sequence spike glycoprotein stability subunit suggested Support the Spike the vaccine toxin Vaccine was performed [DOI] 10.1155/2020/8893483 PMC 바로가기 [Article Type] Research Article
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid DevelopmentArticle Published on 2020-11-132022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] accompanied Activation acute respiratory syndrome adverse effect AEC Affect alveolar alveolar organoid angiotensin-converting enzyme 2 Cell childhood clade cofactor coronavirus demonstrated development developmental dPM2.5 EMT epithelial Evidence explain exposure to expression Extracellular fibrosis had no Human human pluripotent stem cells in vitro incidence infancy Inflammation investigated lack lung Lung function matter mechanism multicellular nicotinamide adenine dinucleotide Organoid Particulate phosphate platform pluripotent stem cell prenatal promoted protease Protein provided pulmonary disease receptor reduced Research SARS-CoV-2 serine 2 Signaling significantly STEM susceptibility target cells Toxicity toxin transition transmembrane treated Treatment unique upregulated upregulation virus [DOI] 10.3390/ijerph17228410 PMC 바로가기 [Article Type] Article
Can charcoal improve outcomes in COVID-19 infections?목탄이 COVID-19 감염의 결과를 개선할 수 있습니까?Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] 치료제, [키워드] Absorption activated activated charcoal Can cause charcoal COVID-19 COVID-19 infection Hypothesis IMPROVE Infection Inflammation Microbiome morbidity and mortality obese outcome renal function Stress toxin Treatment utility [DOI] 10.1016/j.mehy.2020.110176 PMC 바로가기 [Article Type] Article
Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screenCRISPR 매개 게놈 전체 화면을 사용하여 디프타마이드 생합성의 필수 조절자로서의 전사 인자 Miz1 식별Research Article Published on 2020-10-152022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Bacterial bacterial toxin bind binding site Biosynthesis Cell complex Consensus conserved CRISPR Diphthamide DPH1 Dph7 Drosophila eEF2 elegans embryonic lethal eukaryotes eukaryotic Evolution expression Factor Genes histidine human cells humans identification identify independent key factor mammals mice Modification modifications molecular target mRNA translation observation opens orthologue Pathogenesis pathway performed promoter Protein proximal question raise regulated Regulation remained required residue Seven Taking toxin toxins Transcription transcription factor transcriptional regulation unique unsaturated while yeast [DOI] 10.1371/journal.pgen.1009068 PMC 바로가기 [Article Type] Research Article
Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting ImplicationsArticle Published on 2020-08-132022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] 3D structure ACE2 acetylcholine receptors agonist Amino acid cell entry cell receptors cholinergic COVID-19 COVID-19 patients docking experiment domain dysregulation enzyme examined Extracellular form homolog homologous hospitalized COVID-19 patients Hypothesis identification implicated Inflammation Interaction modelled structure molecular neurotoxin Nicotine Nicotinic Cholinergic System observation pathophysiology performed Potential Prevalence PROTECT raise receptor SARS-CoV-2 sequence smoking spike subunit System targeting the SARS-CoV-2 the Spike therapeutic toxin virus while [DOI] 10.3390/ijms21165807 PMC 바로가기 [Article Type] Article
CytoResc – “CytoSorb” Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trialCytoResc – COVID-19 사이토카인 폭풍을 겪고 있는 중환자를 위한 "CytoSorb" 구조: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-06-262022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 24 hour 24 hours Acute kidney injury Acute respiratory failure Administered Analysis Antibiotics arterial arterial pressure Bacterial Berlin blinded Blinding block blocks Blood C-reactive protein C-reactive protein (CRP catecholamine cause center Chain Reaction Charité clinical Clinical course Clinical practice clinical trials clinically clinician comparator concentrations condition conducted contraindication COVID-19 COVID-19 patient COVID-19 patients Critical care Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine Cytokine storm Cytokines Cytosorb CytoSorb® data set death defined dissemination dose element elevated Endpoint extracorporeal cytokine elimination feasibility Filter Formal Germany Hemodynamics hospital discharge Hospitalization hospitalized patient hospitalized patients hyperinflammation Hyperinflammatory ICU-treatment ICUs IIb IL-6 IMPROVE Inc. Inclusion inclusion criteria indication intensive care unit intensive care units interleukin interleukin-6 intervention effect mean arterial pressure mechanical ventilation molecular weight Mortality multicenter New Norepinephrine number objective observational study occur Open-label other conditions outcome parallel group participant Patient patients PCR PCT performed phase pilot study polymerase chain polymerase chain reaction polystyrene positive pressure Prevent primary endpoint procalcitonin Proinflammatory cytokine proinflammatory cytokines protocol randomization Randomized Randomized controlled trial reason for receive recruited reducing Registered registry renal replacement therapy replacement therapy rescue Respiratory failure Safety Safety assessment Sample size SARS-CoV-2 secondary Secondary outcomes Shock shown Standard of care statistician status stratified Study design Study protocol Suspected therapy toxin Treatment Trial Trial registration USA vasoplegic shock Vasopressor vasopressors website [DOI] 10.1186/s13063-020-04501-0 PMC 바로가기 [Article Type] Letter