Super interactive promoters provide insight into cell type-specific regulatory networks in blood lineage cell types슈퍼 대화식 프로모터는 혈액 계통 세포 유형에서 세포 유형-특이 적 조절 네트워크에 대한 통찰력을 제공Research Article Published on 2022-01-312022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis ATAC-seq binding Blood blood cell Blood cells capture CD4 Cell cell type cell types chromatin compendium complex Critical disrupt driven by enhancer enhancers EPHB3 ETS1 explain Express expression level FIVE Follow-up functional Genetic variant GWAS GWAS variant GWAS variants help hematological hypothese identify implication include independent Interaction interactions interactivity Interpretation Lineage locus lymphocyte Lymphocyte count motifs norm overlap Phenotypes PIR Platelet Platelet count promoter promoters provide redundancy Region regions Regulatory regulatory network regulatory region resource strong interactions traits transcription factor transcriptional transcriptional regulation variant variants [DOI] 10.1371/journal.pgen.1009984 PMC 바로가기 [Article Type] Research Article
Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity유전자 연관성 데이터의 소음-증류 방향성 클러스터링Research Article Published on 2022-01-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting applied approach association biological pathway biological pathways BMI body mass body mass index can not Cluster Clustering complex Coronary heart disease correlated directional disease Effect elevated estimate generate Genetic genetic association Genetic variant genetic variants Genome-wide association studies group heart disease identify include Inflammation insight mechanism mechanisms Mendelian randomization analyses Mendelian randomization analysis mixture model obesity outliers provide question reduced risk robustness similarity statistical Support thought traits variant variants [DOI] 10.1371/journal.pgen.1009975 PMC 바로가기 [Article Type] Research Article
Difference in Pandemic-Related Experiences and Factors Associated with Sickness Absence among Nurses Working in COVID-19 and Non-COVID-19 DepartmentsArticle Published on 2022-01-192022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] checklist coping coping strategies Coping strategy CoV COVID-19 Croatia Department determine difference enrolled experience Factor group had more IMPROVE Infection inventory Non-COVID-19 Nurse Nurses occupational pandemic participated personality traits Post-traumatic stress disorder predict predictor variable Probability Prospective Study PTSD Questionnaires sickness absence situation split Stress Stressor subject subjects Symptom Symptoms traits university variable were used working [DOI] 10.3390/ijerph19031093 PMC 바로가기 [Article Type] Article
Mental imagery interventions to promote face covering use among UK university students and employees during the COVID-19 pandemic: study protocol for a randomized controlled trial.COVID-19 팬데믹 기간 동안 영국 대학생과 직원의 안면 가리개 사용을 촉진하기 위한 정신적 이미지 개입: 무작위 통제 시험을 위한 연구 프로토콜.Study Protocol Published on 2022-01-182022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 2020 COVID-19 pandemic age anticipated Arm assigned Attitudes baseline Behaviour behavioural cognitive Complete concerning conscientiousness contribute Control control condition core COVID-19 COVID-19 pandemic defined Effectiveness effort Evidence Factor Follow-up Frequency hand washing Health Imagery face coverings include individual Intention Intervention intervention effect Intervention effects library Medicine Mental narcissism Norms outcome participant personality traits post-intervention preventive measure preventive measures Primary outcome promote PROTECT protocol Randomized randomized controlled study Randomized controlled trial Randomly recruited Registered reported secondary Secondary outcomes Self-efficacy separate condition social distancing Spread Study protocol supplementary material time traits Trial Trial registration understanding university students Viral viral infection virus [DOI] 10.1186/s13063-021-05852-y PMC 바로가기 [Article Type] Study Protocol
Multiomics integration-based molecular characterizations of COVID-19COVID-19의 다중 유학 통합 기반 분자 특성Review Published on 2022-01-022022-09-01 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caused complex Consequences contributing to coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diagnostics disease pathogenesis Genetic variation Genomics Health help Host immune immunomics include inflammatory phenotype insight integration knowledge mechanism metabolomics molecular molecular characteristics multiomics multiomics integration offer outcome pandemic Pathogenesis pathogenesis of SARS-CoV-2 proteomics puzzle respiratory responses risk stratification SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity single-cell omics Systems biology target targets therapeutic traits transcriptomics unique Vaccine development virulence virus [DOI] 10.1093/bib/bbab485 PMC 바로가기 [Article Type] Review
Psychological factors affecting COVID-19 vaccine acceptance in IndonesiaResearch Published on 2021-12-202022-10-31 Journal: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery [Category] COVID-19, [키워드] Affect affecting cognitive collected combating COVID-19 COVID-19 pandemic COVID-19 test COVID-19 vaccine cross-sectional demographic data determinant Factor Frequency Government IBM identify Increasing Indonesia Indonesian Multivariate analysis Psychological Psychological factor psychological factors questionnaire refusal Result significantly smoking status SPSS 26.0 statistical analysis Statistical Package traits USA vaccination vaccination rate Vaccine Vaccine acceptance Vaccine hesitancy was used [DOI] 10.1186/s41983-021-00436-8 PMC 바로가기 [Article Type] Research
The Identikit of Patient at Risk for Severe COVID-19 and Death: The Dysregulation of Renin-Angiotensin System as the Common ThemeReview Published on 2021-12-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome adverse outcome Ang II Angiotensin 1-7 Arm Arterial hypertension binding cardiovascular disease cardiovascular morbidity caused characterized common conditions coronavirus coronavirus disease COVID-19 Diabetes Mellitus down-regulation dysregulation Evidence Health hospitalized patients hypertension increased risk Infection Lung injury Male sex metabolic condition metabolic syndrome obesity Older age opposite overweight pandemic pathophysiological Patient phenotype prevalent RAS receptor reducing renin-angiotensin system SARS-CoV-2 severe COVID-19 syndrome System traits type 2 diabete virus widespread [DOI] 10.3390/jcm10245883 PMC 바로가기 [Article Type] Review
Drinking and Social Media Use Among Workers During COVID-19 Pandemic Restrictions: Five-Wave Longitudinal StudyOriginal Paper Published on 2021-12-022022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] activities affected age alcohol app AUDIT-C conducted Control COVID-19 COVID-19 crisis COVID-19 pandemic Daily distress Drinking Effects examined excessive drinking Gender identification identity increase in Increased Involvement linear longitudinal media objective outcome pandemic participated pattern predict prediction Psychological distress remote work Result risk risk factor social media social media platform Sociodemographic factor survey Test traits trend worker [DOI] 10.2196/33125 PMC 바로가기 [Article Type] Original Paper
Controlling long-term SARS-CoV-2 infections can slow viral evolution and reduce the risk of treatment failure장기간 SARS-CoV-2 감염을 통제하면 바이러스 진화를 늦추고 치료 실패 위험을 줄일 수 있습니다Article Published on 2021-11-192022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] controlling convalescent plasma COVID-19 Critical event Evolution expansion favor herd immunity immune evasion Immunity Immunocompromised individual Infection infections Infectious diseases lead mutations natural selection occur patient population population level Prevent Probability reduce risk SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants subsequent targeting the patient traits Transmissibility Transmission treated Treatment variant variants variants of SARS-CoV-2 Viral viral evolution Viral load viral variant while [DOI] 10.1038/s41598-021-02148-8 PMC 바로가기 [Article Type] Article
Ace2 and Tmprss2 Expressions Are Regulated by Dhx32 and Influence the Gastrointestinal Symptoms Caused by SARS-CoV-2Article Published on 2021-11-162022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] ACE2 receptor Analysis approach associations BXD mice cellular entry chromosome 7 co-expression Control coronavirus disease covariation COVID-19 COVID-19 disease demonstrated expressed expression Gastrointestinal gastrointestinal tract Genetic genetics GI tissue implication indicated influence Interaction locus microbiota molecular molecular mechanism mRNA expression network analysis pathogenesis of COVID-19 pathway priming Protein quantified Quantitative SARS-CoV-2 SARS-COV-2 infection significantly Strains suggested systems genetics the spike protein the timing TMPRSS2 traits transcript Transcriptome Treatment [DOI] 10.3390/jpm11111212 PMC 바로가기 [Article Type] Article