tyrosine – Page 3 – Communicable Diseases Research

Activation of STAT3 signaling pathway in the kidney of COVID-19 patients

코로나19 환자의 신장에서 STAT3 신호전달 경로 활성화

Observational Study

Published on 2022-04-012022-09-11
Journal: Journal of Nephrology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술,

Do reduced numbers of plasmacytoid dendritic cells contribute to the aggressive clinical course of COVID-19 in chronic lymphocytic leukaemia?

감소된 수의 형질세포양 수지상 세포가 만성 림프구성 백혈병에서 COVID-19의 공격적인 임상 경과에 기여합니까?

Review

Published on 2022-04-012022-09-11
Journal: Scandinavian journal of immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘,

The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus Particles

SARS-CoV-2 스파이크 단백질의 "LLQY" 모티프는 S가 바이러스 입자에 통합되는 데 영향을 줍니다.

Article

Published on 2022-03-232022-09-11
Journal: Journal of Virology [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alter Amino acid amino acid residue amino acids antiviral drug antiviral drugs assembly biological significance Biosynthesis caused Cell culture cleavage cleavage site cleavage sites cleaved conformational conservation conserved Contact contribute coronavirus COVID-19 epidemic Critical demonstrated Effectiveness expressed glycoprotein hydrogen Hydrogen bond hydrogen bonds incorporation Infection intrachain junction key amino acid key amino acids less Lineage LLQY domain membrane fusion motif mutated Mutation Neutralizing antibodies Particle Prevent processing producer cell protease Protein protein synthesis protein synthesis and cleavage Pseudotyped virus pseudovirus pseudoviruses reduce residue S protein S1/S2 SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability subcellular localization synthesis the S protein the SARS-CoV-2 Transmission tyrosine Vaccines viral entry viral infection virus virus assembly Virus-like particle virus-like particles
[DOI] 10.1128/jvi.01897-21 PMC 바로가기 [Article Type] Article

Improved Binding Affinity of Omicron’s Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence

인간 안지오텐신 전환 효소 2 수용체에 대한 오미크론 스파이크 단백질의 향상된 결합 친화도는 독성 증가의 핵심입니다

Article

Published on 2022-03-212022-09-11
Journal: International Journal of Molecular Sciences [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Amino acid amino acid residue amino acids angiotensin Antiviral agents binding binding free energies binding free energy characterized complex contribute coronavirus country D38 domain electrostatic interaction enzyme exhibited free energy genomic region hACE2 hACE2 receptor Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human angiotensin-converting enzyme 2 (hACE2) hydrogen hydrogen bonding Improved Increased information Interaction investigated mode molecular molecular dynamics Molecular dynamics simulation Molecular mechanics molecular mechanics-generalized Born surface area (MM-GBSA) mutated Mutation omicron Omicron variant Other pi-stacking RBD receptor Receptor-binding domain Receptor-binding domain (RBD) receptor-binding motif Receptor-binding motif (RBM) residue resulting salt bridges SARS-CoV-2 SARS-CoV-2 RBD Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spike Spike protein surface area the RBD the spike protein Transmissibility tyrosine variant variant of SARS-CoV-2 virus wild type
[DOI] 10.3390/ijms23063409 PMC 바로가기 [Article Type] Article

Characterization of a SARS-CoV-2 spike protein reference material

SARS-COV-2 스파이크 단백질 기준 물질의 특성

Paper in Forefront

Published on 2022-03-092022-09-10
Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), Fulltext, MERS, SARS, 치료기술,

[키워드] absorbance Amino acid Analysis assist calculated Canada changes in characterization Combination Community Concentration Council COVID-19 COVID-19 pandemic density development diagnostic diagnostic testing Dilution fraction glycoprotein glycosylated homogeneity hydrolysis Isotope dilution lack leads Liquid chromatography mass spectrometry material molar concentration molecular weight National Research Council Canada Protein reference reference material Reference materials reported Research SARS-CoV-2 SARS-CoV-2 spike protein scattering Spike protein stability Standardization supplementary material Tandem mass spectrometry test results the spike protein trimeric Tryptophan tyrosine value were assessed
[DOI] 10.1007/s00216-022-04000-y PMC 바로가기 [Article Type] Paper in Forefront

Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients

면역 저하 환자에서 mRNA SARS-CoV-2 백신 접종에 대한 반응을 평가하는 초기 임상 시험의 통찰력

Review

Published on 2022-03-042022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] adaptive administration agonist animal model Anti-CD19 anti-CD20 anti-CD38 Assessing BNT162b2 CD4 clinical clinical trial component COVID-19 Critical CTLA4 deficiency dose effective Genetic healthy humans immune systems Immunocompromised Immunocompromised patient immunodeficiency Immunosuppressed Immunosuppressive medication inborn errors of immunity increased risk insight jak inhibitors knowledge mRNA mRNA vaccination mRNA vaccine mRNA-1273 mRNA1273 Patient predictor PROTECT response SARS-CoV-2 SARS-CoV-2 vaccination severe disease T-cell the vaccine therapeutic Therapies transplantation Treatment Trial tyrosine vaccination Vaccine
[DOI] 10.3389/fimmu.2022.827242 PMC 바로가기 [Article Type] Review

sFlt-1/PlGF ratio in hypertensive disorders of pregnancy in patients affected by COVID-19

COVID-19의 영향을 받는 환자의 임신 고혈압 장애에서 sFlt-1/PlGF 비율

Multicenter Study

Published on 2022-03-012022-09-11
Journal: Pregnancy hypertension [Category] 바이오마커,

[키워드] adjusted affected Analysis case analysis Comorbidities Comorbidity Complete Concentration control group controls COVID COVID-19 COVID-19 patient COVID-19 patients damage demographic differential diagnosis disorder endothelial Evolution Factor finding Follow-up greater hypertensive hypertensive disorders of pregnancy Infection kinase normotensive obesity outcome Patient patients preeclampsia Pregnancy Pregnancy comorbidities pregnant patient pregnant patients Prevalence recruited recruitment SARS-COV-2 infection SARS-CoV2 infection severity sFlt-1/PlGF ratio. syndrome the disease tyrosine Univariate analysis women
[DOI] 10.1016/j.preghy.2021.12.001 PMC 바로가기 [Article Type] Multicenter Study

Isolation and Genomic Characterization of SARS-CoV-2 Omicron Variant Obtained from Human Clinical Specimens

인간 임상 표본에서 얻은 SARS-CoV-2 오미크론 변이체의 분리 및 게놈 특성화

Article

Published on 2022-02-242022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] absence Analysis approach B.1.1.529 Cell Cell culture cell suspension changes in characterization clinical collected Contact COVID-19 cases Cytopathic effect demonstrated E gene failure followed by furin furin cleavage site Genome genome analysis hamster hamsters high viral load Host Human in vitro in vivo India infected cell infected cells initial inoculated International Isolation lung Mumbai Mutation nasal nasal turbinate Next-generation sequencing nucleotide omicron Omicron variant passage passages pathogenicity positive Replication SARS-CoV-2 sequence sequenced specimen specimens spike gene subsequent Syrian hamster tyrosine variant Vero CCL-81 Vero CCL-81 cell Vero CCL-81 cells Viral load virus virus isolate virus isolation
[DOI] 10.3390/v14030461 PMC 바로가기 [Article Type] Article

The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19

INVENT COVID 시험: COVID-19에 의해 유발된 급성 호흡곤란 증후군이 있는 피험자를 대상으로 정맥 이마티닙 메실레이트(Impentri®)의 효능과 안전성을 조사하는 무작위 대조 시험을 위한 구조화된 프로토콜

Study Protocol

Published on 2022-02-162022-09-10
Journal: Trials [Category] COVID19(2023년), MERS, SARS, 임상,

[키워드] 1:1 28-day mortality acute respiratory distress acute respiratory distress syndrome Admission ARDS Berlin criteria bis in die Chain Reaction changes in characterized clinical trial coronavirus disease Coronavirus disease 2019 COVID COVID-19 death decrease demonstrated discharge disease severity double-blind edema Efficacy and safety endothelial Endothelial dysfunction Estimated Extravascular lung water hypoxemic Hypoxemic respiratory failure ICU Imatinib imatinib mesylate immune response include increase in index Inflammation inflammatory conditions inhibitor intensive care intensive care unit intravenous Invasive mechanical ventilation IV infusion Kinase inhibitor life-threatening lung Lungs mechanical ventilation mechanically ventilated mesylate moderate-severe Mortality multicenter Older outcome Oxygenation pandemic parallel-group parameter parameters participant pharmacokinetics Placebo placebo-controlled polymerase chain polymerase chain reaction positive Prevent protocol Pulmonary edema randomization Randomized Randomized controlled trial recruitment reduce reduction in reflected respiratory distress Respiratory failure SARS-CoV2 secondary study period subject syndrome therapy Tolerability Trial registration tyrosine tyrosine kinase inhibitor Vascular vascular permeability Ventilation ventilator-free day Ventilator-free days water widespread
[DOI] 10.1186/s13063-022-06055-9 PMC 바로가기 [Article Type] Study Protocol

Efficacy of a third BNT162b2 mRNA COVID-19 vaccine dose in patients with CLL who failed standard 2-dose vaccination

표준 2회 접종에 실패한 CLL 환자에서 3차 BNT162b2 mRNA COVID-19 백신 접종의 효능

Clinical Trial

Published on 2022-02-032022-09-12
Journal: Blood [Category] COVID19(2023년), MERS, SARS, 임상, 진단,