Identifying Louisiana communities at the crossroads of environmental and social vulnerability, COVID-19, and asthmaResearch Article Published on 2022-02-232022-10-28 Journal: PLoS ONE [Category] Coronavirus, COVID19(2023년), MERS, SARS, [키워드] affected affecting ambient analyzed Asthma average benefit Community conditions correlated correlation COVID-19 COVID-19 incidence COVID-19 pandemic cumulative exacerbated Factor Health help Hospitalization identifying index indirect effect Justice less matter pandemic Particulate Prevalence Research Risk factors social determinant underlie vulnerability [DOI] 10.1371/journal.pone.0264336 PMC 바로가기 [Article Type] Research Article
Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance돌연변이 저항성이 높은 SARS-CoV-2에 대한 초강력 중화항체Research Article Published on 2022-02-152022-09-10 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibodies antibody Antibody avidity Betacoronavirus binding blocking cell entry cell entry complex COVID-19 crystal structure Drug screens drug therapy eliminating expressing F486 functional hotspot IgG mechanism mutant mutant viruses Mutation NAb NAbs neutralization Neutralizing antibodies neutralizing antibody Pharmacology potency profile RBD RBDs Receptor binding domain residue SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody screened Spike protein susceptible the RBD the spike protein underlie unique variants variants of concern Viral viral escape Virus neutralization yeast [DOI] 10.1172/JCI154987 PMC 바로가기 [Article Type] Research Article
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicityArticle Published on 2022-02-082022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] alcohol antioxidant Apoptosis bone marrow failure Caenorhabditis elegan Cancer metabolism cause cellular cellular damage Chemical genetics coding contributing to crosslinking cytotoxicity DNA DNA damage DNA repair endogenous enzyme formaldehyde functional GSH human cell Mechanisms of disease metabolic pathways metabolite Mutation oxidative stress Patient prevented PROTECT question raising Redox imbalance reduced resulting syndrome Therapeutic benefit thiol group thought Toxicity Trigger underlie yielding [DOI] 10.1038/s41467-022-28242-7 PMC 바로가기 [Article Type] Article
Mechanisms that may underlie a causal association between SARS-COV-2 infection and preeclampsiaSARS-COV-2 감염과 자간전증 사이의 인과 관계의 기초가 될 수 있는 기전Comment Published on 2022-02-012022-09-11 Journal: American journal of obstetrics and gynecology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] association Infection underlie [DOI] 10.1016/j.ajog.2021.09.007 PMC 바로가기 [Article Type] Comment
Prevalence of symptoms in 1512 COVID-19 patients: have dizziness and vertigo been underestimated thus far?Im - Original Published on 2022-01-302022-10-30 Journal: Internal and Emergency Medicine [Category] COVID-19, SARS, [키워드] acute infection affected analyzed balance disorder Balance Disorders Characteristics concerning COVID-19 Diagnosis discharged disorders Dizziness exacerbated female females individual investigated large sample male males mandatory median age Mild-to-moderate MOST Nasopharyngeal swab pathophysiological mechanism Patient patients Physicians Presyncope Prevalence quarantine question reported risk SARS-CoV-2 SARS-COV-2 infection significantly more specific symptom Stress subject Symptom symptoms of COVID-19 underlie vertigo [DOI] 10.1007/s11739-022-02930-0 PMC 바로가기 [Article Type] Im - Original
Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome치명적인 COVID-19 폐렴과 다기관 염증 증후군이 있는 어린이의 유전성 IFNAR1 결핍Case Reports Published on 2022-01-282022-09-10 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] autoantibodies autoantibody autosomal recessive candidate gene cause causes Child children contribute COVID-19 COVID-19 pneumonia Critical critical pneumonia Cytokines detect died dysregulation Exome Genetic variant homozygous IFNAR1 IFNAR1 deficiency IFNs Immunity Inborn error inborn errors of immunity (IEI) Inflammatory interferons investigated loss-of-function MIS-C multisystem inflammatory syndrome in children (MIS-C) objective patients Plasma level Plasma levels Pneumonia primary immunodeficiency (PID) raise Result SARS-COV-2 infection Sequencing specific antibodies specific antibody supplementary material syndrome Type I IFN type I IFNs type I interferon type I interferons underlie variant virus was performed [DOI] 10.1007/s10875-022-01215-7 PMC 바로가기 [Article Type] Case Reports
Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytesArticle Published on 2022-01-282022-10-04 Journal: Communications Biology [Category] 바이오마커, [키워드] Analysis analyzed bacterial endotoxin Characteristics Chronic diseases chronic inflammation condition contribute COVID-19 driving Epigenetic epigenomic epigenomics evaluate expression Gene Expression Genes High dose High-dose immune induce Inflammation interferon response low dose low-dose low-grade inflammation LPS marrow-derived macrophage memory Modification monocyte murine occur Pathogenesis pathogenic pathway Pathways PBS proliferative Regulation responses Sepsis Signaling target the cell therapeutic TLR4 transcriptomic underlie upregulate while [DOI] 10.1038/s42003-022-03035-2 PMC 바로가기 [Article Type] Article
Belonging to Socially Excluded Groups as a Predictor of Vaccine Hesitancy and RejectionPublic Health Published on 2022-01-202022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] adhere administration approach association Belonging Conspiracy theories covert COVID-19 COVID-19 pandemic COVID-19 vaccine Effectiveness examined excluded exclusion criteria group Hesitancy hidden identify individual individual level large sample less optimism partially excluded social groups predicted question questionnaire refusal rejection Research second suggested the vaccine underlie vaccination Vaccine Vaccine hesitancy vaccine rejection [DOI] 10.3389/fpubh.2021.823795 PMC 바로가기 [Article Type] Public Health
Corticosteroid treatment in COVID-19 modulates host inflammatory responses and transcriptional signatures of immune dysregulationCOVID-19의 코르티코스테로이드 치료는 숙주의 염증 반응과 면역 조절 장애의 전사 신호를 조절합니다Article Published on 2021-12-012022-09-11 Journal: Journal of leukocyte biology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute SARS-CoV-2 infection adaptive Adaptive immunity age Analysis antibodies apoptotic causative agent cell death characterized clinical care Comorbidity condition conducted coronavirus coronavirus disease coronavirus disease-2019 Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids COVID-19 COVID-19 patient COVID-19 patients COVID19 cross-sectional diabetes Diabetic disease severity driver expression Hospitalized host inflammatory response host response hypertension immune immune dysregulation Immunity increased expression indicate Inflammation Inflammatory investigated longitudinal analysis male Male sex mechanism mediators Mild modulate molecular obesity Pathogenesis Patient pro-apoptotic receiving reduced respiratory Respiratory disease responses risk factor robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severe disease severity Standard of care steroid Steroids systemic inflammation These data transcriptional transcriptional profile transcriptional profiles transcriptional response transcriptional responses transcriptional. Treatment underlie use of corticosteroid while [DOI] 10.1002/JLB.4COVA0121-084RR PMC 바로가기 [Article Type] Article
Randomized trial drug controlled compendious transcriptome analysis supporting broad and phase specific therapeutic potential of multiple candidates in COVID-19Randomized Controlled Trial Published on 2021-12-012022-10-04 Journal: Cytokine [Category] 바이오마커, 신약개발, 임상, 치료제, [키워드] Admissions Affect Analysis Anticytokines antiinflammatory assumption benefit Biomarker candidate cellular clinical study coronavirus disease COVID-19 cytokine cytokine release Deceased Dexamethasone discharged disease Drug discovery drugs Effect effective Effectiveness examined expected hydroxychloroquine/chloroquine hyperinflammation ICU implicated inhibiting intensive care Intervention non-ICU opposite outcomes oxygen supplementation patients Predictive Proinflammatory cytokine proinflammatory cytokines randomized clinical trial RCT Regulation severity Stage supported the disease therapeutic effects therapeutic potential Therapeutics therapy Tofacitinib Transcriptome transcriptomic transcriptomic data Treatment Trial underlie Ventilation [DOI] 10.1016/j.cyto.2021.155719 PMC 바로가기 [Article Type] Randomized Controlled Trial