Determination of Ligand Binding Modes in Hydrated Viral Ion Channels to Foster Drug Design and Repositioning약물 디자인 및 재배치 촉진을 위한 수화된 바이러스 이온 채널의 리간드 결합 모드 결정Article Published on 2021-07-272022-09-10 Journal: Journal of Chemical Information and Modeling [Category] MERS, SARS, 신약개발, 치료제, [키워드] amantadine antiviral drug atomic resolution binding bridging interaction build candidate capture channel complex complex structure complexes COVID-19 pandemic derivative Determination determined by Diversity drug drug candidate drug design Drug discovery envelope protein experiment foster help hydrocarbon hydrophobic IMPROVE Influenza influenza A investigated Ion ion channel ion channels Ligand mechanism of action mode Numerous positioned protocol Region reliability repositioning resulting SARS-CoV-2 scratch Structure structures the SARS-CoV-2 transmembrane Undetermined water water molecules waters while [DOI] 10.1021/acs.jcim.1c00488 PMC 바로가기 [Article Type] Article
ddPCR increases detection of SARS-CoV-2 RNA in patients with low viral loadsDDPCR은 바이러스 부하가 낮은 환자에서 SARS-COV-2 RNA의 검출을 증가시킵니다.Original Article Published on 2021-07-122022-09-10 Journal: Archives of Virology [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] airway Cell coding concerning COVID-19 diagnose Diagnosis digital PCR droplet expressed framework French Helicase hospital in vitro increase Infection investigated Molecular diagnosis MONITOR N gene N or E Nasopharyngeal swab nasopharyngeal swabs pandemic Paris Patient PCR positive proportion qPCR RdRP Region replicative RNA RNA sequence RNA sequences RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA scored sensitivity significantly subgenomic RNA supplementary material targets Undetermined upper airway Viral load [DOI] 10.1007/s00705-021-05149-0 PMC 바로가기 [Article Type] Original Article
Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance심혈관 자기 공명으로 평가한 회복된 트로포닌 양성 COVID-19 환자의 심근 손상 패턴Article Published on 2021-05-142022-09-11 Journal: European heart journal [Category] Fulltext, SARS, 치료기술, [키워드] adenosine cardiovascular Cardiovascular Magnetic Resonance change clinically Control convalescence convalescent coronary disease COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients de novo diffuse discharged disease Ejection fraction Evidence evidence of fibrosis functional gadolinium had no heart disease hospital Hospital admission hospitalized COVID-19 patients indicated Infarction Inflammation Injury Ischaemic heart disease left less LV dysfunction male median Myocardial Myocardial infarction myocardial injury Myocardial oedema myocarditis Myocardium no evidence of oedema past history pathology Patient patients pattern proportion quarter Recovered COVID-19 patients SARS-CoV-2 scar Severe COVID-19 Infection silent Stress troponin underlying aetiology Undetermined ventilatory ventilatory support ventricular [DOI] 10.1093/eurheartj/ehab075 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms안구 증상이 없는 환자의 결막 분비물에서 SARS-CoV-2 검출Article Published on 2021-04-012022-09-11 Journal: Infection [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Appropriate Asymptomatic Chain Reaction collected Conjunctiva conjunctival Conjunctival secretion Conjunctival secretions Conjunctival swab conjunctival swabs coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Ct values Culture detection duration of illness evaluate infection control laboratory-confirmed measure median nosocomial Nosocomial transmission ocular ocular symptoms Patient polymerase chain reaction positive Prevent ranged reverse transcription Reverse transcription-polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 RNA secretion severe acute respiratory syndrome Coronavirus shedding Swab Symptom Symptoms transmission of SARS-CoV-2 Undetermined viral culture was obtained [DOI] 10.1007/s15010-020-01524-2 PMC 바로가기 [Article Type] Article
A Faculty Development Workshop for Planning and Implementing Interactive Virtual Case-Based TeachingOriginal Publication Published on 2021-03-172022-10-30 Journal: MedEdPORTAL : the Journal of Teaching and Learning [Category] Coronavirus, SARS, [키워드] Cased-Based Learning Clinician Educators COVID-19 pandemic demonstrated development distance effective effort engage evaluate facilitate facilitator faculty Faculty Development group Health Health profession Implementing increasingly Online/Distance Learning organized participant participated physical distance Planning platform provided reported required Result subject survey Teaching Undetermined Virtual Learning workshop [DOI] 10.15766/mep_2374-8265.11126 PMC 바로가기 [Article Type] Original Publication
Renal Morphology in Coronavirus Disease: A Literature Review코로나바이러스 질병의 신장 형태: 문헌 검토Review Published on 2021-03-112022-09-10 Journal: Medicina [Category] SARS, 유전자 메커니즘, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response addition cascades Case report case reports Case series case sery caused change Collapsing conducted coronavirus coronavirus disease COVID-19 cytokine damage described Diseases focal segmental glomerulosclerosis genetic component glomerular glomerular diseases glomerulosclerosis help highlight histological Infection innate and adaptive immune response kidney Kidney failure kidney tissue kidneys leads lesion lesions literature mechanism morbidity Morphological morphological finding morphological findings Pathogenesis Patient patients procoagulant renal biopsy renal morphology respiratory review SARS-CoV-2 severe acute respiratory syndrome Coronavirus triggering Undetermined variety Vascular vascular diseases virus [DOI] 10.3390/medicina57030258 PMC 바로가기 [Article Type] Review
High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms신경계 증상이 있는 코로나19 환자에서 뇌척수액 자가항체의 높은 빈도Article Published on 2021-03-012022-09-12 Journal: Brain, behavior, and immunity [Category] MERS, 진단, [키워드] absence analyzed autoantibodies autoantibody autoantigen Autoimmunity binding Brain brain tissue cerebrospinal fluid Clinical symptoms COVID-19 COVID-19 patient Critically ill CSF delirium disease Encephalitis Endothelium Epitopes explain Frequency ganglia hyperexcitability immunofluorescence Immunotherapy intensive care patient monoclonal murine neurological Neurological symptom NEUROLOGY neuronal NMDA olfactory Patient potential molecular presenting Protein receptor SARS-CoV-2 SARS-CoV-2 antibodies Seizures selected serum surface proteins Undetermined vessel Viral-triggered. virus-neutralizing antibody [DOI] 10.1016/j.bbi.2020.12.022 PMC 바로가기 [Article Type] Article
Circulating mitochondrial DNA is an early indicator of severe illness and mortality from COVID-19순환하는 미토콘드리아 DNA는 COVID-19로 인한 중증 질병 및 사망률의 초기 지표입니다Clinical Medicine Published on 2021-02-222022-09-10 Journal: JCI Insight [Category] MERS, 바이오마커, 진단, [키워드] Admission age assessment Care circulating circulating cell clinical clinically collected Comorbidities complement COVID-19 COVID-19 therapy damaged died DNA elevated funding hospital ICU ICU admission immunology independent independent of independent risk factor Inflammation Inflammatory Inflammatory marker intensive care unit intrinsically intubation marker measure Mitochondria mitochondrial mitochondrial DNA Mortality multivariate multivariate regression analysis NIH nucleic acid nucleic acids outcome outcomes Patient plasma sample plasma samples predict Primary outcome Program quantitation receiver operating characteristic released renal replacement therapy replacement therapy reported required Result risk Risk factors Science Secondary outcomes Sex solid organs subject target therapy Undetermined university Vasopressor Washington were used with COVID-19 [DOI] 10.1172/jci.insight.143299 PMC 바로가기 [Article Type] Clinical Medicine
Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosisResearch Article Published on 2021-01-112022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] activated antiviral drugs Apoptosis bronchitis cause Cell cell death component contagious disease Coronavirus infection correlated dominant negative DUSP6 ERK ERK1/2 expression Extracellular facilitate facilitated form IBV IBV infection impair Infectious Bronchitis Virus inhibitor Interaction investigated mutant negative regulation Pathogenesis pathway phosphatase Phosphorylation promoted reduced regulate Regulation Replication restrict shown Signaling signaling pathway siRNA suppressed target therapeutic These data Undetermined viral infection viral infections Viral load viral replication virus virus replication [DOI] 10.1186/s13567-020-00866-x PMC 바로가기 [Article Type] Research Article
Immunogenicity of Multiple Doses of pDNA Vaccines against SARS-CoV-2Article Published on 2021-01-062022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] Activation acute respiratory syndrome antibody Antibody Response binding candidate cellular immune responses comparable coronavirus coronavirus disease COVID-19 COVID-19 vaccine death dose doses effective elicit full-length S globular head highest immune responses Immunity immunogenicity induce interferon Limited long-lasting magnitude marker mice Multiple natural infection Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses Pandemics pDNA Plasmid preclinical data Reinfection required robust S-specific antibody SARS-CoV-2 SARS-CoV-2 vaccine Serum level Support translational Undetermined Vaccine viral spike virus Wuhan, China [DOI] 10.3390/ph14010039 PMC 바로가기 [Article Type] Article