Increased Interleukin 18-Dependent Immune Responses Are Associated With Myopericarditis After COVID-19 mRNA Vaccination증가된 인터루킨 18 의존성 면역 반응은 COVID-19 mRNA 백신 접종 후 심근염과 관련이 있습니다Immunology Published on 2022-02-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] abnormality activated Activation administration Cardiac complications caused CD68 Cell characterized chest pain circulating Control controls COVID-19 COVID-19 mRNA Vaccination COVID-19 mRNA vaccine COVID-19 vaccination cytokine Cytokines disease onset dysfunction elevated expressed first dose Flow cytometry analysis healthy individual hearts IL-18 IL-27 Immune profile immune response incidence Increased individuals infiltration interleukin interleukin 18 mechanism mice Mild monocyte mRNA mRNA-1273 COVID-19 vaccine multiplex Myopericarditis NK cell NK cells NLRP3 inflammasome occur Patient phenotype progression response T cell Th1-type immune response the patient troponin I upstream vaccinated individual vaccination were used with COVID-19 [DOI] 10.3389/fimmu.2022.851620 PMC 바로가기 [Article Type] Immunology
Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosisResearch Published on 2022-02-092022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] acute respiratory syndrome affected aggregation Analysis binding Cell circulating platelet Clinical outcome Coagulopathy coding coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression Critical eight energy metabolism feature healthy donors Hemostasis immune response immunothrombosis implication increased mortality Interaction involved mechanism molecular mechanism multiple organ failure Pathways patients with COVID-19 performed Platelet platelet activation Platelets promoted Protein provided regulate Result reveal risk RNA RNA Polymerase II RNA sequencing SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severity significantly subunit supplementary material therapeutic strategy thrombosis thrombotic complication thrombus formation transcription factor transcriptional Transcriptome upstream with COVID-19 [DOI] 10.1186/s13578-022-00750-5 PMC 바로가기 [Article Type] Research
Analysis of the COVID-19 pandemic: lessons towards a more effective response to public health emergenciesResearch Published on 2022-02-042022-11-01 Journal: Globalization and Health [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Analysis approach approaches build Care concern conducted country COVID-19 COVID-19 pandemic curative death deaths determine develop effective effective response Emergency Epidemics equity explain expression forms Governance Health health systems heterogeneity IMPROVE information International National non-communicable diseases older population organized pandemic Pandemics Public public health public health emergency Quantitative data recognize Region Result Spearman’s correlation thematic analysis upstream [DOI] 10.1186/s12992-022-00805-9 PMC 바로가기 [Article Type] Research
Building knowledge of university campus population dynamics to enhance near-to-source sewage surveillance for SARS-CoV-2 detectionSARS-CoV-2 감지를 위해 근원지에서 가까운 하수 감시를 강화하기 위해 대학 캠퍼스 인구 역학에 대한 지식 구축Article Published on 2022-02-012022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activity addressed arising Biomarkers building collected complementary Concentration concentrations confidence COVID-19 COVID-19 pandemic demonstrated England ENhance Epidemiology estimate Focusing help identify information knowledge management Near-to-source Normalisation outbreak pathogen transmission Population Population size populations provide provided Public health intervention Public health interventions SARS-CoV-2 SARS-CoV-2 detection shown significant difference significant differences subject Surveillance the SARS-CoV-2 triggering upstream Variability Variation wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2021.150406 PMC 바로가기 [Article Type] Article
The economic and public health impact of intellectual property licensing of medicines for low-income and middle-income countries: a modelling study저소득 및 중간 소득 국가를 위한 의약품의 지적 재산권 라이선스가 경제 및 공중 보건에 미치는 영향: 모델링 연구Article Published on 2022-02-012022-09-11 Journal: The Lancet. Public Health [Category] COVID19(2023년), SARS, 치료제, [키워드] absence arising assumption benefit chain country COVID-19 pandemic cumulative cumulative effect daclatasvir death dolutegravir downstream Effect Effects estimate faster HCV Health hepatitis C hepatitis C virus HIV leads Medicine Medicines option outcome outcomes Patent Patent Pool patients treated pool predicted Primary outcome Primary outcomes public health Quantitative reduction Research robust suggested Supply chain These data upstream Volume [DOI] 10.1016/S2468-2667(21)00202-4 PMC 바로가기 [Article Type] Article
A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanismResearch article Published on 2022-01-262022-10-05 Journal: Patterns [Category] 신약개발, [키워드] Alzheimer disease approach candidate Candidates clinical study Compound computational modeling Data integration demonstrated drug Drug repurposing Genes HDAC6 identify in vitro screening Knowledge graph mechanism pathophysiological mechanism pathophysiology Phosphorylation resulting screened target tau phosphorylation upstream variety [DOI] 10.1016/j.patter.2021.100433 [Article Type] Research article
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granulesArticle Published on 2022-01-242022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] activating affected Antiviral antiviral host response antiviral immunity attenuate cofactor complex coronavirus correlation COVID-19 Defense dsRNA ectopic expression expression G3BP1 HEK293T cell highly pathogenic IFN immune evasion Infection Infectious diseases inhibiting innate antiviral immunity Innate immunity IRF3 less mechanism N protein nsp5 nuclear pathogenic pathway Phosphorylation Prevent regulate RIG-I RIG-I signaling pathway SARS-CoV-2 Sendai virus Spread Stress stress granule suppressed target TBK1 the N protein upstream vesicular stomatitis virus [DOI] 10.1038/s41392-022-00878-3 PMC 바로가기 [Article Type] Article
Meta-Analysis of APP Expression Modulated by SARS-CoV-2 Infection via the ACE2 ReceptorArticle Published on 2022-01-212022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome affected Alzheimer’s disease Alzheimer’s disease amyloid-beta precursor protein angiotensin-converting enzyme-2 app binding canonical caused characterized cleavage conducted core coronavirus Coronavirus-2019 COVID-19 downregulated exacerbating expression Infection Inflammation Ingenuity Pathway Analysis investigated involved IPA less Meta-analysis modulation Neuroinflammation P -value pathway plaque precursor progression Protein receptor resulting SARS-CoV-2 severe acute respiratory syndrome-coronavirus-2 signaling pathway upregulated upregulation upstream virus Z-score [DOI] 10.3390/ijms23031182 PMC 바로가기 [Article Type] Article
Pulmonary Mesenchymal Stem Cells in Mild Cases of COVID-19 Are Dedicated to Proliferation; In Severe Cases, They Control Inflammation, Make Cell Dispersion, and Tissue RegenerationImmunology Published on 2022-01-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] “cytokine storm” affected Alter Analysis biological function bronchoalveolar lavage sample CD40 Cell cell proliferation Cell therapy cell types chemotaxis clinical conditions Control COVID-19 COVID-19 patient Cytokine storm cytoplasmic Data analysis dispersion FHL2 Genes IFNGR1 IFNGR2 immune individual individuals induce inhibitor involved lung marker MDA5 mesenchymal stem cell Mild mild case mild COVID-19 patients MSC MSCs Necrosis NF-κB NFKBIA not express OPTN overexpression paracrine Patient performed PKR PPP2CB promote inflammation pulmonary receptors regeneration RNA secretion sequence Severe case severe COVID-19 single cell RNA sequencing single-cell RNA-seq STEM stem cell Target genes therapeutic therapeutic potential therapy for COVID-19 these cell tissue tlr-3 TLRs TNFR1 TNFR2 Transcription transcriptionally treat triggered upregulated upregulated gene upstream virus virus load [DOI] 10.3389/fimmu.2021.780900 PMC 바로가기 [Article Type] Immunology
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responsesMEK1/2 억제제 ATR-002는 SARS-CoV-2 전파를 효율적으로 차단하고 전염증성 사이토카인/케모카인 반응을 완화합니다Original Article Published on 2022-01-102022-09-10 Journal: Cellular and Molecular Life Sciences [Category] 치료제, [키워드] accelerated activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alleviate anti-influenza drug Anti-SARS-CoV-2 Activity antiviral drug ATR-002 block cascade caused Cell Cell culture cell line cell lines clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression cultures Cytokines death Disease progression Drug evaluation early infection epithelial epithelial cell evaluated expression fibrosarcoma high-risk patient High-risk patients hyperinflammation impair Infection inhibitor kinase kinases knockdown limit medication MEK1/2-inhibitor mitogen mitogen-activated protein kinase Novel coronavirus observé pandemic pandemic spread pathway powerful tool Prevent pro-inflammatory pro-inflammatory cytokines Protein Raf/MEK/ERK respiratory response Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 propagation selective severe acute respiratory syndrome Coronavirus Signaling specific inhibitor Spread supplementary material Symptom target therapeutic intervention Treatment upstream vaccination virus replication while [DOI] 10.1007/s00018-021-04085-1 PMC 바로가기 [Article Type] Original Article