Translation-Associated Mutational U-Pressure in the First ORF of SARS-CoV-2 and Other CoronavirusesMicrobiology Published on 2020-09-222022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] amino acid substitutions Analysis caused coronavirus Coronavirus infections Coronaviruses COVID-19 COVID-19 pandemic cytosine cytosine deamination Deamination degenerate Efficiency genomic RNA globe implication investigated knowledge MERS mutational pressure Non-synonymous nucleotide nucleotide mutation nucleotide mutations observation ORF ORF1a ORF1ab ORF1b Other question Replication residue RNA SARS SARS-CoV-2 sequence significantly higher synonymous translated translation treating COVID-19 uracil Vaccine Viral RNA virus Wuhan strain [DOI] 10.3389/fmicb.2020.559165 PMC 바로가기 [Article Type] Microbiology
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamidesArticle Published on 2015-11-012023-06-01 Journal: Bioorganic & Medicinal Chemistry [Category] 두창, 수두, 홍역, [키워드] Antiviral Human Cytomegalovirus Non-nucleoside inhibitor uracil Varicella zoster virus. [DOI] 10.1016/j.bmc.2015.09.033 PMC 바로가기