Single Immunization with Recombinant ACAM2000 Vaccinia Viruses Expressing the Spike and the Nucleocapsid Proteins Protects Hamsters against SARS-CoV-2-Caused Clinical Disease스파이크 및 뉴클레오캡시드 단백질을 발현하는 재조합 ACAM2000 백시니아 바이러스를 사용한 단일 면역은 SARS-CoV-2 유발 임상 질병으로부터 햄스터를 보호합니다Article Published on 2022-05-112022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] ACAM2000 Antibody titer Antigen antigens Breakthrough infection candidate clinical Combination competent Continuous COVID-19 COVID-19 vaccine COVID-19 vaccines deleted demonstrated described develop E3L Efficacy ENhance expected expressed expressing hamster hamsters highlight host range human cells immune responses Immunity immunization immunogenic Increasing induce Infection initial innate immune responses intramuscular investigated K3L long-lasting lymphocyte N protein Neutralizing antibody titer neutrophil Neutrophil-to-lymphocyte ratio nucleocapsid nucleocapsid antigen nucleocapsid antigens nucleocapsid protein Nucleocapsid proteins ortholog platform poxvirus Protective Protein recombinant recombinant COVID-19 vaccine Recovery time reduced reduced viral loads replaced SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants shorter recovery time shown significantly spike spike and nucleocapsid proteins the SARS-CoV-2 the Spike the vaccine Vaccine vaccine candidate vaccinia vaccinia virus variants Viral virus virus replication weight loss were expressed [DOI] 10.1128/jvi.00389-22 PMC 바로가기 [Article Type] Article
Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection단일 용량 복제 폭스바이러스 벡터 기반 RBD 백신은 SARS-CoV-2 감염에 대한 강력한 체액 및 T 세포 면역 반응을 유도합니다.Clinical Trial Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration animal models Antigen approach breath complementary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cynomolgus macaques Dose escalation Efficacy evaluate the effect Express humoral immune immune response immune responses immunogenicity induce long-lasting mice Neutralizing antibodies outbreak pandemic poxvirus protective immunity RBD Receptor binding domain Replication respiratory response robust Safe safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus single dose Single-dose Support T cell T cell responses temperature Vaccine vaccine candidate vaccine platform Vaccines vaccinia virus vector [DOI] 10.1016/j.ymthe.2021.10.008 PMC 바로가기 [Article Type] Clinical Trial
Potential of an Eco-Sustainable Probiotic-Cleaning Formulation in Reducing Infectivity of Enveloped VirusesArticle Published on 2021-11-042022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] alpha- and beta-coronavirus antiviral action antiviral property cleaning Contact Contamination COVID-19 pandemic eco-friendly disinfection Effectiveness enveloped virus decontamination European Formulation Human inactive infection control Infectivity influenza viruses overcome pathogen Potential Prevent prevention Probiotic SARS-CoV-2 SARS-CoV-2 inactivation sodium Spread System tested vaccinia virus virus virus spread viruses was tested worsening [DOI] 10.3390/v13112227 PMC 바로가기 [Article Type] Article
Vaccinia virus-based vaccines confer protective immunity against SARS-CoV-2 virus in Syrian hamstersVaccinia 바이러스 기반 백신은 시리아 햄스터에서 SARS-COV-2 바이러스에 대한 보호 면역을 부여합니다.Research Article Published on 2021-09-092022-09-10 Journal: PLoS ONE [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adenovirus-based Beta C57BL/6 candidate Candidates cause caused cold chain Coronavirus-2 Coronaviruses COVID-19 disease effective Express full-length SARS-CoV-2 full-length SARS-CoV-2 spike protein hamster hamsters Human immune response immune responses induce infected individual infected individuals Infection mammalian cells mice Mortality MOST mRNA Neutralizing antibodies neutralizing antibody Prevent protective immunity recombinant vaccine recombinant vaccines regimen regimens respiratory Respiratory illness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 virus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe respiratory illness Spike protein vaccination Vaccine vaccine platform vaccinia vaccinia virus variant Viral viral spread viral strain viral strains virus [DOI] 10.1371/journal.pone.0257191 PMC 바로가기 [Article Type] Research Article
Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination코로나19 후보 벡터백신 MVA-SARS-2-S의 전임상 접종에서 면역원성과 효능423 Published on 2021-07-132022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 비임상, 진단, [키워드] acute respiratory syndrome Adenovirus Administered Antigen approved binding breath candidate vaccine cause CD8 cellular Characteristics children clinical evaluation clinical experience clinical trial component consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccines disease Ebola virus disease economics Efficacy expresse expressing expression full-length SARS-CoV-2 growth Health heterologous prime-boost homologous Human human ACE2 Humoral immunity immunization immunocompromised individuals immunogenicity Infection infectious agent intramuscular investigated MERS-CoV mice Middle East Middle East respiratory syndrome Coronavirus modified vaccinia virus neutralized nonclinical testing pandemic coronavirus Phase I poxvirus produced Protective Protein reached resource respiratory respiratory syndrome coronavirus robust S protein Safe SARS-CoV-2 SARS-COV-2 infection serum antibodies serum antibody Severe acute respiratory syndrome Significance smallpox vaccine stability T cell T cells vaccination Vaccine vaccine vector vaccinia virus vector Virus Disease [DOI] 10.1073/pnas.2026207118 PMC 바로가기 [Article Type] 423
New methylene blue derivatives suggest novel anti-orthopoxviral strategiesArticle Published on 2021-07-012023-06-10 Journal: Antiviral Research [Category] Fulltext, 원숭이두창, [키워드] Antiviral Methylene blue Novel inhibitor PAV-866 poxviruses vaccinia virus [DOI] 10.1016/j.antiviral.2021.105086 PMC 바로가기
SARS_CoV2 RBD gene transcription cannot be driven by CMV promoterSARS_CoV2 RBD 유전자 전사는 CMV 프로모터에 의해 구동될 수 없습니다Article Published on 2021-06-012022-09-11 Journal: Virology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] binding domain biochemical can not Cell chicken CMV CMV promoter conformational COVID-19 Critical cytomegalovirus driven by Evidence Express facilitate functional Gene Expression in vitro information mRNA plasmids portal promoter Protein provided RBD RBD expression RBD gene RBD protein Receptor binding domain SARS_CoV2 Spike protein Support the RBD Transcription transfected with translation Vaccine design vaccinia vaccinia virus virus infection β-actin [DOI] 10.1016/j.virol.2021.02.010 PMC 바로가기 [Article Type] Article
The European tiered approach for virucidal efficacy testing – rationale for rapidly selecting disinfectants against emerging and re-emerging viral diseasesPerspective Published on 2021-01-212022-10-31 Journal: Eurosurveillance [Category] COVID-19, [키워드] acute respiratory syndrome addition Antiviral approach auxiliary Committee complex coronavirus COVID-19 develop Disinfectants effective Efficacy emerging virus European European Standardisation evaluate group hand hygiene hygiene include Infection prevention and control Isolation marker Masks outbreak pandemic physical distancing preventive measure quarantine reduce risk of transmission SARS-CoV-2 Spread surface disinfection vaccination Vaccines vaccinia virus viral disease virucidal virus viruses working [DOI] 10.2807/1560-7917.ES.2021.26.3.2000708 PMC 바로가기 [Article Type] Perspective
Here, There, and Everywhere: The Wide Host Range and Geographic Distribution of Zoonotic OrthopoxvirusesReview Published on 2020-12-302023-05-31 Journal: Viruses [Category] Fulltext, 조류인플루엔자, [키워드] Cowpox virus Monkeypox virus emergent viruses host range orthopoxvirus outbreak Poxviridae vaccinia virus wild and domestic animals zoonosis [DOI] 10.3390/v13010043 PMC 바로가기 [Article Type] Review
SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19SOCS, 내재 독성 인자 및 COVID-19의 치료Review Published on 2020-10-232022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome antagonist antiviral peptide block caused Cell coronavirus COVID-19 COVID-19 pandemic cytokine signaling death Defense effective embryonic Factor Factors herpes simplex herpes simplex virus Herpes Simplex Virus 1 Host HSV-1 IFN IFNγ induce infections inflammatory disease Influenza influenza A influenza A virus inhibit inhibitor inhibitors inhibitory inhibitory activity interferon interferon gamma intrinsic JAK2 kinase kinases KIR leads mechanism mice Neonatal neonatal death Other palmitate pathogenic pathogenic virus penetration peptide phosphorylated Prevent Prophylactic required respiratory SARS-CoV-2 SARS-CoV2 Severe acute respiratory syndrome shown SOCS1 SOCS3 Spike protein STAT STATs suppressor therapeutic transcription factor TYK2 type I tyrosine tyrosine kinase vaccinia virus Viral Viral virulence virulence virulence factors virus virus pathogenesis viruses [DOI] 10.3389/fimmu.2020.582102 PMC 바로가기 [Article Type] Review