Understanding Hepatitis B Virus Dynamics and the Antiviral Effect of Interferon Alpha Treatment in Humanized Chimeric MiceArticle Published on 2021-06-242023-06-12 Journal: Journal of Virology [Category] B형 간염, Fulltext, [키워드] Hepatitis B virus humanized chimeric mice IFN-α Interferon alpha mathematical modeling viral kinetics [DOI] 10.1128/JVI.00492-20 PMC 바로가기
Viral Dynamics and Real-Time RT-PCR Ct Values Correlation with Disease Severity in COVID-19Review Published on 2021-06-152022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] addition Affect affected article biochemical markers clinical study clinical utility conducted coronavirus disease correlated correlation COVID-19 Ct values cycle threshold database diagnose Direct discrepancy Disease progression disease severity Dynamics Efficiency Factor false-negative gold standard Google Scholar Interpretation knowledge large sample Mortality nucleic acid extraction patients with COVID-19 positive correlation predict primer Real-time PCR RT-PCR RT-PCR Ct SARS-CoV-2 SARS-COV-2 infection Science searched selected severity specimen storage conditions Swab Transport value variable viral kinetics Viral load viral RNA load [DOI] 10.3390/diagnostics11061091 PMC 바로가기 [Article Type] Review
Mechanistic modelling of SARS-CoV-2 and other infectious diseases and the effects of therapeuticsReview Published on 2021-05-132023-06-15 Journal: Clinical Pharmacology and Therapeutics [Category] MERS, SARS, [키워드] COVID-19 hepatitis C virus HIV Influenza SARS-CoV-2 viral dynamics viral kinetics [DOI] 10.1002/cpt.2160 PMC 바로가기 [Article Type] Review
A Cytopathic Effect-Based Tissue Culture Method for HCoV-OC43 Titration Using TMPRSS2-Expressing VeroE6 CellsResearch Article Published on 2021-05-122022-10-30 Journal: mSphere [Category] Coronavirus, [키워드] 50% tissue culture infectious dose assay Accuracy antibody Cell cell entry cell lines cells complex contribute coronavirus costly CPE Culture culture supernatant Cytopathic effect early stage expressing HCoV-OC43 Human human coronavirus immunoperoxidase indicated infected cell Infection infectious dose IPA observation protease provide Research serine 2 staining substrates TCID time-consuming tissue titration TMPRSS2 transmembrane VeroE6 cell viral kinetics viral titer virus [DOI] 10.1128/mSphere.00159-21 PMC 바로가기 [Article Type] Research Article
Antibody and viral RNA kinetics in SARS-CoV2 infected patients admitted to a Romanian University Hospital of Infectious DiseasesArticle Published on 2021-04-242023-06-17 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, [키워드] Antibody profile COVID-19 SARS-CoV-2 viral kinetics [DOI] 10.1016/j.ijid.2021.04.067 PMC 바로가기 [Article Type] Article
Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational studyObservational Study Published on 2021-04-222022-10-04 Journal: Infection [Category] MERS, SARS, 임상, [키워드] 95% CI acute respiratory distress Adequate Admission adult COVID-19 patient affected analysed Artificial respiration Care Characteristics clinical Clinical course Cohort concentrations Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 nucleic acid testing described disease trajectories duration of hospitalisation duration of symptom enrolled European First wave Healthcare systems hospitalised hospitalised COVID-19 patient hypertension identify IMV Invasive mechanical ventilation IQR knowledge less management mechanical ventilation Patient patients per day prospective observational study Prospective Study required resource Respiratory distress syndrome Result risk factor SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe disease short duration strained supplementary material Symptom Symptom assessment syndrome the SARS-CoV-2 Viral concentration viral kinetics Viral load Virological [DOI] 10.1007/s15010-021-01594-w PMC 바로가기 [Article Type] Observational Study
Using viral load and epidemic dynamics to optimize pooled testing in resource-constrained settingsResearch Article Published on 2021-04-142022-10-04 Journal: Science Translational Medicine [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome addressed Affect approach changes in coronavirus Course detect Efficacy Efficiency eliminated Epidemic evaluated feasibility group identify implementation IMPROVE in vitro Infection infections limitation mathematical nasopharyngeal sample nasopharyngeal specimen offer Patient Prevalence provide reaction reduction in resource resources robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 surveillance SARS-CoV-2 testing sensitivity simple Spread sputum samples Surveillance Swab translated true positive Variation viral kinetics Viral load [DOI] 10.1126/scitranslmed.abf1568 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 re-infection: development of an epidemiological definition from IndiaFrom the Field Published on 2021-03-262022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] Antigen Asymptomatic conducted contribute COVID-19 defined develop eligible patient epidemiological Evidence HCWs healthcare worker India individual literature review magnitude molecular test negative test participant positive Positive test proportion Re-infection Reinfection SARS-CoV-2 SARS-CoV-2 infected individual Surveillance Taking tested to define viable virus viral kinetics viral shedding while [DOI] 10.1017/S0950268821000662 PMC 바로가기 [Article Type] From the Field
Early Viral Clearance and Antibody Kinetics of COVID-19 Among Asymptomatic CarriersMedicine Published on 2021-03-152022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Admission antibody antibody kinetics Antibody Response Asymptomatic Asymptomatic carrier Asymptomatic case Asymptomatic COVID-19 average C-reactive protein carrier changes in children clearance of SARS-CoV-2 Clinical characteristics contribute COVID-19 COVID-19 patient enrolled follow-up period IgA IgG IgG and IgM IgM information initial interleukin-6 Kinetics nasopharyngeal Patient patients peaked positive pre-symptomatic quantitative PCR remained RNA SARS-CoV-2 seropositive Spread Symptom symptomatic patient Symptomatic patients tested the SARS-CoV-2 three groups threshold total antibody transcriptase viral clearance viral kinetics viral nucleic acid was tested without symptom [DOI] 10.3389/fmed.2021.595773 PMC 바로가기 [Article Type] Medicine
Modeling of SARS-CoV-2 Treatment Effects for Informed Drug RepurposingPharmacology Published on 2021-03-102022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antiviral effect approach Artemisinin benefit candidate clinical trial Concentration coronavirus disease COVID-19 Diagnosis disease modeling dosing regimen dropped drug drug candidate Drug repurposing Effect effective explained Host host response human SARS-CoV-2 Hydroxychloroquine immune response in vitro in vitro experiment in vivo Informed Intervention Ivermectin log lung tissue modeling Pharmacometrics profile reduce Repurposed drug repurposing SARS-CoV-2 selected Treatment viral dynamics viral kinetics Viral load were given [DOI] 10.3389/fphar.2021.625678 PMC 바로가기 [Article Type] Pharmacology