viral life cycle – Page 3 – Communicable Diseases Research

Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages

Research Article

Published on 2022-02-082022-10-29
Journal: mBio [Category] COVID-19, MERS,

[키워드] AGER alveolar Alveolar macrophages amplification AT1 AT2 Autopsy caused Cell Cell culture cell line Cellular imaging coronavirus disease COVID-19 detection diagnostics Drug screening FFPE fixation fluorescent image analysis formalin Human human lung tissue human tissue identify infected patients infected with SARS-CoV-2 Infection Localization lung Lymph node macrophage marker Marco marker gene marker genes novel coronavirus SARS-CoV-2 observé ORF1a paraffin embedding pathology performed Placenta platform pneumocyte probe Region regions RNA RNA FISH SARS-CoV-2 SARS-CoV-2 RNA SFTPC Single Cell specimens subcellular subcellular localization subgenomic mRNAs tissue tissues Type viral life cycle Viral RNA widespread
[DOI] 10.1128/mbio.03751-21 PMC 바로가기 [Article Type] Research Article

Profiling Selective Packaging of Host RNA and Viral RNA Modification in SARS-CoV-2 Viral Preparations

Cell and Developmental Biology

Published on 2022-02-032022-10-31
Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19,

[키워드] Cell examined function genomic RNA Host host cells identify in viral isolate mechanism Modification modifications packaged packaging preparation Profiling RNA RNA sequencing RNAs SARS-CoV-2 SARS-CoV-2 viral selective SRP RNA the SARS-CoV-2 Transcriptome transcriptomic transfer RNA tRNA tRNAs uninfected VeroE6 cell viral life cycle viral-host interaction virion virus
[DOI] 10.3389/fcell.2022.768356 PMC 바로가기 [Article Type] Cell and Developmental Biology

CTD of SARS-CoV-2 N protein is a cryptic domain for binding ATP and nucleic acid that interplay in modulating phase separation

SARS-CoV-2 N 단백질의 CTD는 상분리를 조절하는 데 상호작용하는 ATP 및 핵산 결합을 위한 비밀 도메인입니다

Article

Published on 2022-02-012022-09-11
Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), SARS, 변종, 치료법,

Overview of SARS-CoV-2 genome-encoded proteins

SARS-CoV-2 게놈 암호화 단백질 개요

Review

Published on 2022-02-012022-09-11
Journal: Science China. Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

[키워드] accessory proteins acute respiratory syndrome acute respiratory syndrome coronavirus anti-CoV drug assembly atomic level attachment biological impact complexes component coronavirus coronavirus 2 CoV proteins domain Drug discovery ENCODE experimental structure facilitate functional Genome host cell life cycle nucleocapsid nucleotides PDB Prevent Protein Protein Data Bank Proteins Research RNA genome RNA virus SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic SARS-CoV-2 protein SARS-CoV-2 proteins Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity single-stranded Spread structural and functional characterization Structure structure and function-based drug discovery. structures Transcription Vaccine viral genome replication viral life cycle virus
[DOI] 10.1007/s11427-021-1964-4 PMC 바로가기 [Article Type] Review

5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis

5-요오도투베르시딘은 SARS-CoV-2 RNA 합성을 억제합니다

Article

Published on 2022-02-012022-09-11
Journal: Antiviral Research [Category] COVID19(2023년), SARS, 신약개발, 치료제,

[키워드] 6-Thio-dG absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine ADK antiviral activity antiviral drugs caused Compound compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deoxyguanosine drug exhibited Fludarabine Fludarabine Phosphate functional highlight homolog humans Infectious disease inhibit inhibiting inhibitors inhibitory activity life cycle Novel coronavirus nucleotide nucleotide analogs pandemic phosphate presenting RdRP RdRp inhibitors RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA screened severe acute respiratory syndrome Coronavirus urgency viral life cycle
[DOI] 10.1016/j.antiviral.2022.105254 PMC 바로가기 [Article Type] Article

Structural biology of SARS-CoV-2: open the door for novel therapies

SARS-COV-2의 구조 생물학 : 새로운 요법을위한 문을여십시오.

Review

Published on 2022-01-272022-08-31
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] accessory protein Adsorption assembly causative agent caused cellular complexes COVID COVID-19 Critical door drug-target ENCODE Factor Host imperative in viral Infection involved life cycle mechanism member Molecular medicine nucleic acid open Orthocoronavirinae pandemic disease pandemic disease COVID-19 partner physiological activities potential therapy Prevent Protein reagent Replication respiratory RNA genome SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 structural biology Structure structures target proteins the disease Therapies therapy Transcription treat treating COVID-19 Treatment Viral viral infection viral life cycle viral pathogenesis viral variant Viral variants
[DOI] 10.1038/s41392-022-00884-5 PMC 바로가기 [Article Type] Review

Coronavirus RNA Synthesis Takes Place within Membrane-Bound Sites

Article

Published on 2021-12-172022-10-28
Journal: Viruses [Category] COVID-19,

Antiviral Activities of Carbazole Derivatives against Porcine Epidemic Diarrhea Virus In Vitro

Article

Published on 2021-12-162022-10-28
Journal: Viruses [Category] Coronavirus,

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Article

Published on 2021-12-102022-10-04
Journal: Nature Communications [Category] SARS, 유전자 메커니즘,

SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response

Article

Published on 2021-12-092022-10-28
Journal: Viruses [Category] COVID-19, SARS,