Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry액체 크로마토그래피-탠덤 질량분석기를 이용한 SARS-CoV-2를 포함한 8종의 인간 호흡기 바이러스 동시 모니터링Article Published on 2022-08-042022-09-11 Journal: Scientific Reports [Category] SARS, 신종인플루엔자, 진단, 치료기술, 치료제, [키워드] 229E absence acute infection acute respiratory syndrome coronavirus applied Chain Reaction characterisation clinical sample clinical samples conditions coronavirus 2 Coverage Culture Diagnosis eight H1N1 H3N2 human respiratory virus Infection Influenza Influenza A/H1N1 influenza B information liquid Liquid chromatography mass spectrometry moderate not used nucleoprotein OC43 Orf9b peptide peptides polymerase chain polymerase chain reaction positive presence or absence Protein proteomics provide Replication respiratory respiratory virus respiratory viruses reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 ORF9b serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Simultaneous specimens Tandem mass spectrometry the SARS-CoV-2 transcriptase viral infection Viral load Viral protein Viral proteins Viral RNA virus virus replication [DOI] 10.1038/s41598-022-16250-y PMC 바로가기 [Article Type] Article
Emergence of immune escape at dominant SARS-CoV-2 killer T cell epitope우성 SARS-CoV-2 킬러 T 세포 에피토프에서 면역 탈출의 출현Article Published on 2022-08-042022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antigen CD8 CD8 T cell Cohort cohorts convalescent patient Convalescent patients coronavirus COVID-19 dominant emergence epitope Epitopes for inclusion Frequency glycoprotein highlighting HLA human leukocyte antigen immune Immune escape individual leukocyte Lineage lineages mounted Mutation new SARS-CoV-2 Next generation vaccine next generation vaccines peptide-HLA Phylogenetic prevalent Protein response SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 spike SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus spike spike glycoprotein T cell T cell epitope T cell epitopes T cell receptors vaccine immunity variants viral escape Viral protein Viral proteins [DOI] 10.1016/j.cell.2022.07.002 PMC 바로가기 [Article Type] Article
CoVM 2: Molecular Biological Data Integration of SARS-CoV-2 Proteins in a Macro-to-Micro MethodCoVM 2: 거시적 방법에서 SARS-CoV-2 단백질의 분자 생물학적 데이터 통합Article Published on 2022-08-022022-09-11 Journal: Biomolecules [Category] SARS, 변종, 치료기술, [키워드] accumulated addition Affect analyzed association B.1.617.2 binding binding affinity binding state Biological calculated causative agent changes in collected COVID-19 COVID-19 pandemic crystal structure crystal structures Data integration Delta docking examined glycoprotein human proteins human receptor human receptors information integration Interaction lack macro molecular Molecular biology Multiple Mutation omicron physical PPI network Protein protein interaction protein structure protein structure docking protein-protein interaction public health receptor protein Research S protein S proteins SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins selected sequence strain Structure structures variant variants Viral protein Viral proteins virus–host interactions [DOI] 10.3390/biom12081067 PMC 바로가기 [Article Type] Article
FURIN gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe COVID-19심각한 COVID-19에서 사망 및 심혈관 특성의 잠재적 마커로서의 FURIN 유전자 변이체(rs6224/rs4702)Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition age allele association candidate Candidates cleaving COVID-19 COVID-19 patient COVID-19 patients death death case diabetes DNA variant DNA variants evaluated expression functional furin FURIN gene gene polymorphism Genotype genotyped Haplotype Homozygosis hypercholesterolemia hypercholesterolemia. hyperlipidaemia hypertension increased risk independent risk factor independent risk factors Infection infection cycle intensive care intensive care unit Logistic regression marker multiple logistic regression Odds ratio physiological protease regulate risk risk of death SARS-CoV-2 severe COVID-19 significantly significantly increased statistically susceptibility traits variant Viral protein Viral proteins virus [DOI] 10.1002/jmv.27748 PMC 바로가기 [Article Type] Article
Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen공분산은 인간 병원체로서 SARS-CoV-2의 출현과 지속적인 진화에 중요한 보존된 단백질 잔기 상호작용을 예측합니다Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] allele alleles Amino acid amino acid residue amino acid residues Analysis approach caused change Combination comprehensive analysis conserved coronavirus CoV CoV genome covariance CoVs difference dominant Epidemics Evolution Evolution of SARS-CoV-2 exhibited followed by Frequency Genome host adaptation human pathogen implicated incrementally independent Interaction Lineage lineages nucleotide occurred Pandemics Pathogens predict Protein protein sequence Region reservoirs residue SARS-CoV-2 SARS-CoV-2 variants statistically unique Viral protein Viral proteins β-coronavirus β-Coronaviruses [DOI] 10.1371/journal.pone.0270276 PMC 바로가기 [Article Type] Article
The global succinylation of SARS-CoV-2-infected host cells reveals drug targetsSARS-CoV-2에 감염된 숙주 세포의 세계적인 숙시닐화는 약물 표적을 드러낸다Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료법, 치료제, [키워드] Analysis Antiviral antiviral drug antiviral drug target antiviral effects antiviral therapies Caco-2 Caco-2 cells causative agent cellular cellular pathway cellular pathways conserved COVID-19 COVID-19 pandemic demonstrated drug target enzyme Evolution highlighting Host host cell host protein inhibit inhibitor Interaction mechanism membrane protein Membrane proteins metabolic pathways Modification nsp14 overexpressed promote Protein Quantitative regulated Regulatory reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SIRT5 sirtuin succinylproteomics. variants Viral proteins virus replication [DOI] 10.1073/pnas.2123065119 PMC 바로가기 [Article Type] Article
Imaging Techniques: Essential Tools for the Study of SARS-CoV-2 Infection영상 기술: SARS-CoV-2 감염 연구를 위한 필수 도구Review Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 치료기술, [키워드] COVID-19 COVID-19 pandemic death diagnostic Essential fluorescence microscopy functional functional studies high content screening high resolution Host imaging In vitro studies in vitro study Interaction Microscopy models new virus observation patients power reagent reagents RT-PCR SARS-CoV-2 SARS-CoV-2 detection Super-resolution Viral protein Viral proteins Virology virus [DOI] 10.3389/fcimb.2022.794264 PMC 바로가기 [Article Type] Review
Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by portable wireless graphene biosensor휴대용 무선 그래핀 바이오센서를 통한 타액 내 처리되지 않은 SARS-CoV-2 바이러스 및 그 변이체의 신속한 자가 테스트Article Published on 2022-07-122022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aptamer biosensor clinically Cognate Concentration coronavirus COVID-19 D614G detect determined by diagnostic DNA domain early phase environmental monitoring epidemiological epidemiologically field-effect transistor Graphene limit limit of detection LoQ MERS Middle East Middle East respiratory syndrome N protein N501Y nucleocapsid omicron pandemic plaque plaque-forming unit platform positive Precision Protein Proteins public health quantitation Rapid RBD Receptor-binding domain respiratory RT-PCR S protein Saliva saliva samples SARS-CoV-2 SARS-CoV-2 variant sensitivity sensor severe acute respiratory syndrome coronavirus 2 significantly lower specificity Spike protein statistically variant variants of concern viral particle Viral particles Viral proteins virus Y453F [DOI] 10.1073/pnas.2206521119 PMC 바로가기 [Article Type] Article
Variations of SARS-CoV-2 in the Iranian population and candidate putative drug-like compounds to inhibit the mutated proteinsResearch article Published on 2022-07-112022-10-05 Journal: Heliyon [Category] 신약개발, [키워드] addition Affect antibody appear Ardabil benefit Candidate putative drug-like compounds Ciclesonide complex Compound conserved COVID-19 diagnosing DNA docked element Evolution Frame Genetic Genetic variant help indels indicated inducer Infection inhibit inhibitor Interaction Iran mechanism of action Meta-analysis mutated Mutation Nonstructural proteins (NSPs) Novel coronavirus NSP8 nucleotide nucleotide mutation Open reading frame (ORF) ORF1ab Orf9b Oxford polyproteins Potential Protein reported responsible resveratrol SARS-CoV-2 SARS-CoV-2 gene sequence sequenced Spread Substitution the SARS-CoV-2 Topic treating COVID-19 Vaccine design Viral proteins viral replication virus Wuhan, China [DOI] 10.1016/j.heliyon.2022.e09910 [Article Type] Research article
Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins25-하이드록시콜레스테롤의 항바이러스 분자 메커니즘 연구: 콜레스테롤 항상성 교란 및 단백질의 번역 후 변형Review Published on 2022-07-052022-09-11 Journal: European journal of pharmacology [Category] 치료제, [키워드] 25-Hydroxycholesterol activating Antiviral antiviral activity antiviral drug antiviral drugs Antiviral mechanism binding catalyzed cholesterol cholesterol homeostasis contribute coronavirus disease Coronavirus disease 2019 Efficiency efficient endoglycosidase endosomal pathway global public health glycan glycans glycosylation hydroxylase impair in vitro in vivo inhibiting Innate immunity Lipid Lipid raft liver Maturity mechanisms Modification molecular mechanism nucleic acid outbreak oxysterol oxysterol-binding protein pathway post-translational modification prenylation Previous studies previous study Protein reactive receptor reduce restrict second sensitivity shown Sterol Toxicity Viral protein Viral proteins virus [DOI] 10.1016/j.ejphar.2022.175033 PMC 바로가기 [Article Type] Review