The Impact of Real-Time Whole-Genome Sequencing in Controlling Healthcare-Associated SARS-CoV-2 OutbreaksMajor Articles and Brief Reports Published on 2022-01-012022-10-29 Journal: The Journal of Infectious Diseases [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Admission affected Analysis Asymptomatic classical Cluster Community contributed controlling coronavirus epidemic wave epidemiological data Epidemiology events excluded Genetic epidemiology high-risk area hospital identify Impact incidence Infection infection control Infection prevention initial instance Intervention measure Measures nosocomial Nosocomial transmission outbreak pandemic Patient point-of-care resource resources SARS-CoV-2 Sequencing significantly Transmission viral sequence virus WGS whole-genome sequencing whole-genome sequencing: COVID-19 [DOI] 10.1093/infdis/jiab483 PMC 바로가기 [Article Type] Major Articles and Brief Reports
The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study알파 변종은 영국의 다기관 병원 연구에서 과도한 병원 내 SARS-CoV-2 감염과 관련이 없었습니다.Multicenter Study Published on 2021-12-012022-09-10 Journal: The Journal of Infection [Category] MERS, SARS, 변종, [키워드] Alpha Alpha variant caused COG-UK collected Community community acquired COVID-19 determine Effect Efficacy epidemiological data Evidence genetic difference healthcare hospital hospitals Infection Infection prevention infections information investigated involved less Lineage Lineage B.1.1.7 lineages Logistic regression analysis measure nine no significant difference nosocomial Nosocomial outbreaks Nosocomial transmission objective outbreak overlapping Patient reassurance Result SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants sequence sequence similarity Spread Support Transmissibility Transmission UK hospital UK hospitals variants of concern Viral viral sequence viral sequences [DOI] 10.1016/j.jinf.2021.09.022 PMC 바로가기 [Article Type] Multicenter Study
Integration of SARS-CoV-2 RNA in infected human cells by retrotransposons: an unlikely hypothesis and old viral relationshipsCommentary Published on 2021-10-292022-10-29 Journal: Retrovirology [Category] COVID-19, MERS, SARS, [키워드] available data Chimeric RNA COVID19 DNA elements explain HERV HERV-W human cell Hypothesis integration L1 LINE Patient persistence reported Retrotransposition retroviral SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 RNA Topic unlikely viral sequence virus virus replication [DOI] 10.1186/s12977-021-00578-w PMC 바로가기 [Article Type] Commentary
Intra-host evolution during SARS-CoV-2 prolonged infectionRapid Communication Published on 2021-09-292022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] acquisition acute respiratory syndrome Analysis average Cluster Cohort complex coronavirus coronavirus disease Course COVID-19 COVID-19 pandemic cycle threshold Defense different time points Direct driven by elevated enzyme Evidence Evolution Evolution of SARS-CoV-2 genomic Healthcare professional Helicase helicase gene Host host cell Host immune response Infection innate immune Innate immunity Interaction Intra-host diversity iSNV iSNVs many case mechanism missense variant Mutation nasopharynx non-structural protein pandemic pathogen Patient persist persistence polymerase chain positive positively correlated predicted profile Prolonged infection Protein reactive recent remained reverse transcription RNA-editing enzymes RT-PCR SARS-CoV-2 sequence Single nucleotide variant spike spike gene Spread suggested symptoms onset T cell epitopes Transmission variant Viral load viral sequence virus [DOI] 10.1093/ve/veab078 PMC 바로가기 [Article Type] Rapid Communication
SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort studySARS-COV-2 계보 B.1.1.7은 입원 여성의 질병 심각성이 높지만 남성이 아닌 : Multicentre Cohort StudyMulticenter Study Published on 2021-09-202022-09-10 Journal: BMJ Open Respiratory Research [Category] SARS, 변종, [키워드] 95% CI adjusted Admission age all-cause mortality Analysis B.1.1.7 Care carried Clinical data Clinical outcome clinical outcomes cohort study collected Community Comorbidities COVID-19 COVID-19 infection COVID-19 infections Cox model disease severity Effect eight Ethnicity evaluated female finding greater hospital hospitalised hospitalised patient Hospitalised patients increase in increased risk Inpatient Intensive intensive care less Lineage lineages male Mortality multicentre outcome Patient positive Pregnancy SARS-CoV-2 SARS-CoV-2 lineage sequence Sex subject therapy Transmission variant Viral viral infection viral sequence viral sequences women [DOI] 10.1136/bmjresp-2021-001029 PMC 바로가기 [Article Type] Multicenter Study
VirusViz: comparative analysis and effective visualization of viral nucleotide and amino acid variantsVirusViz: 바이러스 뉴클레오티드 및 아미노산 변이체의 비교 분석 및 효과적인 시각화Comparative Study Published on 2021-09-072022-09-10 Journal: Nucleic Acids Research [Category] SARS, 변종, [키워드] Amino acid amino acids Analysis analyzed build comparison Comparisons COVID-19 pandemic Critical Data analysis database Dengue descriptions Ebola effective group highlighting include indicated information input management MERS-CoV Metadata Mutation nucleotide nucleotides Population predicted producing Region reported Research SARS-CoV SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 variants selected sequence sequences Support switching variant variants Viral viral evolution viral nucleotide viral sequence viral sequences [DOI] 10.1093/nar/gkab478 PMC 바로가기 [Article Type] Comparative Study
Prolonged detection of complete viral genomes demonstrated by SARS-CoV-2 sequencing of serial respiratory specimens연속 호흡기 시편의 SARS-COV-2 시퀀싱에 의해 입증 된 완전한 바이러스 게놈의 장기 검출Research Article Published on 2021-08-052022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced disease can not clinically Complete confirmed case confirmed cases coronavirus COVID19 patient COVID19 patients demonstrated Diagnosis disease stage early stage gene target Infection initial mapped methodology MONITOR N gene nCoV NGS positive Prevent Prolonged RdRP Real-time PCR reduced required respiratory respiratory sample respiratory specimen SARS-CoV-2 SARS-CoV-2 sequencing sequence Sequencing severe acute respiratory syndrome Coronavirus Spread Stage stages tested the disease the SARS-CoV-2 Transcription triplex Viral viral genome viral sequence viral sequences Viral transmission whole genome [DOI] 10.1371/journal.pone.0255691 PMC 바로가기 [Article Type] Research Article
Human MicroRNAs Interacting With SARS-CoV-2 RNA Sequences: Computational Analysis and Experimental Target ValidationGenetics Published on 2021-06-072022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] 501Y.V2 A549 cell acute respiratory syndrome affecting Anti-viral applied B.1.1.7 binding bioinformatics cellular miRNA conserved contributing to coronavirus COVID-19 criteria diagnostic eight experimental evidence expressed expression FIVE host cells host miRNA Human humans Interaction luciferase activity lung microRNA miRNA miRNAs molecular mechanism non-coding RNA pandemic Pathogenesis predicted provide reduction reporter plasmid repress respiratory disorder RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 sequences sequence South Africa spike target therapeutic intervention transfecting transfection United Kingdom validation variant viral sequence viral sequences virus virus infection World Health Organization [DOI] 10.3389/fgene.2021.678994 PMC 바로가기 [Article Type] Genetics
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues역전사된 SARS-CoV-2 RNA는 배양된 인간 세포의 게놈에 통합될 수 있으며 환자 유래 조직에서 발현될 수 있습니다.422 Published on 2021-05-252022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 3′ end absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 can not cellular chimeric chimeric RNAs clinical recovery Consensus contribute coronavirus COVID-19 Culture DNA duplication Evidence explain expressed fraction fusing Genome genomic integration help host cell human cell human cells Hypothesis in some infected cell Infection Infectious virus initial integration integration sites investigated LINE1 majority mechanism Patient patients PCR PCR-positive positive positive PCR test produced Prolonged recurrence reported respiratory reverse transcription RNA SARS-CoV-2 SARS-CoV-2 disease SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RNA SARS-CoV-2 sequence SARS-CoV-2 sequences sequence severe acute respiratory syndrome Coronavirus Significance Support tissue tissues transcribed transcript Transcription transcripts Viral viral genome viral replication Viral RNA viral sequence viral sequences viral transcript viral transcripts [DOI] 10.1073/pnas.2105968118 PMC 바로가기 [Article Type] 422
A rapid, accurate, scalable, and portable testing system for COVID-19 diagnosisCOVID-19 진단을 위한 빠르고 정확하며 확장 가능한 휴대용 테스트 시스템Article Published on 2021-05-182022-09-10 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] Accuracy amplified Assay systems battery Biochemical assays Combination COVID-19 diagnosis COVID-19 testing detect diagnostics E gene followed by isothermal amplification limit of detection Loop-mediated isothermal amplification Mechanical engineering N gene positive sample reverse transcriptase RT-LAMP Saliva saliva samples SARS-CoV-2 sensitivity sequence specificity speed Viral viral sequence viral sequences [DOI] 10.1038/s41467-021-23185-x PMC 바로가기 [Article Type] Article