A machine learning-based approach to determine infection status in recipients of BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys혈청학적 조사를 위한 BBV152(Covaxin) 전체 비리온 비활성화 SARS-CoV-2 백신의 수혜자의 감염 상태를 결정하기 위한 기계 학습 기반 접근 방식Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 치료법, [키워드] age antibody antigens applied approach assessment assessments BBV152 Breakthrough infection can be used Clustering Consensus Covaxin COVID-19 COVID-19 pandemic Data science dataset Delta determine dose doses effective Effectiveness Ensemble methods generate help immune response inactivated Infection machine machine learning ML model neutralization Neutralization assay neutralize nucleocapsid antigens Population predicted premise Protein random recipient recipients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV-2. sequence sequences serological survey Sex spike Spike protein statistical subject subjects subset Support the vaccine type strain uninfected Vaccine vaccine response viral evolution Viral proteins virion wild type wild-type strain [DOI] 10.1016/j.compbiomed.2022.105419 PMC 바로가기 [Article Type] Article
A trifunctional peptide broadly inhibits SARS-CoV-2 Delta and Omicron variants in hamsters Research Published on 2022-06-302022-10-05 Journal: Cell Discovery [Category] 치료제, [키워드] Antiviral antiviral activity block cellular Clustering concern COVID-19 cases Delta delta variant Endocytic pathway hamster hamsters in vitro inhibit inhibiting lung viral titer Lungs membrane fusion omicron peptide Prevent reduce reduction required SARS-CoV-2 SARS-CoV-2 variant significantly syncytia formation the SARS-CoV-2 trifunctional variant viral entry virion virus VOCs [DOI] 10.1038/s41421-022-00428-9 [Article Type] Research
Electrostatic Map of the SARS-CoV-2 Virion Specifies Binding Sites of the Antiviral Cationic PhotosensitizerSARS-CoV-2 Virion의 정전기 지도는 항바이러스 양이온 광감작제의 결합 부위를 지정합니다Article Published on 2022-06-302022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] antibodies Antiviral Brownian dynamics coarse-grain model component computational method different materials distribution domain drugs E protein electrostatic electrostatic interactions Electrostatics Glutamate glutamate residue groups heterogeneous host cells Interaction Lipid lipids Map Numerous oxygen photosensitizer photosensitizer. phthalocyanine positive Positive Charge predict Protein Proteins Reactions reactive oxygen SARS-CoV-2 Site Structure target the SARS-CoV-2 understanding viral envelope viral membrane virion virus Zinc [DOI] 10.3390/ijms23137304 PMC 바로가기 [Article Type] Article
Hydrodynamics of spike proteins dictate a transport-affinity competition for SARS-CoV-2 and other enveloped viruses스파이크 단백질의 유체 역학은 SARS-CoV-2 및 기타 외피 바이러스에 대한 수송 친화성 경쟁을 결정합니다Article Published on 2022-06-302022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] Affect affinity distribution Effect explain feature Genetic Hydrodynamics Influenza Interaction mechanism morphology platform reactivity required SARS-CoV-2 sequence spike Spike protein spikes Structure surface protein surface proteins Transmissibility Transport Variability viral infectivity virion virus virus viruses [DOI] 10.1038/s41598-022-14884-6 PMC 바로가기 [Article Type] Article
Virucidal Properties of Photocatalytic Coating on Glass against a Model Human Coronavirus모델 인간 코로나바이러스에 대한 유리의 광촉매 코팅의 바이러스 살균 특성Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] added aerosol alteration Antiviral antiviral activity can not coated with coating construction Contact Contagion Contamination coronavirus coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damaged deformation Disruption electron microscopy element Epidemiology Evidence evidence of exposure to glass Human coronavirus human coronavirus human coronaviruses in-depth analysis inactivation increase infectious investigated Kinetics knowledge Masks Microscopy mitigate Model morphologically pandemic performed Photocatalysis photocatalytic coating physical physical barrier property Protective protective effect Protective effects reduced reducing Research SARS-CoV-2 Spread suggested surface titanium titanium dioxide Transmission viral envelope virion virions virucidal virucidal activity. virus virus virus spread virus titer viruses [DOI] 10.1128/spectrum.00269-22 PMC 바로가기 [Article Type] Article
Neutralizing antibody activity against SARS-CoV-2 variants in gestational age-matched mother-infant dyads after infection or vaccination감염 또는 예방 접종 후 재태 연령이 일치하는 모자에서 SARS-CoV-2 변이체에 대한 중화 항체 활성Article Published on 2022-06-222022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adaptive immunity age analyzed antibody COVID-19 Delta disease during pregnancy effective elicit first trimester gestation gestational age immune response immune responses immunoglobulins individuals Infection Infectious disease Infectious disease. less mother mRNA vaccine mRNA vaccines NAb NAbs neutralization neutralization activity Neutralizing plasma plasma sample Pregnancy pregnant Protein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccination SARS-CoV-2 variant second trimester sequence Spike protein spike variants time of delivery transfer unique vaccination Vaccine variant virion was measured with infection women WT spike [DOI] 10.1172/jci.insight.157354 PMC 바로가기 [Article Type] Article
RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIaRANBP2 및 USP9x는 아데노바이러스 마이너 코트 단백질 IIIa의 핵 수입을 조절합니다Article Published on 2022-06-162022-09-11 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] accumulation acute respiratory illness acute respiratory illnesses Adenovirus Affinity purification Amino acid amino acids Analysis analysis antiviral therapeutics antiviral therapy bind binding blockade C-terminus Cell cell nuclei cells cellular competition conjunctivitis counteract COVID-19 demonstrated deregulated disparate expression Host implication indicated infected cells Infection interact Interaction interactions mass spectrometry maturation mechanism Microscopy nuclear nuclei nucleus outbreak parasites protease Protein Proteins Ranbp2 reduced regulate respiratory pathogen retention subsequent surface plasmon surface plasmon resonance transmission electron microscopy Transport USP9x Vaccine viral genome replication Viral particles Viral protein virion virion assembly virus virus-infected cell virus-infected cells wild type [DOI] 10.1371/journal.ppat.1010588 PMC 바로가기 [Article Type] Article
Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529신흥 SARS-CoV-2 변이체 B.1.1.529의 스파이크 당단백질의 기능적 특성Article Published on 2022-06-142022-09-11 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 affinity ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 B.1.1.529 B.1.617.2 Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CP: Immunology CP: Microbiology cytopathic effects D614G decrease exhibit functional glycoprotein higher affinity immune evasion immunology Infection less Microbiology neutralization neutralization sensitivity omicron Patient prevalent processing property pseudovirus pseudoviruses relative S glycoprotein S glycoproteins S trimer S1 shedding SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera severe acute respiratory syndrome Coronavirus spike glycoprotein stability syncytium formation temperature TMPRSS2 TMPRSS2 expression Transmission unliganded vaccinees variant variants variants. virion [DOI] 10.1016/j.celrep.2022.110924 PMC 바로가기 [Article Type] Article
Photodynamic Inactivation of SARS-CoV-2 Infectivity and Antiviral Treatment Effects In VitroSARS-CoV-2 감염의 광역학적 비활성화 및 시험관 내 항바이러스 치료 효과Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antibody Antiviral Antiviral agents approach Cell cell cultures cell viability Concentration coronavirus Coronavirus-2 COVID-19 Critical Culture current death detectable Effect heat-inactivated in vivo inactivation Infection infectiousness Infectivity log measure Microscopy mitochondrial Mutation near-infrared light pandemic Pathogens PDI photodynamic inactivation photodynamic therapy photosensitizer photosensitizer. Potential treatment qPCR reduce reduced reduction required SARS SARS-CoV-2 SARS-CoV-2 isolate severe acute respiratory syndrome Coronavirus severe disease significantly THPTS Toxicity Treatment uninfected Vaccines variety Vero Cell viability viral cytopathic effect viral infection viral infections Viral load Viral RNA virion virus virus load virus suspension viruses were assessed [DOI] 10.3390/v14061301 PMC 바로가기 [Article Type] Article
Potential Use of Tea Tree Oil as a Disinfectant Agent against Coronaviruses: A Combined Experimental and Simulation Study코로나바이러스에 대한 소독제로 티트리 오일의 잠재적 사용: 결합된 실험 및 시뮬레이션 연구Article Published on 2022-06-122022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] 1,8-cineole absence accelerated agent Antifungal antiviral activity antiviral properties Combined Complete components Compound Contamination coronavirus COVID-19 pandemic demonstrated disinfectant disinfectant agent Dynamics Effect effective essential oil fusion GaMD glycoprotein HCoV HCoV-OC43 Human coronavirus human coronavirus OC43 limit mechanism mechanism of action Melaleuca alternifolia membrane molecular dynamics molecular dynamics simulations Oil performed Potential Protein Safe SARS-CoV-2 SARS-CoV-2 envelope Simulation spike glycoprotein tea Tea tree oil tea tree oil. terpinen-4-ol the SARS-CoV-2 the Spike tree viral entry virion virucidal [DOI] 10.3390/molecules27123786 PMC 바로가기 [Article Type] Article