Investigation of target sequencing of SARS-CoV-2 and immunogenic GWAS profiling in host cells of COVID-19 in Vietnam베트남 코로나19 숙주 세포에서 SARS-CoV-2 표적 염기서열 분석 및 면역원성 GWAS 프로파일링Article Published on 2022-06-192022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] affected AUC Biomarker clade clinical outcomes comprehensive analysis coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity COVID-19 treatment dataset delta variant Disease progression downstream analysis Elastic forest framework global pandemic GWAS Health Healthcare system Healthcare systems high accuracy Hospitalization host cell host cells immune response immune responses immunogenic Impact investigated investigation Predictive Predictive model prevalent Previous studies previous study progression Protein provided PRS Random forest Research risk risk score SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence Sequencing severity severity of COVID-19 SNP SVM the disease therapeutic target therapeutic targets Treatment Vietnam virus virus variant virus variants [DOI] 10.1186/s12879-022-07415-1 PMC 바로가기 [Article Type] Article
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article
Untangling the changing impact of non-pharmaceutical interventions and vaccination on European COVID-19 trajectories유럽 COVID-19 궤적에 대한 비약물적 개입 및 백신 접종의 변화하는 영향 파악Article Published on 2022-06-032022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] 95% confidence interval approach Bayesian inference Combination combined effect complementary concerning confidence interval coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 transmission dataset declined Effectiveness effort epidemiological Europe European Factor Intervention less NPI NPIs pandemic parameters reduce reduced reducing reduction in Relaxation remains uncertain Reproduction number targets trajectory Transmission vaccination vaccination rates Vaccination strategies Vaccine Vaccines variants virus variants [DOI] 10.1038/s41467-022-30897-1 PMC 바로가기 [Article Type] Article
Modelling the COVID-19 epidemic and the vaccination campaign in Italy by the SUIHTER modelResearch article Published on 2022-06-012022-10-05 Journal: Infectious Disease Modelling [Category] 변종, [키워드] analyses clinical evidence compartmental model COVID-19 COVID-19 epidemic COVID-19 pandemic death dominant Efficacy epidemiological Evolution extension feature Forecast Hospitalization Italy Prevent Scenario analyses Transmission transmission rate vaccination Vaccine variant virus variants [DOI] 10.1016/j.idm.2022.03.002 [Article Type] Research article
Risk Prediction for Acute Kidney Injury in Patients Hospitalized With COVID-19Research article Published on 2022-06-012022-10-05 Journal: Kidney Medicine [Category] 바이오마커, [키워드] 95% CI Acute kidney injury acute respiratory syndrome added age AKI baseline changes in coding Cohort cohort study cohorts comorbid condition conditions coronavirus coronavirus disease COVID-19 creatinine criteria D-dimer levels defined delta variant develop exposure ferritin Final High-sensitivity C-reactive protein hospital hospitalized patient Improving inflammatory biomarkers KDIGO Kidney injury laboratory data limitation longitudinal measure median Model model validation objective participant Patient patients patients hospitalized polymerase chain positive Potential predict prediction Predictive Predictive model rationale Result setting Vaccine validation cohort virus variants with COVID-19 [DOI] 10.1016/j.xkme.2022.100463 [Article Type] Research article
Augmented neutralization of SARS-CoV-2 Omicron variant by boost vaccination and monoclonal antibodies추가 백신 접종 및 단일 클론 항체에 의한 SARS-CoV-2 Omicron 변이체의 증강 중화Article Published on 2022-06-012022-09-11 Journal: European Journal of Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody Antibody binding appearance approved binding BNT162b2 boost boost immunization candidate caused clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Delta delta variant determine dominant Effective vaccines Efficacy Evidence flow cytometry immunization increase MONITOR monoclonal antibodies monoclonal antibody neutralization Neutralization assay neutralization assays neutralize neutralized Neutralizing neutralizing antibody omicron Omicron variant Omicron variants parental pathogenicity Protective pseudotyped SARS-CoV-2 recognize respiratory SARS-CoV-2 SARS-CoV-2 variants serum antibodies serum antibody serum titer serum titers severe acute respiratory syndrome Coronavirus Support therapeutic therapeutic antibodies titers Transmissibility vaccination Vaccine variant variants virus variant virus variants Wuhan strain [DOI] 10.1002/eji.202249841 PMC 바로가기 [Article Type] Article
Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 MouseArticle Published on 2022-05-112023-06-14 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, [키워드] COVID-19 Encephalitis influenza A virus coinfection microgliosis mouse model severe acute respiratory syndrome coronavirus 2 virus variants [DOI] 10.3390/v14051020 PMC 바로가기 [Article Type] Article
Impact of COVID-19 immunisation on COVID-19 incidence, hospitalisations, and deaths by age group in Germany from December 2020 to October 20212020년 12월부터 2021년 10월까지 독일의 연령대별 COVID-19 예방접종이 COVID-19 발병률, 입원 및 사망에 미치는 영향Article Published on 2022-05-092022-09-11 Journal: Vaccine [Category] 변종, [키워드] age all age group all age groups circulation Course Coverage COVID-19 COVID-19 incidence death declined ecological examined Germany group hospitalisation hospitalisations immunisation Impact incidence increase investigated lockdown restriction lockdown restrictions Measures morbidity morbidity and mortality National Public public health Surveillance surveillance data virus variant virus variants [DOI] 10.1016/j.vaccine.2022.04.002 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Pandemic Tracing in Italy Highlights Lineages with Mutational Burden in Growing Subsets이탈리아의 SARS-CoV-2 전염병 추적, 증가하는 하위 집합에서 돌연변이 부담이 있는 계보 강조Article Published on 2022-04-092022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Amino acid amino acid change analysed Analysis appearance burden clades country COVID-19 pandemic database detect develop Evolution genomic Helicase help Italian patient Italian patients Italy management methyltransferase modulation MONITOR mutated Nsp12 Nsp3 nsp4 NSP6 ORF1ab ORF3a ORF8 pandemic Positive selection RdRP SARS-CoV-2 selection pressure Spike proteins Spread spreading Structural variation subpopulation tracing trees variant variant of concern (VOC) variants Viral proteins viral sequence viral sequences viral variant viral variants tracing. virus variant virus variants VoC [DOI] 10.3390/ijms23084155 PMC 바로가기 [Article Type] Article
SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial CellsSMYD2 억제는 인간 장 및 기도 상피 세포에서 TMPRSS2를 하향 조절하고 SARS-CoV-2 감염을 감소시킵니다Article Published on 2022-04-082022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] antiviral activity Antiviral treatment antiviral treatment. AZ505 BAY598 block caused cellular circulating COVID-19 COVID-19 pandemic cultured cell cultured cells curtail decrease deficiency delta variant detectable downregulate effective antiviral treatment Effective vaccines exhibit expresse had no Human infect inhibited inhibition inhibitor lysine mRNA Neutralizing antibodies neutralizing antibody no effect not express pharmacological priming protein levels reporter SARS-CoV-2 SARS-COV-2 infection significantly SMYD2 Spike protein target cells targeting the spike protein TMPRSS2 TMPRSS2 expression Treatment variant Vero E6 VERO E6 cells Viral viral replication virus virus replication virus variant virus variants [DOI] 10.3390/cells11081262 PMC 바로가기 [Article Type] Article