Thromboprophylactic low-molecular-weight heparin versus standard of care in unvaccinated, at-risk outpatients with COVID-19 (ETHIC): an open-label, multicentre, randomised, controlled, phase 3b trialClinical Trial Published on 2022-08-012022-10-05 Journal: The Lancet. Haematology [Category] Coronavirus, Fulltext, MERS, 임상, [키워드] 1:1 105 patient 105 patients adverse event adverse events all-cause mortality analysed Asian assigned Belgium benefit black bleeding event Brazil Clinical practice Complete country COVID-19 COVID-19 vaccine death died dose Efficacy and safety eligibility eligible participant enrolled enrolment evaluate event rate FIVE Follow-up had no hazard ratio hospitalisation hospitalised in both group increased risk India Inflammation intention-to-treat population International IQR main analysis men middle multicentre no difference non-critically ill patient one patient Open-label Outpatient participant Patient patients with COVID-19 Pneumonia primary efficacy endpoint Prophylactic Prophylaxis random randomisation randomised Randomly receive Registered risk factor Safety Safety Monitoring Board Sanofi severe disease severity Sex similar studies South Africa Spain Standard of care Standard-of-care symptom onset symptomatic thromboembolic complications Trial uterine bleeding was done weighed were assessed white with COVID-19 women [DOI] 10.1016/S2352-3026(22)00173-9 PMC 바로가기 [Article Type] Clinical Trial
Durability of Heterologous and Homologous COVID-19 Vaccine Boosts이종 및 동종 COVID-19 백신의 내구성 향상Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenovirus age Analysis Antibody Response Antibody responses Asian assays binding black BNT162b2 BNT162b2 vaccine boost Boston CD4+ T-cell CD8+ Cellular immune response cellular immune responses cohort study COVID-19 COVID-19 vaccine cytokine Data analysis declined elicited evaluate evaluated female Follow-up functional antibody response Heterologous heterologous prime-boost Hispanic homologous humoral humoral immune responses immune response immune responses immunization immunogenicity individual intracellular cytokine staining involved IQR Latino Massachusetts median Messenger RNA mRNA mRNA vaccine Neutralizing neutralizing antibodies titer neutralizing antibody occurred of BNT162b2 omicron outcome participant peaked potential benefit potential benefits prime-boost regimen rapid increase regimen repeated response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants T-cell responses These data Vaccine was performed were assessed white [DOI] 10.1001/jamanetworkopen.2022.26335 PMC 바로가기 [Article Type] Article
Preadmission Statin Treatment and Outcome in Patients Hospitalized With COVID-19Research article Published on 2022-08-012022-10-05 Journal: The American journal of cardiology [Category] 바이오마커, 임상, 치료법, [키워드] added Admission Adult patient age association Atherosclerosis atherosclerotic C-reactive protein cardiovascular disease Cerebrovascular disease Clinical characteristics Clinical outcome confidence interval Coronary artery disease COVID-19 criteria death Diagnosis disease Gender Hospitalized In-hospital Inflammation inhibition of inflammation intensive care marker medication multivariable logistic regression myocardial injury observation Odds ratio outcome Patient patients hospitalized reduction in remained responsible statin study inclusion therapy thrombotic complication was related white with COVID-19 women [DOI] 10.1016/j.amjcard.2022.04.045 [Article Type] Research article
Assessment of Clinical and Virological Characteristics of SARS-CoV-2 Infection Among Children Aged 0 to 4 Years and Their Household MembersArticle Published on 2022-08-012022-11-15 Journal: JAMA Network Open [Category] SARS, 변종, 치료기술, [키워드] 95% CI Adults age Alpha variant analyses antibodies Asian assessment Asymptomatic black Characteristics children clinical Cohort collected Community correlated correlation Delta delta variant enrolled Enrollment feature Features female Frequency greater help highest Hispanic household incidence individual Infection Lineage male median member nasal swab not differ nucleocapsid protein number of symptom Older outbreak outcome participant polymerase chain Prevent prospective cohort study Quantitative questionnaire real-time reverse transcriptase RT-PCR RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 lineage SARS-CoV-2 spike significantly submitted Surveillance Symptom symptomatic individual Symptoms variant variants of interest Viral load Virological white Year [DOI] 10.1001/jamanetworkopen.2022.27348 PMC 바로가기
All Public Health is Local: Lessons From Eagle County During the First 2 Years of the Coronavirus Disease-2019 PandemicObservational Study Published on 2022-08-012022-10-05 Journal: Medical care [Category] 임상, [키워드] Administered approach approval baseline baseline characteristics Consequences coronavirus coronavirus disease-2019 country Course COVID-19 COVID-19 case cumulative death death rate Eagle Fatality rate Health status highlight independent intensive care Latinx lesson Local local public health median Metrics observational study outcome pandemic populations Public public health reached reported Research design United State vaccine dose Variation were recorded white Year [DOI] 10.1097/MLR.0000000000001736 PMC 바로가기 [Article Type] Observational Study
Clinical Effect of Early administration of Tocilizumab Following the Initiation of Corticosteroid Therapy for Patients with COVID-19Article Published on 2022-08-012022-10-05 Journal: Journal of infection and chemotherapy : official j [Category] COVID19(2023년), SARS, 임상, 진단, 치료기술, [키워드] acute respiratory syndrome addition administration analyzed baseline blood cell count C-reactive protein caused clinical Clinical characteristics combination therapy coronavirus Corticosteroid corticosteroid therapy corticosteroid treatment Corticosteroids COVID-19 determine drug early administration Effect effective Efficacy evaluated global pandemic groups hospital Hospitalized Initiation maximum body temperature not significantly different oxygen-free day Patient patients with COVID-19 Result SARS-CoV-2 significant decrease significantly higher significantly lower significantly more survival rate Tocilizumab tocilizumab administration treated treating COVID-19 two groups white with COVID-19 Wuhan [DOI] 10.1016/j.jiac.2022.08.021 [Article Type] Article
Understanding the social determinants of health and genetic factors contributing to the differences observed in COVID-19 incidence and mortality between underrepresented and other communitiesReview article Published on 2022-08-012022-10-05 Journal: Journal of the National Medical Association [Category] 바이오마커, 유전자 메커니즘, [키워드] American black Community Complication contributing to coronavirus COVID-19 COVID-19 incidence database determinant disease Factor Genetic Health Health inequity incidence Indigenous peoples inequality information lack Latinx Local median Mortality mortality rate mortality rates outcome resource shown social determinant social determinants of health Support understanding white [DOI] 10.1016/j.jnma.2022.04.002 [Article Type] Review article
Characterization of demographic data, clinical signs, comorbidities, and outcomes according to the race in hospitalized individuals with COVID-19 in Brazil: An observational studyObservational Study Published on 2022-07-252022-10-05 Journal: Journal of Global Health [Category] COVID19(2023년), SARS, 임상, [키워드] 95% CI 95%CI addition age Analysis Asian black Brazil Characteristics characterization Clinical signs clinical symptom Clinical symptoms Comorbidities contribute contributed country COVID-19 pandemic death demographic data demonstrated described Diabetes Mellitus disease disorder Down syndrome Dyspnoea epidemiological evaluated FIVE hematologic Hospitalized immunosuppressive disorder Indigenous peoples individual individuals individuals with COVID-19 intensive care invasive male mechanical ventilation Ministry of Health Neurological disorder Non-invasive Nosocomial infection obesity outcome outcomes oxygen saturation pandemic performed positive result predict predictor renal risk of death RT-PCR SARS-CoV-2 SARS-COV-2 infection white [DOI] 10.7189/jogh.12.05027 PMC 바로가기 [Article Type] Observational Study
Post-recovery COVID-19 and incident heart failure in the National COVID Cohort Collaborative (N3C) study Research Published on 2022-07-152022-10-05 Journal: Nature Communications [Category] 바이오마커, [키워드] association cardiac cardiovascular disease COVID COVID-19 COVID-19 hospitalization COVID-19 infection de novo event examined heart failure Hospitalized increased risk investigated less male median occurred Older outcome over Patient patients hospitalized the United State white with COVID-19 [DOI] 10.1038/s41467-022-31834-y [Article Type] Research
SARS-CoV-2 active infection prevalence and seroprevalence in the adult population of St. Louis County세인트루이스 카운티 성인 인구의 SARS-CoV-2 활성 감염 유병률 및 혈청 유병률Article Published on 2022-07-012022-09-12 Journal: Annals of epidemiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI absence black conducted COVID-19 COVID-19 infection estimate fatality Hospitalization IgG IgG antibodies Infection infection prevalence oversampling PCR Prevalence prevalence of COVID-19 probability survey random remained SARS-CoV-2 Seroprevalence Weighting were infected white widespread with COVID-19 [DOI] 10.1016/j.annepidem.2022.03.002 PMC 바로가기 [Article Type] Article