Deciphering the genetic architecture and ethnographic distribution of IRD in three ethnic populations by whole genome sequence analysis전체 게놈 서열 분석에 의해 세 가지 민족 집단에서 IRD의 유전자 구조 및 민족 지학 분포를 해독합니다.Research Article Published on 2021-10-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition affected alteration American Analysis analyzed Atypical blood sample Blood samples causal variant Clinical diagnosis collected Combined complex consanguinity contributed contributing to disease pathology distribution dominant European examined Exome exome sequencing family member family members followed by GATK gene mutation gene mutations Genes genetic architecture genetic heterogeneity Genome genome analysis genome variant genome variants Genotype gnomAD hg19 identify Illumina individual initial linkage analysis mapped methodology minimum Mutation mutations ophthalmic pathology Patient pedigree phenotype PolyPhen2 Population populations proportion recruited reported responsible Retinal Degeneration sequence Sequencing Seven Spectrum Structural variant structural variants SVs The United States to define United States variant variants was performed WGS whole genome sequence whole-genome sequencing [DOI] 10.1371/journal.pgen.1009848 PMC 바로가기 [Article Type] Research Article
Machine learning to predict the source of campylobacteriosis using whole genome data전체 게놈 데이터를 사용하여 Campylobacteriosis의 공급원을 예측하는 기계 학습Research Article Published on 2021-10-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Accuracy Algorithm allelic Analysis approach Bacteria Bacterial Bacterial infections bacterium Bayesian inference Campylobacter jejuni Campylobacteriosis can be used cattle caused Classifier common disease complex core genome Disease surveillance DNA sequence DNA sequences drinking water effective interventions environmental reservoirs Epidemiology Evidence gastroenteritis Genes Genetic genetics Genome Human identify illnesses include infect infected individual infected individuals Infection infection source Intervention isolate isolates Lineage machine machine learning machine learning algorithm Machine learning algorithms occur Population genetics poultry predict provided Providing sequence sheep strain subset Transmission transmission potential Variation water WGS whole genome whole genome sequence [DOI] 10.1371/journal.pgen.1009436 PMC 바로가기 [Article Type] Research Article
Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity르완다에서 SARS-CoV-2의 게놈 시퀀싱은 혈통 다양성에서 들어오는 여행자의 중요성을 보여줍니다Article Published on 2021-09-292022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] A.23.1 airport analyzed B.1.1.7 B.1.351 B.1.351 variant circulating combating country COVID-19 COVID-19 transmission distribution Epidemiology Genetics research genomic genomic sequence Genomic surveillance highlight identify Infection International airport Lineage Local Metadata Phylogenomics Public health interventions reveal SARS-CoV-2 sequence Sequencing shift strain Strains Surveillance tested Transmission Transmission dynamics transmission rates Travel variant Viral whole genome sequence [DOI] 10.1038/s41467-021-25985-7 PMC 바로가기 [Article Type] Article
Molecular evolutionary characteristics of SARS‐CoV‐2 emerging in the United StatesResearch Article Published on 2021-09-202022-10-04 Journal: Journal of medical virology [Category] SARS, 변종, 진단, [키워드] addition Amino acid beta coronavirus bioinformatics Bioinformatics analysis calculate Characteristics coding decrease Evolution Genome Health highly pathogenic Hypothesis medium molecular molecular evolution Mutation nonsynonymous mutation nucleotide Positive selection RNA viruses S gene S protein SARS‐CoV‐2 SARS‐CoV‐2 sequence Seven Spike protein statistically significant Surveillance the United State The United States virus virus variants was used were used whole genome whole genome sequence [DOI] 10.1002/jmv.27331 PMC 바로가기 [Article Type] Research Article
Emergence and expansion of highly infectious spike protein D614G mutant SARS-CoV-2 in central India중부 인도에서 고발성 스파이크 단백질 D614G 돌연변이 체 SARS-COV-2의 출현 및 확장Article Published on 2021-09-132022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 치료기술, [키워드] A2a Analysis analyzed circulating clade COVID-19 development Economy emergence event Evolution Evolution of SARS-CoV-2 expansion followed by Genome genome sequence Genome sequence data global pandemic globe Health Increased index case index cases India information lockdown molecular evolution Mutant SARS-CoV-2 nanopore technology Oxford pandemic Phylogenetic analysis positive public health referred to research and development responsible SARS-CoV-2 SARS-CoV-2 strain Scientific community span spike protein D614G Spread subsequent Substitution Travel variant Viral protein Viral proteins virus whole genome sequence [DOI] 10.1038/s41598-021-95822-w PMC 바로가기 [Article Type] Article
Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 cladesSARS-CoV-2 프로테옴의 글로벌 변이와 5개의 지배적인 SARS-CoV-2 clades의 사전 잠금 출현 및 보급에 미치는 영향Article Published on 2021-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, [키워드] addition Analysis Antigen can be used clade clades Comparative analysis curated D614G Diagnosis dissemination dominant early stage facilitate Frequency gene sequence globe Highly recurring mutations independent independent of L37F lack Moderately recurring mutations Mutation Mutational susceptibility mutations N protein nsp10 Nsp12 NSP2 NSP6 occur Occurrence ORF3a ORF8 P323L pandemic performed persistence Phyloproteomics Propagation proteome proteome analysis Q57H SARS-CoV-2 SARS-CoV-2 proteome SARS-CoV-2 viromics. sequence T85I the SARS-CoV-2 Transmission Variation viral evolution whole genome sequence [DOI] 10.1016/j.meegid.2021.104973 PMC 바로가기 [Article Type] Article
Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences전체 게놈 서열에서 확인 된 감비아에서 수입 된 SARS-COV-2 균주의 기원Research Article Published on 2021-08-312022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] addition Analysis approach Asian baseline baseline data Contact contribute COVID-19 determine Economy European genomic genomic data global pandemic Health care Health care system health care systems index case index cases Infection information Local origin Phylogenetic analysis populations positive SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 disease SARS-CoV-2 strain SARS-CoV-2 virus sequenced Sequencing shown source of infection strain sub-Saharan Africa subsequent the SARS-CoV-2 virus Transmission Travel WGS while whole genome whole genome sequence Whole genome sequencing Wuhan Wuhan, China [DOI] 10.1371/journal.pone.0241942 PMC 바로가기 [Article Type] Research Article
G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19사하라 사막 이남 아프리카의 G6PD 분포 및 COVID-19에 대한 클로로퀸/하이드록시클로로퀸 기반 치료제 사용의 잠재적 위험Article Published on 2021-07-232022-09-10 Journal: The Pharmacogenomics Journal [Category] 변종, 유전자 메커니즘, 임상, 진단, [키워드] African allele frequency Analysis Chloroquine chloroquine/hydroxychloroquine clinical trial clinical trials continent country COVID-19 deficiency Deleterious distribution drug G6PD Genetics research Genotype Glucose Glucose-6-phosphate glucose-6-phosphate dehydrogenase Hydroxychloroquine individual nine potential risk Potential treatment potential treatments Predictive medicine Prevalence significant difference significant differences significant interaction South Africa sub-Saharan Africa Treatment treatments for COVID-19 variant variants Variation whole genome sequence [DOI] 10.1038/s41397-021-00242-8 PMC 바로가기 [Article Type] Article
High-precision and cost-efficient sequencing for real-time COVID-19 surveillance실시간 CovID-19 감시를위한 고정밀 및 비용 효율적인 시퀀싱Article Published on 2021-07-012022-09-01 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amplified clade coronavirus COVID-19 COVID-19 patients COVID-19 test deaths disease disease outbreaks full-length genome coverage genomic genomic RNA Genomic surveillance High-throughput sequencing individual Los Angele Los Angeles Molecular medicine Mutation nine Nsp12 ORF8 Outbreaks platform positive Precision produced public health reduced Sanger sequencing SARS-CoV-2 sequence sequenced Sequencing sequencing data significantly Surveillance swab specimen the SARS-CoV-2 Threats Transmission USA Viral viral infection Viral RNA whole genome whole genome sequence Whole genome sequencing [DOI] 10.1038/s41598-021-93145-4 PMC 바로가기 [Article Type] Article
Whole-genome analysis of Malawian Plasmodium falciparum isolates identifies possible targets of allele-specific immunity to clinical malariaMalawian Plasmodium falciparum 분리물의 전체 게놈 분석은 임상 말라리아에 대한 대립 유전자 특이적 면역의 가능한 표적을 식별합니다Research Article Published on 2021-05-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] acquired immunity acquisition allele Analysis Antigen antigens approach approaches characterized collected deaths develop disease expand Frequency genes encoding identify immune evasion immune responses Immunity immunologically individual infections investigated isolate longitudinal study malaria malaria parasite malaria parasites multiple allele multiple alleles naturally acquired immunity Plasmodium falciparum polymorphic site polymorphism Prevent Previous studies protective immune response Protein repeated repertoire representing response resulting sequence symptomatic individual symptomatic individuals Symptoms target targets thought Transmission understanding Vaccine vaccine candidate vaccine candidates variant whole genome sequence Whole-genome sequence [DOI] 10.1371/journal.pgen.1009576 PMC 바로가기 [Article Type] Research Article