Computational Saturation Mutagenesis of SARS-CoV-1 Spike Glycoprotein: Stability, Binding Affinity, and Comparison With SARS-CoV-2Molecular Biosciences Published on 2021-12-092022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] addition affinity Amino acid Analysis Antiviral binding binding affinity computational saturation mutagenesis decrease destabilized Effect enzyme example functions generate hACE2 host cell surface identify Interaction isolate Missense mutation Mutagenesis mutate Mutation mutations N-linked glycosylation predicted protein stability RBD receptor residue respiratory syndrome coronavirus RNA genome S glycoprotein S glycoproteins S protein SARS-CoV-1 SARS-CoV-2 saturation sequence similarity spike spike glycoprotein spike missense mutations stability the binding affinity the receptor-binding domain the S protein therapeutic Vaccine viral mutation weakened would increase [DOI] 10.3389/fmolb.2021.784303 PMC 바로가기 [Article Type] Molecular Biosciences
Determining What Changed Japanese Suicide Mortality in 2020 Using Governmental DatabaseArticle Published on 2021-11-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus age analysed average caused composed country COVID-19 COVID-19 pandemic decrease decreasing Deterioration determine Determining discrepancy disease drastic Factor Factors female females fluctuation Gender hazard Health household increase in Increasing indicated infection rate Japan Japanese linear Linear regression male males means mixed-effects model Mortality mortality rate motive National no decrease pandemic Patient Population populations predominant Region regions reported robust standard error Suicide suicide mortality was reduced without affecting would increase [DOI] 10.3390/jcm10215199 PMC 바로가기 [Article Type] Article
Modeling the impact of SARS-CoV-2 variants and vaccines on the spread of COVID-19Research article Published on 2021-11-012022-10-05 Journal: Communications in Nonlinear Science and Numerical Simulation [Category] 변종, [키워드] 501.V2 African Characteristics contagious coronavirus country COVID-19 vaccines develop disease Effect effective effective reproduction number evaluate Evolution example expected Follow-up Government greater Infection infections Italy knowledge Laboratory less main mechanism mathematical measure modeling mortality rates Mutation observé outcomes pandemic question reduce reported Reproduction number Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly South Spread spread of COVID-19 the disease the vaccine United Kingdom vaccination vaccination rate Vaccine Vaccines variant virus VOC 202012/01 would increase θθ-SIR Type model [DOI] 10.1016/j.cnsns.2021.105937 [Article Type] Research article
Additional Value of Non-contrast Chest CT in the Prediction of Adverse Cardiovascular Events in Patients With Novel Coronavirus Disease 2019 (COVID-19)Cardiovascular Medicine Published on 2021-10-152022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Adverse adverse cardiovascular events cardiac injury cardiovascular cardiovascular event Cardiovascular events Chest CT China Computed tomography Coronavirus disease 2019 COVID-19 COVID-19 patients Ct value CTR Diagnosis enrolled Follow-up hospitalized patient Injury laboratory-confirmed lesion Lung diseases males moderate multivariable analysis Myocardial negative correlation non-contrast chest CT novel novel coronavirus disease 2019 (COVID-19) occurred Patient patients predict prediction R 2 recorded Renmin Hospital Risk factors sensitivity specificity Spread troponin I two group university value were measured would increase Wuhan [DOI] 10.3389/fcvm.2021.738044 PMC 바로가기 [Article Type] Cardiovascular Medicine
New COVID-19 variant (B.1.1.7): Forecasting the occasion of virus and the related meteorological factors새로운 COVID-19 변종(B.1.1.7): 바이러스 발생 및 관련 기상 요인 예측Article Published on 2021-10-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 변종, 치료기술, [키워드] Analysis ARIMA association B.1.1.7 B.1.1.7 variant correlation country couple COVID-19 determine East Factor Forecast analysis Forecasting Health Organization Humidity incidence increase in Indonesia Meteorological factor Model moving average New New coronavirus reported South Spearman correlation analysis temperature variable variant virus virus spread West World Health Organization would increase [DOI] 10.1016/j.jiph.2021.05.019 PMC 바로가기 [Article Type] Article
“The effectiveness of rapid antigen test-based for SARS-CoV-2 detection in nursing homes in Valencia, Spain”"스페인 발렌시아 요양원에서 SARS-CoV-2 검출을 위한 신속한 항원 검사 기반의 효과"Article Published on 2021-10-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 치료기술, [키워드] analyzed Antigen benefit can be used collected Concordance conducted COVID-19 cut-off value diagnostic diagnostic test Effectiveness enrolled False negative false negative results group individual infected individuals Nasopharyngeal samples nasopharyngeal swabs Pandemics population groups positive positive RT-PCR Rapid Rapid techniques Rapid test returned RT-PCR RT-PCR testing SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 infected individual SARS-CoV-2 infected individuals SARS-COV-2 infection sensitivity Sensitivity and specificity Swab tested turnaround times Valencia Viral load was used would increase [DOI] 10.1016/j.jcv.2021.104941 PMC 바로가기 [Article Type] Article
Predictive symptoms for COVID-19 in the community: REACT-1 study of over 1 million people지역 사회에서 COVID-19에 대한 예측 증상 : 백만 명 이상의 REACT-1 연구Comparative Study Published on 2021-09-282022-09-10 Journal: PLoS Medicine [Category] SARS, 치료기술, [키워드] (alpha acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age approach asked assessment AUC B.1.1.7 B.1.1.7 lineage B.1.1.7 variant best carried chills collected Combination Community community transmission Contact tracing coronavirus cough country COVID-19 COVID-19 case COVID-19 infection Cycle threshold value detection rate determine eligibility Elliot England estimate Evidence Fever Genome sequencing groups identify IMPROVE individual Infection investigated involved Isolation Joshua limit limitation Lineage logistic regression model logistic regression models measure muscle aches N-gene National Health Service nose swab participant PCR positivity PCR test PCR testing PCR-positive performed persistent cough positive predict predicted Predictive Prevalence random Rapid recall bia repeated reported researcher respiratory response rates resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test selected Self-reported symptoms sense sense of smell sense of taste severe acute respiratory syndrome Coronavirus sore throat Spread subsampling Symptom symptomatic case symptomatic cases symptomatic individual symptomatic individuals Symptoms Taste test results tested these symptom these symptoms throat and nose swabs Transmission Univariate analysis Viral genome sequencing Volunteer Weighting wild type wild-type virus would increase [DOI] 10.1371/journal.pmed.1003777 PMC 바로가기 [Article Type] Comparative Study
Loneliness among Middle-Aged and Older Middle-Aged Adults in Russia (Saint Petersburg) before and during COVID-19 PandemicArticle Published on 2021-09-202022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, SARS, [키워드] activated activities adjust adulthood age Analysis caused change changes in Characteristics collected complex conducted COVID-19 COVID-19 pandemic demographic data domains Effect Emotional loneliness environmental factors expected groups increase in inventory Isolation loneliness males mechanism Modification Older pandemic participant physical positive loneliness predicted Regression reported Russia Saint Petersburg scale solitude would increase [DOI] 10.3390/ijerph18189889 PMC 바로가기 [Article Type] Article
The impact of social distancing, contact tracing, and case isolation interventions to suppress the COVID-19 epidemic: A modeling studyCOVID-19 전염병을 억제하기 위한 사회적 거리두기, 접촉 추적 및 사례 격리 개입의 영향: 모델링 연구Article Published on 2021-09-012022-09-11 Journal: Epidemics [Category] SARS, 치료기술, [키워드] 95 % CI Case isolation China compartmental model confirmed COVID-19 case Contact Contact tracing Continuous country COVID-19 dependent on detect Effectiveness Epidemic First wave FIVE had no independent information Intervention Medicine Medicines mitigate modeling MOST nonpharmaceutical intervention Nonpharmaceutical interventions outbreak performed Public health intervention Research Result second wave Simulation social distancing Spread suppress symptomatic case Travel Vaccine with COVID-19 would increase Zhejiang [DOI] 10.1016/j.epidem.2021.100483 PMC 바로가기 [Article Type] Article
High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial주로 인간 면역 결핍 바이러스 (HIV)-양성 우간다 성인에서 결핵성 수막염의 치료를위한 고용량 경구 및 정맥 내 리팜피신 : 2 상 공개 라벨 무작위 대조 시험Major Articles and Commentaries Published on 2021-09-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] 95% confidence interval Administered Adults Adverse adverse events AUC C max CD4 cerebrospinal fluid Concentration Controlled CSF current dose enrolled event geometric geometric mean High-dose HIV Human Human immunodeficiency virus immunodeficiency virus IMPROVE inhibitory concentration intensified therapy International interquartile range intravenous intravenously majority median Meningitis minimal inhibitory concentration not differ occurred Open-label open-label trial oral outcome participant Participants Patient patients performed pharmacokinetic phase PK data plasma Primary outcome Primary outcomes Randomized regimen Result rifampicin Safe serum Standard of care Standard-of-care sustained TBM therapeutic Toxicity Trial Tuberculosis tuberculous tuberculous meningitis undetectable with HIV would increase [DOI] 10.1093/cid/ciab162 PMC 바로가기 [Article Type] Major Articles and Commentaries