Association of administration of IFN-α with mortality among patients hospitalized with coronavirus disease 2019Research Article Published on 2021-03-032022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] administration all-cause mortality alleviate Analysis Clinical characteristics clinical evidence coronavirus disease COVID-19 Cox regression model Critical death decrease demonstrated determine disease severity hazard ratio hospitalized COVID-19 patient IFN-α interferon Kaplan–Meier logistics logistics analysis Mortality occurred Odds ratio offered patients patients hospitalized patients treated patients with COVID-19 propensity score matching recent Result Retrospective study SARS-CoV-2 Support survival survival curve treat treated [DOI] 10.2217/fvl-2020-0404 PMC 바로가기 [Article Type] Research Article
High-Throughput Wastewater SARS-CoV-2 Detection Enables Forecasting of Community Infection Dynamics in San Diego CountyObservation Published on 2021-03-022022-10-29 Journal: mSystems [Category] COVID-19, [키워드] Accuracy acute respiratory syndrome alleviate approach ARIMA assessment Asymptomatic automated average Clinical symptoms clinically Community comparison Concentration coronavirus coronavirus disease correlated strongly COVID-19 detect detection Diego Dynamics Efficiency Epidemics Epidemiology estimate estimates faster Forecasting Infection information outbreak predict Prevalence prevalence rate processed protocol reducing reported robust SARS-CoV-2 scaled up sensitivity shown Surveillance Treatment Viral detection viral genome virus Volume wastewater [DOI] 10.1128/mSystems.00045-21 PMC 바로가기 [Article Type] Observation
Investigation of immune cells on elimination of pulmonary-Infected COVID-19 and important role of innate immunity, phagocytes폐감염 COVID-19 제거에 대한 면역세포의 연구와 선천면역, 식세포의 중요한 역할Review Published on 2021-03-012022-09-12 Journal: Reviews in Medical Virology [Category] 진단, [키워드] Activation acute phase Adaptive immune response Adults alleviate antibody B cell cause CD4+ T cell CD4+ T cells children contribute COVID-19 COVID-19 infection Factor IgM and IgG Immune cell immune system Infection innate immune system Innate immunity investigation Mild much higher observation Patient patients phagocyte producing PROTECT required vaccination vaccine for COVID-19 white [DOI] 10.1002/rmv.2158 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Causes a Different Cytokine Response Compared to Other Cytokine Storm-Causing Respiratory Viruses in Severely Ill PatientsImmunology Published on 2021-03-012022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activate adaptive alleviate analyzed cause caused collected conserved contributing to coronavirus Coronavirus 2019 COVID-19 COVID-19 cases CRS cytokine cytokine level Cytokine release syndrome cytokine response Cytokine storm different disease downstream dysregulation evaluate exacerbated Factor H5N1 H7N9 help highlight identify IFN IL-10 IL-2 IL-4 IL-5 Ill Immune cell indicate induce Infection Inflammation Influenza influenza A interferon Intervention literature analysis MERS- and SARS-CoV MERS-CoV Mortality occur Other other coronavirus outbreak Patient patient data prevalent pro-inflammatory cytokines producing respiratory respiratory viruses response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic subgroup of patients systematic review the SARS-CoV-2 unique viral pathogen virus viruses [DOI] 10.3389/fimmu.2021.629193 PMC 바로가기 [Article Type] Immunology
Success of prophylactic antiviral therapy for SARS-CoV-2: Predicted critical efficacies and impact of different drug-specific mechanisms of actionSARS-CoV-2에 대한 예방적 항바이러스 요법의 성공: 다양한 약물 특이적 작용 기전의 예측된 임계 효능 및 영향Research Article Published on 2021-03-012022-09-10 Journal: PLoS Computational Biology [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] Administering alleviate antibody Antiviral antiviral activity antiviral drug antiviral drugs antiviral therapy can not Cell Combination combination therapy Critical Defense detectable drug drug efficacies Drug efficacy early phase Efficacy evaluate feasible Health care Health care worker health care workers Healthcare systems high risk infected cells Infection Infectious virus initial less mechanism medication monoclonal antibodies pandemic Particles predict Prevent prevented Prophylactic prophylactic treatment prophylactically Prophylaxis reduce reduced reducing Repurposed drugs risk risk of infection Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 spike protein small molecule Spike protein suppressed symptom severity tested the SARS-CoV-2 therapy Transmission Treatment Viral viral clearance viral entry viral infection viral infections viral inoculum viral loads virus infection [DOI] 10.1371/journal.pcbi.1008752 PMC 바로가기 [Article Type] Research Article
Acceptability of a COVID-19 Vaccine Among Healthcare Workers in the Kingdom of Saudi ArabiaMedicine Published on 2021-03-012022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acceptability affecting alleviate being calculated conducted country COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional survey determine Factor Frequency healthcare worker Healthcare workers Hesitancy high risk identify Infection Intention Kingdom logistic regression model male multivariable Probability questionnaire Regression analyses Risk perception Saudi Arabia Sociodemographic characteristics Study participants the vaccine used data vaccinate Vaccine variables was used worker [DOI] 10.3389/fmed.2021.644300 PMC 바로가기 [Article Type] Medicine
Administration of zoledronic acid alleviates osteoporosis in HIV patients by suppressing osteoclastogenesis via regulating RANKL expressionzoledronic acid 투여는 RANKL 발현 조절을 통해 파골세포 형성을 억제함으로써 HIV 환자의 골다공증 완화Research Article Published on 2021-02-262022-09-06 Journal: Molecular Medicine [Category] Communicable Disease, [키워드] 3′ UTR activated activating administration alleviate binding carried demonstrated down-regulated ELISA evaluate expression expression of gene HIV HIV patient HIV patients inhibitory effect Inhibitory effects involved JNK luciferase Luciferase assays mechanism miR-101 miR-145 miRNA modulating osteocalcin osteoclast Osteoclastogenesis Osteoporosis Pathways patients PRKACB quantitative real-time PCR RANKL Real-time PCR restored Result serum signaling pathway signaling pathways significantly Smad3 subject suppressed tenofovir treated Treatment was performed was used western blot Zoledronic acid [DOI] 10.1186/s10020-021-00276-5 PMC 바로가기 [Article Type] Research Article
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19Article Published on 2021-02-242022-10-04 Journal: Nature Communications [Category] MERS, 유전자 메커니즘, 진단, 치료기술, [키워드] a metric alleviate Analysis animal animal model cause convalescent COVID-19 COVID-19 disease COVID-19 pandemic cynomolgus macaque cynomolgus macaques Efficacy emerging disease Endpoint Evidence form Infection Intervention Lower respiratory tract Lung histopathology majority Mild milder infection moderate Non-human non-human primates Novel coronavirus Pathogenesis patients pulmonary lesion replicate reported respiratory sample responses against rhesus SARS-CoV-2 SARS-COV-2 infection scoring system transcriptional Translational research used to evaluate Vaccine viral infection [DOI] 10.1038/s41467-021-21389-9 PMC 바로가기 [Article Type] Article
Changes in Drug Use Patterns during the COVID-19 Pandemic in Italy: Monitoring a Vulnerable Group by Hair Analysis이탈리아 COVID-19 팬데믹 기간 동안 약물 사용 패턴의 변화: 모발 분석으로 취약 그룹 모니터링Article Published on 2021-02-182022-09-12 Journal: International Journal of Environmental Research an [Category] MERS, 진단, [키워드] abstinence Addiction Affect affected alcohol alcohol consumption alleviate Analysis Benzodiazepine benzodiazepines cannabis change cocaine Complete Consumption countermeasure COVID-19 COVID-19 pandemic disorder drug Effect First wave group hair hair analysis heroin high-risk population Isolation Italy laboratory data lockdown MDMA measure monitoring number of sample number of samples opposite pattern Population positive produced remained Self-medication shift significant changes in subject substance abuse disorder [DOI] 10.3390/ijerph18041967 PMC 바로가기 [Article Type] Article
Targeting the Complement Serine Protease MASP-2 as a Therapeutic Strategy for Coronavirus InfectionsArticle Published on 2021-02-172022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] Activation alleviate blocking candidate catalytic activity caused complement conducted Consequences conserved contribute Coronaviral coronavirus Coronavirus infections Coronaviruses drug Drug repurposing enzyme human coronavirus Hyperactivation in silico in vitro in vivo Infection inhibitor inhibitory activity Interaction lectin pathway lung Lung injury MASP-2 MERS-CoV Molecular modelling monoclonal antibody N proteins nucleocapsid patients Prevent Protein protein-protein interaction Proteins reduce mortality rate SARS-CoV SARS-CoV-2 screened selected serine protease severe complication Strategy Support targeting tested Treatment triggered [DOI] 10.3390/v13020312 PMC 바로가기 [Article Type] Article