Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptorIpomoeassin-F는 SARS-CoV-2 스파이크 단백질과 숙주 세포막 수용체의 시험관 내 생합성을 억제합니다125 Published on 2021-02-152022-09-10 Journal: Journal of Cell Science [Category] MERS, 치료제, [키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents assembly biogenesis biosynthetic block causative agent Cell-free translation component COVID-19 Endoplasmic reticulum envelope enzyme ER membrane ER membrane complex highlight highlighting Host host cell host cell membrane human cell in vitro inhibit inhibitor insertion mechanisms membrane protein Membrane proteins ORF8 protein ORF8 proteins paper pathogenic pathogenicity Pathogens Person plasma membrane Protein Protein target receptor reducing respiratory Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Sec61 Sec61 translocon small molecule Spike protein structural proteins synthesised the SARS-CoV-2 therapeutic translocation Viral Viral particles viral pathogens Viral protein biogenesis viral spike viruses [DOI] 10.1242/jcs.257758 PMC 바로가기 [Article Type] 125
Characteristics and Outcome of SARS-CoV-2 Infection in Cancer Patients암 환자에서 SARS-CoV-2 감염의 특성 및 결과Article Published on 2021-02-062022-09-10 Journal: JNCI Cancer Spectrum [Category] MERS, 치료제, [키워드] accounted active cancer Administered Admission Advanced cancer Analysis Antibiotics antiviral agent Antiviral agents blood count Breast cancer C-reactive protein Cancer Cancer center cancer patient Cancer patients case mix Chain Reaction Characteristics Computerized tomography concern coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 incidence COVID-19 pandemic COVID-19 pneumonia COVID-19–related symptoms cured Curie death diagnosed with COVID-19 Diagnosis died driven by followed by General population hematological higher risk initial intensive care laboratory abnormalities lung lung parenchyma malignancies outcome Patient patients patients treated Pneumonia polymerase chain polymerase chain reaction Prognostic factor Result reverse transcription SARS-CoV-2 Severity of infection therapy Tumor Variation [DOI] 10.1093/jncics/pkaa090 PMC 바로가기 [Article Type] Article
A rapid review of recent advances in diagnosis, treatment and vaccination for COVID-19Review Published on 2021-02-012022-10-27 Journal: AIMS Public Health [Category] COVID-19, [키워드] Antibiotics antigen test Antiviral agents approaches BCG caused China conducted convalescent plasma coronavirus Corticosteroids COVID-19 database detect Diagnosis diagnostic drug early treatment effective Genome Google Scholar introduced Isolation non-specific pandemic Patient Research resulting reverse transcription polymerase chain reaction SARS-CoV-2 Spread Symptom therapeutic options therapy Treatment vaccination Vaccine Web of Science Wuhan [DOI] 10.3934/publichealth.2021011 PMC 바로가기 [Article Type] Review
Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach체계적인 가상 스크리닝 접근법을 통한 COVID-19 치료를 위한 잠재적인 Mpro 억제제 식별Article Published on 2021-02-012022-09-11 Journal: Molecular diversity [Category] SARS, 신약개발, 치료기술, 치료제, [키워드] acute respiratory syndrome amides antiviral agent Antiviral agents approach approved Asinex BioDesign carried caused China clinically Compound conformational Corona virus coronavirus COVID-19 creating derivatives diagnostic drug drug library exhibiting FDA genomic RNA globe identification inhibitor inhibitors Interaction iodixanol iotrolan lead limitations Modification MPro nelfinavir non-structural protein non-structural proteins Novel coronavirus pathogen pharmacophore polyprotein polyproteins pralmorelin Precision predicted produced protease pyrazoles PYRROLIDINE respiratory Respiratory complications Ritonavir saquinavir SARS-CoV-2 Screening screenings Severe acute respiratory syndrome Spread target protein therapeutic agent therapeutic agents translation Treatment Virtual screening virus Virus Disease worldwide pandemic [DOI] 10.1007/s11030-020-10130-1 PMC 바로가기 [Article Type] Article
Potential anti-COVID-19 activity of Egyptian propolis using computational modelingShort Communication Published on 2021-02-012022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] addition Analysis Anti-COVID-19 Antiviral agents binding characterized collected computational modeling COVID-19 enzyme geographical area Lopinavir macromolecule material pandemic Potential predict Propolis protease Remdesivir Result RNA-dependent RNA polymerase spike protein S1 umifenovir [DOI] 10.2217/fvl-2020-0329 PMC 바로가기 [Article Type] Short Communication
Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: Insights into biological activity and mechanism of actionArticle Published on 2021-02-012023-06-23 Journal: FASEB journal : official publication of the Federa [Category] 신종인플루엔자, [키워드] antimicrobial peptides Antiviral agents Influenza parainfluenza viral infection [DOI] 10.1096/fj.202001885RR
Research Progress on the Cardiac Injury from ACE2 Targeting in SARS-CoV-2 InfectionSARS-CoV-2 감염에서 ACE2 표적화로 인한 심장 손상에 대한 연구 진행Review Published on 2021-01-302022-09-10 Journal: Biomolecules [Category] MERS, 유전자 메커니즘, 치료기술, 치료제, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral agent Antiviral agents cardiac cardiac injury cause Characteristics clinician country COVID-19 Epidemic Health help implementation Infection Injury manifestation measure mechanism Novel coronavirus organ Pathogenesis populations present Prevent Progress pulmonary injury SARS-CoV-2 SARS-COV-2 infection spike Symptom target organs targeting therapeutic therapy transmission of SARS-CoV-2 Vaccine Viral viral invasion virus [DOI] 10.3390/biom11020196 PMC 바로가기 [Article Type] Review
Antiviral activity of bioactive phytocompounds against coronavirus: An updateArticle Published on 2021-01-232022-11-01 Journal: Journal of virological methods [Category] COVID-19, MERS, [키워드] Abstract Antiviral Antiviral agents caused Coronaviruses COVID-19, mechanism disease drug effective Evidence experimental evidence Health humans increase in Infection lack limitation MERS-CoV Migration outbreak Phytocompounds plant plant compound plants raised required Research researcher rising SARS-CoV SARS-CoV-2 Side effect therapeutic use Treatment Virus Disease [DOI] 10.1016/j.jviromet.2021.114070 PMC 바로가기 [Article Type] Article
Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent오프 타겟 시험관 내 프로파일링은 렘데시비르가 고도로 선택적인 항바이러스제임을 보여줍니다Article Published on 2021-01-202022-09-11 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] 50% effective concentration addition adenosine aerobic agent Anti-SARS-CoV-2 Activity Antiviral Antiviral agents assays biochemical biochemical assay cells cellular cellular respiration Concentration coronavirus COVID-19 cytotoxicity demonstrated DNA DNA and RNA Effect elicit epithelial cells evaluated Filovirus filoviruses GS-5734 human airway human airway epithelial human airway epithelial cells human cell human cell line human cell lines human cells inhibitor Interaction Last MERS MERS-CoV metabolic conditions metabolite Mitochondria mitochondrial mitochondrial DNA mitochondrial respiration nucleoside nucleoside analogs oxygen polymerases primary cells Profiling protein synthesis ranged RDV reactive oxygen species Remdesivir reported resulting safety profile SARS-CoV SARS-CoV-2 selective selectivity indices target tested Toxicity Treatment triphosphate turn Viral Viral RNA [DOI] 10.1128/AAC.02237-20 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino oligomers펩타이드 결합 모르폴리노 올리고머에 의한 Vero 세포 배양에서 SARS-CoV-2 억제Article Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] 치료제, [키워드] antiviral agent Antiviral agents base-pair candidate Candidates causative agent Cell Cell culture cell cultures cell viability composed Compound COVID-19 Culture development direct-acting evaluated experiment genomic RNA global public health growth infectivity assay inhibition inhibitory effect negative control non-toxic oligomer pathogen peptide Post-infection Quantitative Quantitative RT-PCR random reduce expression reducing Replication replication of SARS-CoV-2 RNA RT-PCR SARS-CoV-2 sequence sequences steric suppress TCID50 the SARS-CoV-2 titre transcription regulatory sequence Treatment uninfected cell uninfected cells Vero Cell VERO-E6 viability Viral viral growth virus was measured [DOI] 10.1093/jac/dkaa460 PMC 바로가기 [Article Type] Article