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[키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected airway airways Allergic asthma Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral Asthma asthmatic cause caused Cell Cell culture cell cultures cell tropism cells ciliated cell ciliated cells coronavirus COVID-19 COVID-19 severity down-regulated gene down-regulated genes electron microscopy enzyme epithelial epithelial cells examined expression gene expression analyses Gene Expression Omnibus Genes glycoprotein HAE high risk host–virus interaction human airway human airway epithelial human airway epithelial cells IL-13 IL-13 cytokine immunohistochemistry In situ hybridization infected cells Infection interferon interleukin interleukin-13 Intracellular involved keratan sulfate Lung disease mechanism Messenger RNA Microscopy MUC5AC mucin Mucus number of infected primary human airway reduced removal Replication RNA RNA-sequencing SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shedding shielding significantly Spread sulfate susceptibility Transmission Transport TRAP treated up-regulated viral egress viral entry Viral load Viral reservoir viral spread viral titers virions viruses were infected
[DOI] 10.1073/pnas.2119680119 PMC 바로가기 [Article Type] Article