Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 ExacerbationsReview Published on 2020-08-242022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] acute lung injury acute respiratory distress addition age ALI Apoptosis ARDS augmentation autophagic autophagy catabolic cellular debris cellular homeostasis cellular senescence CF CFTR chronic obstructive clearance contribute COPD coronavirus COVID-19 dysfunction effective exacerbate Exacerbation exacerbations Factors fibrosis Genetic immune response impairment involved IPF Lung disease Lung diseases mechanisms microbial misfolded protein Pathogenesis pathway progression Protein pulmonary disease pulmonary fibrosis recent respiratory response Restrictive lung disease resulting SARS-CoV2 syndrome therapeutic potential transmembrane [DOI] 10.3390/cells9091952 PMC 바로가기 [Article Type] Review
Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial만성 폐쇄성 폐질환의 근육량 개선을 위한 강화 유청 음료: 단일 맹검, 무작위 임상 시험Research Published on 2020-08-172022-09-06 Journal: Respiratory Research [Category] Communicable Disease, [키워드] analyzed Bioelectrical Impedance Analysis Body body composition body protein Cachexia calculated change changes in chronic obstructive Concentration concentrations conducted control group COPD Cytokines Effect effective Efficacy fat-free mass fortified glutathione handgrip strength IL-6 Inflammation Inflammatory cytokine Inflammatory cytokines interleukin Intervention intervention group life Lung diseases Magnesium Malnutrition malondialdehyde muscle mass Muscle strength Necrosis nutritional intervention nutritional supports obstructive pulmonary diseases participant Patient Primary outcome Primary outcomes progression pulmonary disease Quality of life randomized clinical trial randomized trial Result secondary outcome Secondary outcomes serum serum concentrations significant changes in significant decrease significantly single-blind Skeletal muscle suggested Support TNFα Tumor tumor necrosis tumor necrosis factor two groups variables Vitamin Vitamin C was performed were measured whey [DOI] 10.1186/s12931-020-01466-1 PMC 바로가기 [Article Type] Research
Tiotropium Is Predicted to Be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway AnalysisArticle Published on 2020-07-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome addition Affect Airway inflammation Antiviral approaches bioinformatics caused Cell chronic obstructive complex Comprehensive COPD coronavirus coronavirus disease COVID-19 COVID-19 patients deregulated drug effective enrichment analyses epithelial expression Genes IL1B IL6 IL8 IMPROVE in vitro in vivo indicated Infection inhibit Interaction Lung fibrosis molecular molecular pathways negative regulation NFkB1 NFKB2 NHBE Ontology outbreak pathologic feature pathway Pathways Patient patients predicted pulmonary disease Pulmonary function Rapamycin reduced RELA RelB Remdesivir Replication rheumatoid arthritis RNA-Seq RNA-seq data SARS-CoV-2 shown significantly the SARS-CoV-2 therapeutic intervention tiotropium TNF upregulated upregulation [DOI] 10.3390/v12070776 PMC 바로가기 [Article Type] Article
Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysisResearch Paper Published on 2020-07-152022-10-28 Journal: Aging (Albany NY) [Category] COVID-19, SARS, [키워드] 2019-nCoV abnormality acute respiratory distress Admission age ARDS association Cerebrovascular disease chronic chronic obstructive Comorbidity composite endpoint conducted contributed COPD Coronary heart disease coronavirus disease COVID-19 COVID-19 case criteria death Disease progression disease severity eligible endpoints epidemiological evaluate Evidence Factor Gender ICU intensive care invasive ventilation item Kidney disease male Meta-analysis nine Older age prognostic pulmonary disease quantitative synthesis Reporting review SARS-CoV-2 severity severity and prognosis significantly significantly higher syndrome systematic review the disease [DOI] 10.18632/aging.103579 PMC 바로가기 [Article Type] Research Paper
Multi-organ Dysfunction in Patients with COVID-19: A Systematic Review and Meta-analysisReview Published on 2020-07-132022-10-28 Journal: Aging and Disease [Category] COVID-19, [키워드] 95% CI 95% confidence interval Acute cardiac injury acute cerebrovascular disease Acute kidney injury acute multiorgan injury acute respiratory distress aggravate alanine aminotransferase ALT Analysis article Aspartate aminotransferase association AST cardiac troponin cardiovascular disease Cerebrovascular disease Chronic kidney disease chronic liver disease chronic obstructive CKD CLD clinical feature clinically conditions COPD COVID-19 COVID-19 patients creatinine CVD database develop disease Effect evaluated Evidence functions hypertension incidence Increased investigator lactate dehydrogenase LDH Meta-analysis Mortality Multiorgan dysfunction multiorgan injury Myoglobin Odds ratio organ organ dysfunction parameter Patient patients pulmonary disease review searched selected severe COVID-19 susceptible syndrome total bilirubin trials urea was performed [DOI] 10.14336/AD.2020.0520 PMC 바로가기 [Article Type] Review
Identifying Patients at Greatest Risk of Mortality due to COVID-19: A New England PerspectiveEndemic Infections Published on 2020-07-082022-10-28 Journal: Western Journal of Emergency Medicine [Category] COVID-19, SARS, [키워드] 95% CI 95% confidence interval acute respiratory syndrome age Analysis being can be used Care chronic obstructive Comorbidities confirmed case Connecticut COPD coronavirus COVID-19 patient deaths Deceased diabete died discharged distribution England examined Factor frontline healthcare worker Generalized linear model HCW Health hospital Hospitalized hospitalized COVID-19 patients identify identifying in-hospital mortality likelihood log Massachusett Mortality New Older outcome pandemic Patient physical PROTECT protective effect public health pulmonary disease reducing Result resulting retrospective cohort study risk risk factor SARS-CoV-2 severe disease specificity Spread Trinity was increased [DOI] 10.5811/westjem.2020.6.47957 PMC 바로가기 [Article Type] Endemic Infections
Risk factors for the exacerbation of patients with 2019 Novel Coronavirus: A meta-analysisResearch Paper Published on 2020-07-062022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019-nCoV Acute cardiac injury Acute kidney injury acute respiratory distress addition ARDS cardiovascular disease chronic liver disease cohort study Complication COPD cough diabetes diarrhoea Dyspnea exacerbation prediction Factor fatigue Fever Gender Google headache hypertension ICU IMPROVE intensive care malignancy Meta-analysis myalgia non-ICU novel occur Patient patients Pneumonia Probability reported risk risk factor Seafood searched Shock significantly syndrome the patient Treatment two groups [DOI] 10.7150/ijms.47052 PMC 바로가기 [Article Type] Research Paper
Point-of-Care Chest Ultrasonography as a Diagnostic Resource for COVID-19 Outbreak in Nursing HomesShort communication Published on 2020-07-012022-10-05 Journal: Journal of the American Medical Directors Associat [Category] 진단, [키워드] age approach Chest Clinical data consolidation consolidations COPD coronavirus Coronavirus disease-19 COVID-19 COVID-19 outbreak diagnosed Diagnosis diagnostic distribution Dyspnea evaluate feasibility feasible Fever home hospital Hospitalization information interstitial pneumonia Italy Long-term care Lung Ultrasonography management Mild moderate Nursing objective Older participant Participants Patient patients Pneumonia Presence presenting required respiratory diseases respiratory symptom Result setting subpleural tested therapeutic Thoracic Ultrasonography Viral pneumonia was performed [DOI] 10.1016/j.jamda.2020.05.050 [Article Type] Short communication
Predictors of severe or lethal COVID-19, including Angiotensin Converting Enzyme inhibitors and Angiotensin II Receptor Blockers, in a sample of infected Italian citizens감염된 이탈리아 시민의 표본에서 안지오텐신 전환 효소 억제제 및 안지오텐신 II 수용체 차단제를 포함한 심각하거나 치명적인 COVID-19의 예측자Research Article Published on 2020-06-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] ACEi age Analysis angiotensin Angiotensin II angiotensin-converting enzyme inhibitors AOR ARB ARBs association blocker Cancer cardiovascular disease cardiovascular diseases case-control study clinical charts COPD COVID-19 COVID-19 severity CVD Deceased diabete diabetes disease disease severity Electronic health records Enzyme inhibitor Gender hypertension hypertensive independent predictor Infection Italian lethal disease male median medication Mild Multivariate analysis Older age Patient Physicians predicted predictor proportion Receptor Blockers renal retrospective SARS-COV-2 infection severe disease severe symptoms Significant subject therapy treated Treatment [DOI] 10.1371/journal.pone.0235248 PMC 바로가기 [Article Type] Research Article
Clinical and CT findings of COVID-19: differences among three age groupsResearch Article Published on 2020-06-222022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] affected age analyzed Characteristics Chest chronic obstructive clinical clinical manifestations COPD coronavirus disease COVID-19 CRP CT finding CT findings diabete Diabetes Mellitus diagnosis of COVID-19 epidemiological feature group groups hypertension involved Laboratory lesion lobe Lymphocytes Monocytes neutrophil Novel coronavirus occurred patients patients with COVID-19 Pneumonia pulmonary disease Pulmonary infection Result significant difference Spread stratified subpleural three group three groups X-ray computed tomography [DOI] 10.1186/s12879-020-05154-9 PMC 바로가기 [Article Type] Research Article