Performance of two rapid point of care SARS-COV-2 antibody assays against laboratory-based automated chemiluminescent immunoassays for SARS-COV-2 IG-G, IG-M and total antibodiesArticle Published on 2021-01-192022-10-29 Journal: Practical Laboratory Medicine [Category] COVID-19, [키워드] 95% CI Abbott analysed antibodies antibody assay Antibody assays Antigen Architect Assay evaluation automated chemiluminescent immunoassay CLIA Concordance condition Control COVID-19 cross-reactivity dsDNA evaluated IgG IgM IMPROVE information Like NPV PanBio performance POCT point of care point-of-care test point-of-care testing POS positive positive RT-PCR PPV Predictive Prevalence Rapid recruited Result Roche RT-PCR SARS-CoV-2 SARS-CoV-2 antibody sensitivity sera specificity subject total antibody utility Viral hepatitis were assessed were used [DOI] 10.1016/j.plabm.2021.e00201 PMC 바로가기 [Article Type] Article
Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune DiseasesSARS-CoV-2 단백질에 대한 인간 단일클론 항체와 조직 항원의 반응: 자가면역 질환에 대한 시사점Immunology Published on 2021-01-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] (spike protein Actin anti-SARS-CoV-2 antibodies antibody Antigen applied approved Autoimmune diseases Autoimmunity BLAST COVID-19 cross-reactivity determine disease disorder Diversity envelope protein epitope epitope mapping exacerbate F-actin Gastrointestinal group homology Human human monoclonal antibodies Human monoclonal antibody human tissue human tissues immune immune reactivity membrane protein Mitochondria molecular molecular mimicry monoclonal nucleoprotein occur patients with COVID-19 polyclonal potential risk Protein Proteins reaction Reactions reactivity representing Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 protein SARS-CoV-2 proteins selective severity similarities similarity Spike protein subgroups subject susceptible the disease Thyroid tissue tissue antigen tissue antigens tissues TPO Treatment Vaccine Viral protein Viral proteins virus with COVID-19 [DOI] 10.3389/fimmu.2020.617089 PMC 바로가기 [Article Type] Immunology
Nucleoprotein-based ELISA for detection of SARS-COV-2 IgG antibodies: Could an old assay be suitable for serodiagnosis of the new coronavirus?Article Published on 2021-01-132022-10-04 Journal: Journal of virological methods [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] Adenovirus anti-nucleoprotein antibody Antibody detection Aspergillus fumigatus Bacterial Concordance confidence interval confirmed case coronavirus COVID-19 cross-reactivity diagnosed ELISA ELISA kit ELISA kits enzyme-linked immunosorbent evaluated Fungal infection healthy controls IgG IgG antibody individual Infection infections Influenza virus Klebsiella pneumoniae majority male Mycobacterium tuberculosis Nucleoprotein antigen objective other respiratory virus Pneumonia Protein protocol reactivity respiratory syncytial virus Result rhinovirus SARS-CoV-2 SARS-CoV-2 nucleoprotein SARS-CoV2 sensitivity sera serum IgG serum sample specificity Staphylococcus Streptococcus pneumoniae subject symptom onset virus was determined [DOI] 10.1016/j.jviromet.2021.114064 PMC 바로가기 [Article Type] Article
Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19Research Article Published on 2021-01-122022-10-28 Journal: BMC Medicine [Category] COVID-19, MERS, [키워드] age arising calibrated Care country COVID-19 COVID-19 hospitalisation COVID-19 severity cross-protection cross-reactivity data interpretation diminishe disease severity effort Endemic coronaviruses endemic human coronavirus epidemiological explain groups Health highlight hospitalisation hypothesise immunopathology increase Individual-based model Infection Infectious disease dynamics knowledge mathematical mathematical model mechanism Potential provide Research Result risk SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 transmission severe SARS-CoV-2 severity of COVID-19 supplementary material Variation [DOI] 10.1186/s12916-020-01887-1 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Epitope Mapping on Microarrays Highlights Strong Immune-Response to N Protein RegionArticle Published on 2021-01-112022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] click chemistry Cohort collected common cold coronavirus COVID-19 cross-reactivity diagnostic epitope epitope mapping healthy individuals high-density IgG IgM immunodominant immunoreactivity implementation independent mapping Microarray N protein nucleocapsid peptide peptide microarray peptide microarrays polyprotein positive probe Protein reached Region reported SARS-CoV-2 SARS-CoV-2 spike sensitivity sera serological serological test serum sample specificity Strong symptoms onset tested the N protein [DOI] 10.3390/vaccines9010035 PMC 바로가기 [Article Type] Article
Performance Characteristics of the Vidas SARS-CoV-2 IgM and IgG Serological AssaysVidas SARS-CoV-2 IgM 및 IgG 혈청학적 분석의 성능 특성Immunoassays Published on 2021-01-082022-09-10 Journal: Journal of Clinical Microbiology [Category] Coronavirus, SARS, 진단, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 assays automated caused clinical clinical sensitivity clinical specificity coefficients Combined coronavirus COVID-19 COVID-19 pandemic cross-reactivity declined Diagnosis Emergency use authorization epidemiological epidemiological surveillance healthy donor Hospitalized IgG IgG responses IgM and IgG IgM/IgG immunoserology Infection pandemic Patient patients performance positive Precision reached remained respiratory respiratory virus response reverse transcriptase reverse transcriptase PCR RT-PCR SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgM SARS-CoV-2 infections SARS-CoV-2 patients SARS-CoV-2 PCR SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody sensitivity sera Seroconversion Serological assay serological assays serological test Serological testing Serological tests significantly higher specific IgM specificity Spread Surveillance symptom onset test results Variation Vidas virus infection was determined [DOI] 10.1128/JCM.02292-20 PMC 바로가기 [Article Type] Immunoassays
An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targetsDatabase Published on 2021-01-072022-10-31 Journal: Genome Medicine [Category] COVID-19, [키워드] activity Analysis appear COVID COVID-19 cross-reactivity D614G diagnostic epitope Epitopes Human-coronavirus Immuno-informatics in silico Mutation Nsp12 nucleocapsid protein platform Post-vaccine Protein provide resource SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 spike sequence serological serological tool serology spike Surveillance target targets Vaccine [DOI] 10.1186/s13073-020-00822-6 PMC 바로가기 [Article Type] Database
Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T-cell memory formation after mild COVID-19 infection경도 높은 처리량 TCR 레퍼토리 프로파일링은 가벼운 COVID-19 감염 후 T 세포 기억 형성의 역학을 보여줍니다Short Report Published on 2021-01-052022-09-10 Journal: eLife [Category] 치료기술, [키워드] adaptive antibodies antiviral immune response caused CD4 CD8 changes in characteristic clonal expansion clone coronavirus COVID-19 COVID-19 infection COVID-19 patients cross-reactive cross-reactivity dataset Diversity donors fraction global pandemic Human immune memory immune response infected cell infected cells Infection killing longitudinal majority memory memory formation memory T memory T cell memory T cells Mild mild case motif Occurrence Participation Phenotypes RepSeq resulting reveal SARS-CoV-2 SARS-CoV-2 coronavirus Sequencing T cell T cells T-cell T-cell receptor T-cell Response TCR TCR sequence TCR sequences the SARS-CoV-2 virus-specific antibodies [DOI] 10.7554/eLife.63502 PMC 바로가기 [Article Type] Short Report
Standardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling임상 및 가정 혈액 샘플링을 사용한 SARS-CoV-2 대유행의 혈청 조사를 위한 ELISA 프로토콜 표준화Article Published on 2021-01-042022-09-12 Journal: Nature Communications [Category] 진단, [키워드] analyses antibodies Antigen Blood collected convalescent costly COVID-19 pandemic COVID-19 patient Cross reactivity cross-reactivity diagnostic ELISA ELISA protocol flexible H1N1 HAI help HKU1 host response host responses IgG and IgM Immunity Infection Laboratory techniques and procedures large cohort MERS negative controls OC43 pandemic parameter performed positive controls protocol public health SARS-CoV-2 SARS-COV-2 infection SARS1 serology Seropositivity Serosurvey serum Specificities Spike proteins the SARS-CoV-2 the spike protein the United State threshold thresholds understanding United States validation viral infection viruses [DOI] 10.1038/s41467-020-20383-x PMC 바로가기 [Article Type] Article
Evolution of SARS-CoV-2: Review of Mutations, Role of the Host Immune SystemSARS-CoV-2의 진화: 돌연변이 검토, 숙주 면역 시스템의 역할Review Published on 2021-01-012022-09-11 Journal: Nephron [Category] 변종, [키워드] addition Cell China circulating variant common cold common cold coronavirus common cold Coronaviruses coronavirus Cross-immunity cross-reactivity deaths Deletion deletions disease disease severity drop encoding proteins Europe Evolution expected explain Factor followed by Frequency genes encoding Genome HCoVs hospitalizations host immune system humoral ICU admissions identify immune system Immunity immunization in viral increase in independent independent of Infection involved lead Mutation mutations outbreak pandemic PCR-positive polymerase Protein Reporting review role SARS-CoV-2 SARS-CoV-2 genes sequence severity spring Strains summer System the disease the epidemic the SARS-CoV-2 Vaccine variant Viral viral mutation Viral mutations virus [DOI] 10.1159/000515417 PMC 바로가기 [Article Type] Review