Rapid Biosensor of SARS-CoV-2 Using Specific Monoclonal Antibodies Recognizing Conserved Nucleocapsid Protein EpitopesArticle Published on 2022-01-272022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antigen antigenic peptide assist binding binding affinity biosensor caused characterized Combination conserved conserved epitope coronavirus Coronavirus disease 2019 coughing COVID-19 COVID-19 patient cultured virus develop diagnostic diagnostics diarrhea disease transmission epitope epitope peptide fatigue Fever investigated Isolation monoclonal antibody nucleocapsid pandemic Pathogens Rapid resulting SARS-CoV-2 SARS-CoV-2 variants sensitivity sore throat Specific specimen Substitution Symptom TCID Vaccine virus mutation was performed [DOI] 10.3390/v14020255 PMC 바로가기 [Article Type] Article
Pharmacokinetics of high-titer anti–SARS-CoV-2 human convalescent plasma in high-risk children고위험 소아에서 고역가 항-SARS-CoV-2 인간 회복기 혈장의 약동학Clinical Trial Published on 2022-01-252022-09-12 Journal: JCI Insight [Category] 임상, 진단, [키워드] age Analysis Anti-spike anti-Spike IgG antibody antibody kinetics antibody production Antibody titer Antibody titers appear characterized children convalescent plasma coronavirus COVID-19 declined develop disease Donor ELISA assays enrolled epitope Euroimmun evaluated expected exposure to funding IgG immunoglobulins Infectious disease Kinetics Kinetics of antibodies median age Mild Mild disease neutralization capacity neutralization titer neutralizing capacity NIH passive transfer performed pharmacokinetic pharmacokinetics plasma PROTECT receive recipient Research Safe SARS-CoV-2 Serious Adverse Event Serious Adverse Events severe disease Spike protein symptom onset transferred transfused transfusion Trial registration underlying condition underlying conditions unlikely virus neutralization assays weight while [DOI] 10.1172/jci.insight.151518 PMC 바로가기 [Article Type] Clinical Trial
Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells423 Published on 2022-01-252022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, COVID19(2023년), SARS, [키워드] A549 cell ACE2 Analysis angiotensin-converting enzyme 2 antibody bind binding blocked Cell cellular component Complication contribute CR3022 Endothelial cell endothelial cells Entry mechanism entry receptor enzyme epitope expressed expressing Extracellular facilitate filament protein HEK-293 cell HEK-293 cells host cell Human implication in viral inhibited Interaction knockdown lung neutralized Pathogenesis pathogenesis of COVID-19 performed Protein provide pseudotyped Pseudotyped virus purified RBD Receptor binding domain recognize reduced S-protein S-RBD SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2-S Significance significantly the SARS-CoV-2 Transmission Vaccines Vascular VIM vimentin viral entry virus with COVID-19 [DOI] 10.1073/pnas.2113874119 PMC 바로가기 [Article Type] 423
Insights on the mutational landscape of the SARS-CoV-2 Omicron variant receptor-binding domainSARS-CoV-2 Omicron 변이 수용체 결합 도메인의 돌연변이 환경에 대한 통찰력Article Published on 2022-01-242022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Amino acid analyses antibody antibody epitopes antibody escape antigenic antigenic drift breadth conformational Disruption domain driving epistasis epitope epitope-paratope Epitopes Evidence feature initial insight Interaction interface Mutation network analysis neutralization omicron Omicron variant Perturbation perturbations Point mutation predicted RBD RBD interface stability RBD mutations resulting SARS-CoV-2 sequence stability the RBD the SARS-CoV-2 therapeutic therapeutic antibodies Transmissibility variant variant of concern [DOI] 10.1016/j.xcrm.2022.100527 PMC 바로가기 [Article Type] Article
Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic AntibodiesOmicron: 심하게 돌연변이된 SARS-CoV-2 변이체는 ACE2에 대한 더 강한 결합을 나타내며 승인된 COVID-19 치료 항체를 잠재적으로 탈출Immunology Published on 2022-01-242022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding antibodies antibody approved Beta bind binding binding energy clinical trials complex conserved contribute COVID-19 COVID-19 therapy E484K electrostatic epitope escape etesevimab facilitate FDA free energy Gamma Hong Kong Immune escape immune response Infection investigated mAb mAbs monoclonal antibodies monoclonal antibody Mutagenesis Mutation neutralization neutralize new SARS-CoV-2 omicron Phase III clinical trials potency Protein RBD Receptor binding Receptor-binding domain reported SARS-CoV-2 sera significantly Sotrovimab South Africa spike mutations Spike protein Spread Substitution substitutions T478K the RBD the receptor-binding domain the Spike therapeutic therapeutic antibodies therapy Transmissibility vaccinee vaccinees variant variants virus [DOI] 10.3389/fimmu.2021.830527 PMC 바로가기 [Article Type] Immunology
The structure of a novel antibody against the spike protein inhibits Middle East respiratory syndrome coronavirus infectionsArticle Published on 2022-01-242022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] antibody cellular membrane contribute Critical Drug administration epitope escaped Fatality rate function Host host antibody response Human humans immunology Infection inhibit MERS-CoV Middle East molecular Molecular biology mutant neutralization Neutralizing Neutralizing activity neutralizing antibody outbreak provided RBD respiratory syndrome coronavirus responsible severe respiratory illness Spike protein structural biology structures supported the RBD the spike protein therapeutic United State Vaccine virion virus X-ray crystallography zoonotic [DOI] 10.1038/s41598-022-05318-4 PMC 바로가기 [Article Type] Article
Machine Learning Techniques for the Prediction of B-Cell and T-Cell Epitopes as Potential Vaccine Targets with a Specific Focus on SARS-CoV-2 Pathogen: A ReviewReview Published on 2022-01-242022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome antibody Antigen antigenic determinant approach B cell B-cell epitopes candidate caused changed composed coronavirus disease Coronavirus-2 costly COVID-19 Critical effective endemics Ensemble model Epidemics epitope epitope mapping epitope-based peptide vaccine Epitopes focus high mutation rate highlighting Human immune system identification identify immune-relevant determinants less machine learning outbreak Pandemics pathogen peptide Potential prediction PROTECT Protein public health reduced required Research review SARS-CoV-2 Specific strain systematic review target technique time-consuming trials vaccination Vaccine variants [DOI] 10.3390/pathogens11020146 PMC 바로가기 [Article Type] Review
Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 교차 변형 중화 사이트 매핑Coronaviruses Published on 2022-01-242022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyses antibody approved B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 bind binding biochemical Combination comparable conserved coronavirus cryo-EM decrease effective vaccine Efficacy epitope Epitopes evaluate exhibit exhibits Guidance identify loop mAbs mapping monoclonal antibodies monoclonal antibody neutralization neutralize Neutralizing potency pseudoviruses raised RBD Receptor-binding domain receptor-binding motif respiratory SARS-CoV-2 SARS-CoV-2 spike protein SD1 significantly Spike protein target tested the receptor-binding domain the SARS-CoV-2 the spike protein therapeutic Therapies Vaccine variant variants variants of concern Virological [DOI] 10.1080/22221751.2021.2024455 PMC 바로가기 [Article Type] Coronaviruses
Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infectionSARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.Comparative Study Published on 2022-01-242022-09-10 Journal: eLife [Category] 변종, 치료기술, 치료제, [키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type [DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study
Evidence of a SARS-CoV-2 double Spike mutation D614G/S939F potentially affecting immune response of infected subjectsResearch Article Published on 2022-01-212022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract Affect affecting approach binding affinity binding epitope characterized cleavage site Community COVID-19 COVID-19 positive subject D614G D614G mutation deep sequencing diffusion effort epitope evidence of evidenced Fiumicino HLA alleles identify immune response implication Infection Italy modulation MONITOR mutated Mutation next generation sequencing objective peptide Protein Proteins reported respiratory sample Result S939F SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants selective Sequencing analysis severity specific mutation spike spike mutations stability subject T-cell triggered unique viral infection was performed was used [DOI] 10.1016/j.csbj.2022.01.021 PMC 바로가기 [Article Type] Research Article