Cardiac arrhythmias in hospitalized patients with COVID-19: A prospective observational study in the western United StatesCOVID-19로 입원한 환자의 심장 부정맥: 미국 서부 지역의 전향적 관찰 연구Observational Study Published on 2020-12-282022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 임상, [키워드] analyzed arrhythmia Arrhythmias baseline characteristics bpm C-reactive protein cardiac Cardiac arrhythmia cardiac arrhythmias Characteristics characterized clinical outcomes collected complexes Complication Course COVID-19 COVID-19 patients detect disease enrolled explain Factor Follow-up heart heart rate hospital Hospitalized hospitalized patient in-hospital mortality incidence initial interleukin interleukin-6 investigated less medical records no difference non-survivor Non-survivors observation occurred overall mortality Patient patients patients’ medical records prospective observational study regions reported Sinus tachycardia survivor Survivors Tachycardia telemetry Treatment troponin United State ventricular ventricular arrhythmias ventricular fibrillation ventricular tachycardia with COVID-19 [DOI] 10.1371/journal.pone.0244533 PMC 바로가기 [Article Type] Observational Study
Evidence of SARS-CoV-2 Transcriptional Activity in Cardiomyocytes of COVID-19 Patients without Clinical Signs of Cardiac InvolvementArticle Published on 2020-12-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] absence activity addition affected alteration analysed assays asymptomatic patients Autopsy autopsy analysis cardiac Cardiomyocytes cell death clinical Clinical sign collected coronavirus COVID-19 COVID-19 patient death Deceased develop digital PCR disease displaying evidence of heart heart tissue immunofluorescence immunohistochemistry Injury investigated Involvement oedema Patient phenotype proportion Respiratory disease Respiratory failure RNA SARS-CoV-2 SARS-CoV-2 spike SIGN subcellular Surveillance transmission electron microscopy viral transcription [DOI] 10.3390/biomedicines8120626 PMC 바로가기 [Article Type] Article
Using Cardiovascular Cells from Human Pluripotent Stem Cells for COVID-19 Research: Why the Heart FailsPerspective Published on 2020-12-102022-10-04 Journal: Stem Cell Reports [Category] MERS, SARS, 신약개발, [키워드] acute respiratory syndrome Arrhythmias can be used Cardiac pathology cardiovascular cardiovascular cells cardiovascular disease Cell coronavirus coronavirus disease COVID-19 Cytokine storm death derivative disease modeling drug Drug screening Fail feature heart hPSCs Human infect Infection mice myocardial injury outbreak pandemic pathology Perspective poor prognosis provided receptor Respiratory complications resulting SARS-CoV-2 Scientific community STEM the disease therapeutic Therapies treat Vaccine virus [DOI] 10.1016/j.stemcr.2020.11.003 PMC 바로가기 [Article Type] Perspective
Telemedicine in Heart Failure During COVID-19: A Step Into the FutureCardiovascular Medicine Published on 2020-12-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Admission benefit Care caused change coronavirus Coronavirus disease 2019 COVID-19 decompensated heart failure detect discharge failure Follow-up Follow-up visit forward triage Future heart heart failure Hospitalization hospitals limitation lockdown Mortality pandemic paradoxical Patient patient mortality Patients at Home Prevent progression provide quarantine reduction remote monitoring step Symptom Telemedicine telerehabilitation the patient Treatment undergo virtual visits worldwide pandemic [DOI] 10.3389/fcvm.2020.612818 PMC 바로가기 [Article Type] Cardiovascular Medicine
The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular SystemCardiovascular Medicine Published on 2020-12-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome alleviate appear ARDS attenuate Cardiac arrhythmia cardiovascular cardiovascular complications cardiovascular system cause caused Cell clinical study Complication coronavirus coronavirus disease COVID-19 COVID-19 patients COVID-19 positive patient CXCL10 Cytokine storm deaths develop drug Effect elevated global pandemic hallmark heart help IL-2 IL-22 IL-6 IL-7 immune system immunomodulatory Immunosuppression induced infected case Infection lung Mesenchymal stem cells Mortality MSC MSCs myocardial injury myocarditis organ systems Patient Prevent primary site pro-inflammatory cytokine regeneration and repair role SARS-CoV-2 Severe case shown storm stromal cell suggested syndrome System the cytokine storm therapy Thromboembolism tissue repair TNFα [DOI] 10.3389/fcvm.2020.602183 PMC 바로가기 [Article Type] Cardiovascular Medicine
Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection여러 막 결합 세린 프로테이나제에 의한 SARS-CoV-2 S 단백질 프라이밍은 바이러스 감염력 및 전신 COVID-19 감염을 설명할 수 있습니다Review Published on 2020-12-062022-09-12 Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 진단, [키워드] α2-AP, α2-antiplasmin ACE2 ACE2, angiotensin-converting enzyme 2 activate addition Affect causative agent cause caused cell tropism circulating clinical observations Concentration contribute coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 infection COVID-19 pandemic death determine effective Exclusive or explain expression Factor HAI-1/SPINT1 heart host cells Infection infection rate information inhibitor inhibitors kidney kidney damage kidneys liver liver dysfunction Lungs MASPs, membrane-associated serine proteinases membrane fusion membrane-associated serine proteinases (MASPs) membrane-bound MERS, Middle East respiratory syndrome much higher myocardial injury Neurological complications organ other organ other organs PAI-1, plasminogen activator inhibitor 1 PCI, protein C inhibitor positive predominant proteinase QM/MD, quantum mechanical/molecular dynamics receptor relative SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS, Severe acute respiratory syndrome Sepsis Serine serine proteinase serpins significantly higher similarity spike (S) protein Spike protein SPINT1 SPINT2 structure–function relationship synergy term the disease the patient the SARS-CoV-2 thrombotic TMPRSS2 transmembrane transmission rate Treatment uPA, urokinase-type plasminogen activator Vaccine viral fusion viral spike protein viral spike proteins [DOI] 10.1074/jbc.REV120.015980 PMC 바로가기 [Article Type] Review
Protocol for an implementation study of an evidence-based home cardiac rehabilitation programme for people with heart failure and their caregivers in Scotland (SCOT:REACH-HF)Cardiovascular Medicine Published on 2020-12-042022-10-28 Journal: BMJ Open [Category] Coronavirus, Fulltext, MERS, SARS, [키워드] Analysis approval approved assessment baseline burden Cardiology Care Caregiver conducted dissemination Ethics events Evidence facilitate facilitator failure finding Follow-up framework Governance Health heart heart failure implementation Implementation study IMPROVE include International Intervention involved ISRCTN National National Health Service NHS Nurses outcome outcomes Participants Patient peer-reviewed physiotherapists professional protection protocol Qualitative recorded rehabilitation rehabilitation medicine reported Research Research question scale service Specific university West written Informed Consent [DOI] 10.1136/bmjopen-2020-040771 PMC 바로가기 [Article Type] Cardiovascular Medicine
Long-term ACE Inhibitor/ARB Use Is Associated With Severe Renal Dysfunction and Acute Kidney Injury in Patients With Severe COVID-19: Results From a Referral Center Cohort in the Northeast of France장기간 ACE 억제제/ARB 사용은 중증 COVID-19 환자의 중증 신장 기능 장애 및 급성 신장 손상과 관련이 있습니다: 프랑스 북동부의 추천 센터 코호트 결과Article Published on 2020-12-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 바이오마커, [키워드] 95% CI 95% confidence interval ACE ACEi ACEi/ARB acute kidney Acute kidney injury Acute respiratory failure Analysis angiotensin angiotensin receptor blocker Angiotensin-converting enzyme angiotensin-converting enzyme inhibitor ARB association biochemical Biomarker center characteristic consecutive patient consecutive patients converting enzyme inhibitor coronavirus disease Coronavirus disease 2019 COVID-19 creatinine daily dose diagnosed disease Enzyme inhibitor evaluated France heart increase in increased risk independent predictors inflammatory reaction influence kidney Lisinopril liver dysfunction liver dysfunctions Logistic regression analysis longitudinal cohort study lung marker multivariable nitrogen Occurrence Odds ratio outcomes Patient patients performed phosphorus predict predictor receiver operating characteristic receptor receptor blocker Referral repeated measures Respiratory failure Result retrospective risk SARS-CoV-2 severe coronavirus disease severe COVID-19 severity treated urea urea nitrogen were assessed [DOI] 10.1093/cid/ciaa677 PMC 바로가기 [Article Type] Article
The endothelium as Achilles’ heel in COVID-19 patientsComment Published on 2020-12-012023-07-12 Journal: Cardiovascular Research [Category] SARS, [키워드] COVID-19 endothelial cells Endotheliitis heart [DOI] 10.1093/cvr/cvaa327 PMC 바로가기 [Article Type] Comment
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytesSARS-CoV-2는 인간 심근세포를 감염시키고 세포독성 효과를 유도합니다Article Published on 2020-12-012022-09-11 Journal: Cardiovascular Research [Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Apoptosis blocked Caco-2 cardiac injury cardiomyocyte Cardiosphere Cardiotoxicity cathepsin cathepsin-dependent Cathepsins caused cell lines Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytotoxic effect demonstrated dependent on direct infection double-stranded Effect elevated enzyme expression global pandemic glycoprotein heart Heart slice higher risk in vitro Increasing induce infect Infection infection with SARS-CoV-2 infections Inflammation inhibited Injury interferon lead Lung injury marker Mortality oxygen Particle pathway Pathways Patient reactive oxygen Remdesivir respiratory RNA sequencing SARS-CoV-2 SARS-COV-2 infection secondary to severe acute respiratory syndrome Coronavirus spike glycoprotein Spike protein strain Stress supernatant supernatants tissue transcriptional response up-regulation Viral viral infection viral particle Viral particles Viral RNA viral spike viral spike protein [DOI] 10.1093/cvr/cvaa267 PMC 바로가기 [Article Type] Article