Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19Review Published on 2020-09-252022-10-30 Journal: Molecules [Category] COVID-19, [키워드] activities Anti-inflammatory antioxidant appear applied Compromised concomitance conditions Coronavirus disease 2019 COVID-19 Critical Diseases Effect effective energy metabolism ENhance Evolution example expected Fighting function Gender generate Glycolysis Health Host host cell Impact in viral increase individual infections Innate immunity MAVS melatonin metabolite Mitochondria mitochondrial Mitochondrial function Mortality outcome oxygen pandemic Pandemics pathogen pathogen’ Pathogens producing Protective reduce reduced required Respiratory disease seasonal flu severity Support susceptibility System targeting Tolerance viral infection viral infections viral infectious diseases virus infection [DOI] 10.3390/molecules25194410 PMC 바로가기 [Article Type] Review
Selenium and selenoproteins in viral infection with potential relevance to COVID-19COVID-19와 잠재적 관련성이 있는 바이러스 감염의 셀레늄 및 셀레노단백질Review Published on 2020-09-102022-09-10 Journal: Redox Biology [Category] SARS, 치료제, [키워드] adaptive Adaptive immunity association benefit Chinese patient Chinese patients contribute Controlled trial COVID-19 COVID-19 patient COVID-19 patients COVID-19-associated inflammation Culture cure rate cytokine Cytokine activation doses Ebselen ENhance ER stress evade example explain expression functions Health Host host immunity host response hosts IL-6 immune response Immunity in viral incidence increased expression Infection inhibit SARS-CoV-2 inhibitor involved linear maturation mechanism mediator metabolite morbidity morbidity and mortality Pathogenesis pathogenic pharmacological play roles positive potential benefit potential benefits Prevent Proteases PROTECT Protective provide randomised rationale Recognition Redox-active selenium species reduced reducing required RNA SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 protease Selenium selenoprotein Selenoproteins serum sample serum samples severity significantly significantly higher Trace element Viral viral infections viral pathogenesis virus viruses with COVID-19 [DOI] 10.1016/j.redox.2020.101715 PMC 바로가기 [Article Type] Review
Quantitative proteomic analysis of the tizoxanide effect in vero cellsArticle Published on 2020-09-072022-10-04 Journal: Scientific Reports [Category] 치료제, [키워드] Analysis antimicrobial effect antiviral activity approach approved Bacteria biological processes Biotechnology Brazil Cell cell metabolism cells circulating clinical trial clinical trials COVID-19 differentially expressed effective engage FASN in vitro in vitro results mechanism metabolite microorganisms Modification nitazoxanide Protein proteomic proteomics RNA Signal transduction tizoxanide translation Treatment USA Vero Cell viruses [DOI] 10.1038/s41598-020-71634-2 PMC 바로가기 [Article Type] Article
Does zinc supplementation enhance the clinical efficacy of chloroquine/hydroxychloroquine to win today’s battle against COVID-19?Research article Published on 2020-09-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 신약개발, 임상, 치료제, [키워드] antimalarial antiviral effects candidate cardiovascular disease Chloroquine chloroquine/hydroxychloroquine chronic pulmonary disease Clinical efficacy clinical study clinical trials Combination Coronavirus replication COVID-19 COVID-19 patients deficiency diabetes effective Elderly patient ENhance Extracellular HCQ host cells Hydroxychloroquine inhibit interfere intracellular vesicle limit lysosome metabolite monotherapy morbidity and mortality occur reducing RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication tested therapy Treatment virus Zinc zinc supplementation [DOI] 10.1016/j.mehy.2020.109815 [Article Type] Research article
The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patientsResearch article Published on 2020-09-012022-10-05 Journal: Redox Biology [Category] SARS, 치료제, [키워드] 27-Hydroxycholesterol administration Antiviral caused cholesterol common cold control group coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic COVID-19 patient cytotoxicity disease HCoV-OC43 identify in vitro inhibit inhibitory activity marker metabolite no correlation Oxysterols physiological positive Redox imbalance reduction in SARS-CoV-2 Serum level severe COVID-19 severity shown significantly significantly increased Specific subject the disease variety viral pathogens worsening [DOI] 10.1016/j.redox.2020.101682 [Article Type] Research article
Importance of Dietary Changes During the Coronavirus Pandemic: How to Upgrade Your Immune ResponsePublic Health Published on 2020-08-272022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] addition association balanced diet change complications of COVID-19 coronavirus country COVID-19 COVID-19-related death death deficiency dietary dietary habit Effect function Gut immune response Immune status immune system immunodeficiency Importance inflammatory state intermittent fasting macronutrients metabolic parameter metabolite Microbiome micronutrients microorganisms New coronavirus outcome pandemic pathogenic virus populations preventing infection Probiotics public health question response Spread Upgrade variables [DOI] 10.3389/fpubh.2020.00476 PMC 바로가기 [Article Type] Public Health
Probiotics at War Against Viruses: What Is Missing From the Picture?Microbiology Published on 2020-08-202022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Against Antibiotics Antiviral antiviral activity Antiviral agents Bacteria Bacteriocins Bifidobacterium cause Cell cholesterol co-infecting COVID-19 COVID-19 patients decrease develop Diseases Effect effective greater gut microbiota help Human Immunity immunomodulating Infection infections intervene intestinal lactic acid lactobacillus metabolite metabolites missing Other over Prevent probiotic bacteria Probiotics reduce reduction in report reported Research risk SARS-CoV-2 secondary infections serum strain therapeutic drug treat treated viral infection virus virus infection viruses [DOI] 10.3389/fmicb.2020.01877 PMC 바로가기 [Article Type] Microbiology
Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?Immunology Published on 2020-08-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE ACE2 activated Activation Ang II angiotensin Angiotensin II bind binding bradykinin cell entry Coagulation complex Contact contact system convert COVID-19 D-dimer levels Defense described downregulating edema effective factor XII host response inactivation Infection Inflammatory responses innate immune response intrinsic investigated involved lack lung metabolite negative feedback loop pathophysiology plasma Protective proteolytic RAS resulting SARS-CoV-2 System Treatment understanding up-regulated vascular permeability [DOI] 10.3389/fimmu.2020.02014 PMC 바로가기 [Article Type] Immunology
Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 InfectionImmunology Published on 2020-08-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] Adverse anti-viral activity antibodies approach co-morbidities coronavirus disease COVID-19 Critical damaged tissue deficiency drive driven by Effect environmental exposure Evidence exacerbate exacerbated fatty acids highlight identify immunosuppressive independent risk factor induce Infection Inflammation influenza infection lipoxins maresins mediator metabolic factor metabolite morbidity and mortality obesity overcome pandemic pharmacological interventions Polyunsaturated promote protectins pulmonary inflammation resolvins respiratory responsible SARS-CoV-2 SARS-COV-2 infection susceptibility tissues [DOI] 10.3389/fimmu.2020.01997 PMC 바로가기 [Article Type] Immunology
Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans박테리아 대사 산물에 의한 화학 감각 뉴런 유전자 발현의 즉각적인 활성화는 Caenorhabditis elegans에서 별개의 순환 GMP 의존 경로에 의해 선택적으로 유도됩니다Research Article Published on 2020-08-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation addition animals Author avoidance bacterial metabolite Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans calcium canonical cGMP chemosensory cyclic GMP dependent on detect dissect dynamic elegan elegans engage expression external environment gene encoding Gene Expression highlighting Immediate induce intracellular signaling lead Ligand mechanism metabolite metabolites microbial modulate nervous system neuroendocrine Neuron neuronal neurons P . aeruginosa pair pathogen pathogenic pathogenic bacteria pathogenic bacterium pathway produced Protective Protein protein kinase Pseudomonas aeruginosa required response selective sensation sensory neuron sensory neurons Signal transduction Signaling signaling pathway subunit TGF-β Transcription transcriptional transcriptional response turn [DOI] 10.1371/journal.pgen.1008505 PMC 바로가기 [Article Type] Research Article