HBV upregulated triggering receptor expressed on myeloid cells-1 (TREM-1) expression on monocytes participated in disease progression through NF-Kb pathwayArticle Published on 2021-02-012023-06-13 Journal: Clinical immunology (Orlando, Fla.) [Category] B형 간염, [키워드] HBV Liver cirrhosis monocyte TREM-1 [DOI] 10.1016/j.clim.2020.108650
Sex differences in immune responses to SARS-CoV-2 in patients with COVID-19COVID-19 환자에서 SARS-CoV-2에 대한 면역 반응의 성별 차이Immunology & Inflammation Published on 2021-01-292022-09-12 Journal: Bioscience Reports [Category] 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine alanine aminotransferase ALT analyzed APACHE II aspartate Aspartate aminotransferase AST Biomarkers C-reactive protein C-reactive protein (CRP CD3 CD4 CD8 chronic circulating clinical feature Clinical features clinical manifestation clinical manifestations Cohort community-acquired pneumonia coronavirus correlation COVID-19 COVID-19 patient COVID-19 patients CRP Decreased diagnosed Estrogen explain female females healthy controls immune response immune responses independent independent of Infectious disease Laboratory lymphocyte male monocyte patients patients with COVID-19 Peripheral blood Physiology Prevalence proportion proportions respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 patient severity of COVID-19 Sex sex-specific specificity subset T cell Viral [DOI] 10.1042/BSR20202074 PMC 바로가기 [Article Type] Immunology & Inflammation
Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in PigsImmunology Published on 2021-01-282022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] animal Antigen antigen expression antigens assessment breadth c-di-AMP adjuvant cell cultures cellular cellular response classical concerning coronavirus DCs dendritic cell dimeric employment encoding Fever FIVE hemagglutinin Host human cells humans humoral humoral and cellular immune response immune immune responses immunological induce influenza vaccines Influenza virus influenza virus H5N1 inherent monocyte monophosphate mRNA nucleoprotein offer packaged pandemic Particle Pestivirus pig polyplexes promote question receiving remained replicative replicon reported response RNA self-amplifying replicon RNA target Vaccine design virus virus replicon particle [DOI] 10.3389/fimmu.2020.622385 PMC 바로가기 [Article Type] Immunology
Single-cell RNA sequencing reveals SARS-CoV-2 infection dynamics in lungs of African green monkeys단일 세포 RNA 시퀀싱은 아프리카 녹색 원숭이의 폐에서 SARS-CoV-2 감염 역학을 보여줍니다Research Article Published on 2021-01-272022-09-10 Journal: Science Translational Medicine [Category] 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African green monkey African green monkeys Alveolar macrophages Analysis animal model animal models animals best Cell cellular debris clearance contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 dataset degrade determine Factor genomic RNA green monkeys Host Host immune response host response host responses identify immune cell population immune cell populations immune responses in vivo inactivated Indicator infected cell infected cells Infection infiltrating Inflammatory response information inoculated knowledge lung Lungs Lymph node Macrophage macrophages mediastinal lymph nodes Mild mild to moderate moderate monocyte Monocyte-derived macrophages occur Pathogenesis phagocytosis pneumocyte Pneumocytes provide recruited replicate Replication respiratory respiratory tract responsible reveal RNA RNA sequencing SARS-CoV-2 SARS-COV-2 infection Sequencing sequencing data severe acute respiratory syndrome Coronavirus Single-cell RNA sequencing switching therapeutic targets valuable resource Viral viral genome viral replication virus virus replication while [DOI] 10.1126/scitranslmed.abe8146 PMC 바로가기 [Article Type] Research Article
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages기관지폐포 세척액의 선천적 및 적응 면역 단일 세포 프로파일링을 통해 심각한 COVID-19와 경증 구별Article Published on 2021-01-212022-09-12 Journal: Cell Research [Category] 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] adaptive Alveolar macrophages Anti-inflammatory BAL bioinformatics Bronchoalveolar lavage build CD4 CD8 Cell change Characteristics characterized clearance contribute COVID-19 Critical Evidence expressing fibrosis functions Gene Expression Genome-wide analysis of gene expression host immune system Hyperinflammatory immune immunopathology in viral Innate immunity involved lung Lung epithelial cells Macrophage marker Mild monocyte naïve neutrophil Non-COVID-19 Patient Pneumonia proportion reveal single-cell Stress T-cell Trajectories trajectory undergo vice [DOI] 10.1038/s41422-020-00455-9 PMC 바로가기 [Article Type] Article
Monocytes and macrophages in COVID-19: Friends and foesReview Article Published on 2021-01-142023-06-15 Journal: Life sciences [Category] MERS, SARS, [키워드] COVID-19 Inflammation Macrophage monocyte SARS-CoV-2 [DOI] 10.1016/j.lfs.2020.119010 PMC 바로가기 [Article Type] Review Article
Higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients might be correlated with inhibition of Type I IFN signaling경증 COVID-19 환자에서 단핵구 주화성 단백질 1의 더 높은 발현은 I형 IFN 신호의 억제와 상관관계가 있을 수 있습니다Research Published on 2021-01-072022-09-10 Journal: Virology Journal [Category] 치료제, [키워드] acute respiratory syndrome characterized chemokine Chemokine receptor chemokine receptors chemokines chemotactic China city coronavirus coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients demonstrated detect elevated enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epidemiological evaluate expressed expression expression level expression levels finding Host immune response IFN IFN signaling immunopathological Infection interferon IRF3 MCP-1 mechanism Mild mild case mild cases mild COVID-19 patient mild COVID-19 patients monocyte Patient polymerase chain polymerase chain reaction potential therapeutic target potential therapeutic targets Protein provide real-time polymerase chain reaction receptor Regulatory respiratory Result Serum level serum levels severe acute respiratory syndrome Coronavirus severe coronavirus disease shown signaling molecule signaling molecules significant negative correlation Type was measured [DOI] 10.1186/s12985-020-01478-9 PMC 바로가기 [Article Type] Research
Targeting the NO-cGMP-PDE5 pathway in COVID-19 infection. The DEDALO projectCOVID-19 감염에서 NO-cGMP-PDE5 경로를 표적으로 합니다. 데달로 프로젝트Article Published on 2021-01-012022-09-11 Journal: Andrology [Category] SARS, 임상, 치료제, [키워드] acting activated T cells administration alveolar ANG-II anti-inflammatory response biological drug biological drugs cause Cell cGMP clinical trial clotting Complication complications of COVID-19 contraindication contraindications COVID-19 COVID-19 disease COVID-19 infection cyclic GMP cytokine cytokine release Cytokine storm Cytokines diabete diabetes Diabetes Mellitus Diabetic diffusion disease downregulation drug dysregulation endothelial Endothelial cell endothelial cell damage Evidence expressed favor fibrosis IL-6 immune system implication IMPROVE infiltration inhibiting interstitial interstitial pneumonia limit Liver function low-grade inflammation Lungs material men mesenchymal cells Metabolic diseases modulating monocyte Necrosis nitric oxide Numerous offer ongoing trial ongoing trials outbreak oxygen pandemic pathophysiology pathway Patient patients with COVID-19 PDE5 inhibitor PDE5 inhibitors performed positive presenting pro-inflammatory cytokines pulmonary artery pulmonary fibrosis raise reducing renal impairment resource respiratory respiratory infection responsible severe COVID-19 disease Sildenafil smooth muscle smooth muscle cell smooth muscle cells stability storm switching systematic review systemic disease T cells targeting temperature thrombotic Thrombotic complications transition type 2 diabete Type 2 diabetes mellitus Vascular vessel widespread [DOI] 10.1111/andr.12837 PMC 바로가기 [Article Type] Article
Elevated plasma sTIM-3 levels in patients with severe COVID-19중증 COVID-19 환자의 혈장 sTIM-3 수치 상승Clinical Trial Published on 2021-01-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 임상, [키워드] activated Activated neutrophils activated T cell activated T cells Activation analyzed association CD25 Clinical outcome coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection disease severity disorder downregulation dysregulation examined Exhaustion fraction high plasma level high plasma levels Hospital admission ICU ICU treatment immune activation immune dysregulation Immunoglobulin Infection intensive care intensive care unit leukocyte macrophage activation marker monocyte mucin myeloperoxidase N-terminal N-terminal pro-B-type natriuretic peptide neutrophil neutrophil activation Neutrophils outcome oxygen parameter Pathogenesis pathogenesis of COVID-19 Patient peptide plasma Plasma levels positively correlated pro-B-type natriuretic peptide Respiratory failure severe COVID-19 subset T cell T cells T-cell T-cell activation TIM-3 Treatment [DOI] 10.1016/j.jaci.2020.09.007 PMC 바로가기 [Article Type] Clinical Trial
The role of chest CT in management of asymptomatic SARS-CoV-2 infections: A longitudinal multi-center study in Chongqing, China무증상 SARS-CoV-2 감염 관리에서 흉부 CT의 역할: 중국 충칭의 다기관 종단 연구Multicenter Study Published on 2021-01-012022-09-12 Journal: International Journal of Medical Sciences [Category] 진단, [키워드] Abnormalities analyzed Asymptomatic asymptomatic infection asymptomatic infections Chest CT chest CT scan China Chongqing clinical Clinical data clinical feature condition consolidation COVID-19 CT scan CT scans enrolled Evidence Evolution exhibited feature Follow-up GGO group groups individual involved longitudinal lung management Manifestations men Mild monocyte monocyte count Multiple outcome PCR tests positive positive result progression Radiographic RT-PCR testing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RT-PCR test severe pneumonia Significant significant difference significant differences Society the median women [DOI] 10.7150/ijms.50705 PMC 바로가기 [Article Type] Multicenter Study