overlap – Page 30 – Communicable Diseases Research

Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

죽상경화증 퇴행 동안 플라크 대식세포의 전사체에 대한 후성유전체 분석은 Wnt 신호 전달 경로의 활성화를 보여줍니다

Research Article

Published on 2014-12-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

The Nuclear Immune Receptor RPS4 Is Required for RRS1 SLH1 -Dependent Constitutive Defense Activation in Arabidopsis thaliana

핵 면역 수용체 RPS4는 Arabidopsis thaliana에서 RRS1 SLH1 -의존적 구성 방어 활성화에 필요합니다

Research Article

Published on 2014-10-232022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] absence activate Activation Agrobacterium allele Amino acid analysis Arabidopsis Arabidopsis thaliana Bacterial C-terminal Cell complex conducted Defense disease DNA binding domain dominant downstream effector effectors ENCODE function Genes Genetic genetic screen growth hypotheses identify Immune receptor immune receptors immune responses Immunity inactive insertion leucine loss-of-function mutation loss-of-function mutations mammalian mechanism motif mutant mutants Mutation NLR NLRs nuclear nucleotide overlap pathogen performed plant plants Protein Pseudomona Pseudomonas R genes receptor Recognition recognize required rescued responses RRS1 secretion Signaling significantly temperature transcribed transcriptional transcriptional activation transcriptional change Trigger triggers type III wild type
[DOI] 10.1371/journal.pgen.1004655 PMC 바로가기 [Article Type] Research Article

Classic Selective Sweeps Revealed by Massive Sequencing in Cattle

소에서 대규모 시퀀싱으로 밝혀진 클래식 선택적 스윕

Research Article

Published on 2014-02-272022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major affected affecting allele among others analysis ancestors applied approach association autosomal SNP candidate gene cattle classic CLR complementary complexity Composite current detect detectable disequilibrium Domestication ERBB4 Evidence faster fixation Fleckvieh followed by Genetic genetics Genome genome-wide association genomic genomic region help homozygosity Human identify iHS IMPROVE KIT life style likelihood ratio linkage Linkage disequilibrium massive MC1R MITF multiple statistical metrics NRG4 overlap Perspective phenotype Phenotypes physical Protein QTL mapping QTLs Ratio re-sequencing Region regions Result Revealed score sensory perception Sequencing sequencing technology significantly somatic cell somatic cell count speciation subsequent TAS2R16 temper thought TMEM132D traits utility whole genome Whole genome sequencing
[DOI] 10.1371/journal.pgen.1004148 PMC 바로가기 [Article Type] Research Article

Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses

전사체 메타 분석에 의해 발견된 중추신경계 장애와 암 사이의 역병환에 대한 분자적 증거

Research Article

Published on 2014-02-202022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] (Alzheimer's disease Alzheimer's disease Analysis Author biological processe biological processes cancers Candidates causes CENTRAL CNS CNS disorder Colorectal Comorbidity complex disorders conditions conducted contribute decrease Degradation deregulated deregulation described disease disorder disorders downregulated downregulation driven by Drug repurposing drug treatment drug treatments epidemiological Evidence expected expression Factors Gene Genetic genetic factors Hypothesis incidence inverse lung mechanism meta-analysis molecular nervous observé opposite overlap Parkinson's Disease pathway Pathways Patient PIN1 Probability progression promote Prostate protective effect Protein related risk Schizophrenia System tested transcriptomic Treatment understanding upregulated upregulation Wnt
[DOI] 10.1371/journal.pgen.1004173 PMC 바로가기 [Article Type] Research Article

MTL –Independent Phenotypic Switching in Candida tropicalis and a Dual Role for Wor1 in Regulating Switching and Filamentation

MTL – Candida tropicalis의 독립적인 표현형 전환과 전환 및 필라멘트 조절에서 Wor1의 이중 역할

Research Article

Published on 2013-03-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] addition ascomycete Author C. albican C. albicans Candida albican Candida albicans Candida tropicalis Cell cell type cell types cells characterized colonization conserved Deletion dependent on different Efficiency Epigenetic expression filament fungal fungi Gene growth heterozygous homozygous Host in addition to independent independent of induce Infection Interaction locus mammalian master regulator overexpression overlap pathogen pathogenic phenotypic Program promote regulate regulated Regulating Regulation related retained reveal role sexual reproduction switching these cell These cells transcription factor transcription factors transcriptional regulator transition undergo white cell white cells Wor1 yeast form
[DOI] 10.1371/journal.pgen.1003369 PMC 바로가기 [Article Type] Research Article

Molecular Networks of Human Muscle Adaptation to Exercise and Age

운동과 나이에 대한 인간 근육 적응의 분자 네트워크

Research Article

Published on 2013-03-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 13q21 1q12 activated all-trans-retinoic acid Activation adaptation age Ageing all-trans-retinoic acid alteration Analysis applicability aryl-hydrocarbon receptor signaling ATRA Author chance chromosomal Cohort cohorts component Compound continuum contributed developmental processe developmental processes Differential analysis displaying DNA topoisomerase down-regulation driven by EET endurance exercise endurance exercise training Epigenetic events exercise exhibited found Gain Gene gene-expression gene-networks gene-set gene-sets generate Genes growth Health care Health care system health care systems Human hypertrophic response hypertrophic responses hypertrophy identify Impact independent individual individuals Ingenuity Pathway Analysis inhibited Interaction IPA lean mass life loci Longevity mimicking molecular molecular network molecular networks mTOR muscle muscle age muscle growth Musculoskeletal network Older overlap pathway phenotype physical activity post-transcriptional processe post-transcriptional processes profile proportion Quality of life Rapamycin reduced referred to regulated related resistance-exercise training RET retinoic acid ribosomal genes rising risk RNA signature RNA signatures rRNAs RXR sarcopenia sarcopenic Serotonin Signaling significantly Society stream subject topoisomerase transcript unique Z-score
[DOI] 10.1371/journal.pgen.1003389 PMC 바로가기 [Article Type] Research Article

A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)

게놈 전체에 걸친 통합 게놈 연구는 엡스타인-바 바이러스 핵 항원 1(EBNA-1)에 대한 항체에 영향을 미치는 유전적 요인을 국소화합니다.

Research Article

Published on 2013-01-102022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major Adult adverse outcome adverse outcomes analysis Analysis antibody antibody levels Antigen approach association Author Autoimmune disorders best Burkitt lymphoma Cancer cancers Candidates chromosome chromosome 6 concerning dataset disease Disease progression DQB1 DRB1 EBV Epstein Barr virus Epstein-Barr virus Evidence evidence of examined expression data Factor family members focus foreign antigen foreign antigens found Gene Gene Expression Genetic genetic factors Genome HLA HLA locus HLA-DQB1 HLA-DRB1 Hodgkin lymphoma Host human leukocyte antigen IgG antibodies IgG antibody immune function immune system independent individual infect Infected Infection infectious Infectious disease infectious mononucleosis investigated involved joint leukocyte linkage loci locus lupus erythematosus lymphocyte lymphoproliferative disorders malignancies malignancy measure mechanism MHC class MHC class II multiple sclerosis nasopharyngeal lymphoma not found nuclear overlap P -value pathogen Pathogens prevalent provide regulate related replicated Research severe complication severe complications severe disease significantly SNP SNPs susceptibility susceptibility loci systemic lupus erythematosus T cells virus was obtained
[DOI] 10.1371/journal.pgen.1003147 PMC 바로가기 [Article Type] Research Article

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

Research Article

Published on 2011-10-272022-10-29
Journal: PLoS Pathogens
[Category] Coronavirus, MERS,

[키워드] Activation acute respiratory syndrome anti-infective drug Antiviral antiviral target approach Author automated Bacteria binding blocked common cold viruses CoV CoV-229E CoVs cyclophilin cyclosporin A Cytokine dysregulation demonstrated derivative different drug element Epidemics Factor FKBP1A FKBP1B fungi Host host cell host protein Human identification identify Immune cell include induce Infection Infectious Bronchitis Virus inhibited inhibitor Interaction interaction partner interleukin 2 involved led to maintain metabolism modulate Neurological disease non-structural protein nsp1 organism outbreak overlap parasites pathogen Pathogenesis pathway PPIA PPIB PPIG PPIH Protein Replication SARS-CoV severe SARS suggested Systems biology target targets tested Vaccine Viral protein virus virus virus replication Virus-host interaction viruses
[DOI] 10.1371/journal.ppat.1002331 PMC 바로가기 [Article Type] Research Article

A Three-Stemmed mRNA Pseudoknot in the SARS Coronavirus Frameshift Signal

Research Article

Published on 2005-06-172022-10-28
Journal: PLoS Biology
[Category] Coronavirus,