Neutralising antibody escape of SARS-CoV-2 spike protein: Risk assessment for antibody-based Covid-19 therapeutics and vaccinesSARS-CoV-2 스파이크 단백질 중화 항체 탈출: 항체 기반 Covid-19 치료제 및 백신에 대한 위험 평가Review Published on 2021-11-012022-09-11 Journal: Reviews in Medical Virology [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Affect African antibody B.1.1.7 B.1.351 bamlanivimab BNT162b2 Casirivimab circulating clades Combination convalescent convalescent plasma convergent evolution COVID-19 Deletion E484K Efficacy etesevimab focus hotspot Imdevimab immune Immune escape immunoglobulins inventory L452R LY-CoV555 LyCoV016 monoclonal antibodies mRNA mRNA-1273 Mutation mutations N439K N501Y neutralising neutralising antibody P.1 P.2 Phylogenetic polyclonal polyclonal immunoglobulins. Protein RBD Receptor binding domain REGN10933 REGN10987 Risk assessment S477N SARS-CoV-2 SARS-CoV-2 spike serum South spike Spike protein Strains target Therapeutics Vaccine Vaccines variants of concern Y453F [DOI] 10.1002/rmv.2231 PMC 바로가기 [Article Type] Review
Synthesis of novel calcium channel blockers with ACE2 inhibition and dual antihypertensive/anti-inflammatory effects: A possible therapeutic tool for COVID-19ACE2 억제 및 이중 항고혈압/항염 효과를 갖는 신규 칼슘 채널 차단제 합성: COVID-19에 대한 가능한 치료 도구Article Published on 2021-11-012022-09-11 Journal: Bioorganic chemistry [Category] SARS, 치료제, [키워드] ACE2 ACE2 binding ACE2 receptor activity addition Anti-inflammatory anti-inflammatory effect antihypertensive agent Bioisosters blocker blocking activity calcium calcium channel CCB CCBs cells Comorbidity Compound consequence COVID-19 COVID-19 infection COVID-19 patients CRP Efficacy evaluate evaluated exhibited highest hypertension IL-6 inhibitory effect MOST Nifedipine protective effect pyrimidines RBD reference standard researcher risk factor Risk factors SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 Spike RBD screened seriousness spike suppression synthesis tested therapeutic THP-1 THP‐1 cells. [DOI] 10.1016/j.bioorg.2021.105272 PMC 바로가기 [Article Type] Article
Titers of SARS CoV-2 antibodies in cord blood of neonates whose mothers contracted SARS CoV-2 (COVID-19) during pregnancy and in those whose mothers were vaccinated with mRNA to SARS CoV-2 during pregnancy산모가 임신 중 SARS CoV-2(COVID-19)에 감염되었거나 산모가 임신 중 SARS CoV-2에 대한 mRNA 예방접종을 받은 산모의 제대혈에서 SARS CoV-2 항체 역가Article Published on 2021-11-012022-09-11 Journal: Journal of perinatology : official journal of the [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody titer Blood Cord blood COVID-19 during pregnancy group immunity after vaccination infected with SARS-CoV-2 Infection mother mRNA Neonatal Neonate Neonates Pregnancy Protein Proteins SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 spike protein significantly higher Spike protein tested titer titers women [DOI] 10.1038/s41372-021-01216-1 PMC 바로가기 [Article Type] Article
Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis다발성 경화증에서 항 CD20 요법과 함께 SARS-CoV-2 mRNA 백신 접종 후 체액 면역 반응Article Published on 2021-11-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott Abbott Laboratories anti-CD20 anti-CD20 therapy B-cell binding domain BNT162b2 BNT162b2 mRNA Booster vaccine CD20 clinical clinical trials COVID-19 COVID-19 vaccine depleting determine domain Efficacy exposure to FIVE Future humoral IgG immune protection immune response immunogenicity Immunoglobulin Immunoglobulin G implication investigated monoclonal antibody mounted mRNA vaccination multiple sclerosis Ocrelizumab Patient patients patients treated positive Predictive Predictive value receiving SARS-CoV-2 SARS-CoV-2 IgG II Quant assay SARS-CoV-2 spike SARS-CoV-2 spike receptor-binding domain SARS-CoV-2 vaccine second dose second dose of vaccine seronegative seropositive the SARS-CoV-2 therapy treated patient Treatment vaccination Vaccine vaccine efficacy were measured [DOI] 10.1016/j.msard.2021.103251 PMC 바로가기 [Article Type] Article
Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccineResearch Article Published on 2021-10-292022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory syndrome addition antibody Beta cellular clinically Complete coronavirus coronavirus disease COVID-19 deaths delivery description high-density immune responses isolate Last mice Microarray neutralize pandemic provide provided SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine single dose subunit the vaccine These data vaccination Vaccine Vaccines variants virus [DOI] 10.1126/sciadv.abj8065 PMC 바로가기 [Article Type] Research Article
A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challengeArticle Published on 2021-10-282022-10-04 Journal: NPJ Vaccines [Category] 비임상, [키워드] Administered animal Antibody Response Antibody titer B.1.1.7 B.1.351 B.1.351 variant Beta comparable Coverage disease dose evaluated evidenced ferritin Formulation groups hamster High dose intranasal intranasally low-dose lung Lung pathology nasal PROTECT Protective Protein vaccines reduced regimens SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 variant Support Syrian Golden hamsters vaccination Vaccinations Vaccine variant viral burden viral infection viral replication virus VoC WA1 weight loss [DOI] 10.1038/s41541-021-00392-7 PMC 바로가기 [Article Type] Article
Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants최근에 등장한 SARS-CoV-2 변이체의 수용체 결합에 대한 분자적 통찰력Article Published on 2021-10-202022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 치료제, [키워드] ACE2 ACE2-RBD Alpha angiotensin Beta binding binding affinity cells changes in complexes crystal structure crystal structures domain enzyme examined FIVE Gamma hACE2 hACE2 protein help human ACE2 human Angiotensin-converting enzyme identify increase in information Interaction lack molecular molecular basis Multiple mutants Mutation Prevent Prophylactic Protein pseudovirus pseudoviruses RBD receptor Receptor binding Receptor-binding domain residue S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 variant susceptible the S protein therapeutic variant Viral viral entry Viral proteins virus transmissibility VoC VOCs X-ray crystallography [DOI] 10.1038/s41467-021-26401-w PMC 바로가기 [Article Type] Article
Associations between Allelic Variants of the Human IgH 3′ Regulatory Region 1 and the Immune Response to BNT162b2 mRNA VaccineArticle Published on 2021-10-192022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome analyses antibody production Antigen-specific B cells approach B cell response BNT162b2 BNT162b2 mRNA cells coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient effective response effective vaccine Escalation flow cytometry Genetic genetic background HS1.2 Human human immunoglobulin IgH locus Immune profile individuals injection levels of antibodies locus NK cell Pfizer–BioNTech progression Protein Region regulatory region required response Safe SARS-CoV-2 SARS-CoV-2 spike serological significant increase single-nucleotide SNP subject subjects subset Support the disease vaccination Vaccine variant [DOI] 10.3390/vaccines9101207 PMC 바로가기 [Article Type] Article
Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactionsArticle Published on 2021-10-192022-10-29 Journal: Nature Communications [Category] COVID-19, [키워드] aggregate aggregates association Cell cells cellular Contact contribute determinant disease dissemination ENhance exchange extracellular space extracellular vesicle glycoprotein Interaction interactions intercellular Mechanisms of disease neurodegeneration neurodegenerative pathogenic pathway Protein Protein misfolding Proteins raise released SARS-CoV-2 spike secreted transfer Transmission vesicular stomatitis virus viral glycoprotein viral infection viral ligand [DOI] 10.1038/s41467-021-25855-2 PMC 바로가기 [Article Type] Article
In Vitro Effect of Taraxacum officinale Leaf Aqueous Extract on the Interaction between ACE2 Cell Surface Receptor and SARS-CoV-2 Spike Protein D614 and Four MutantsArticle Published on 2021-10-172022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] ACE2 ACE2 binding inhibitor ACE2 receptor applicability aqueous B.1.617.2 Compound COVID-19 D614G dandelion Delta E484K Effect Efficacy Extract form human ACE2 receptor Immune escape in vitro result K417N kidney leaf lentivirus lung cell lung cells multiple mutation mutant N501Y new SARS-CoV-2 Non-invasive Particle prevented pro-inflammatory Prophylaxis Protein–protein interaction pseudotyped reported Research S1 spike mutation Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 prevention SARS-CoV-2 spike secretion sequence shown spike surface Taraxacum officinale the spike protein variant wild type Wuhan [DOI] 10.3390/ph14101055 PMC 바로가기 [Article Type] Article