Immune Response of Adult Sickle Cell Disease Patients after COVID-19 Vaccination: The Experience of a Greek CenterBrief Report Published on 2022-02-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Activation acute respiratory syndrome association benefit Cell center complement coronavirus Coronavirus disease-19 COVID-19 COVID-19 pandemic Critical determine disease dose experience greater Hemoglobinopathies immune response Immunocompromised patients Infection mRNA vaccine neutralizing antibody pandemic Patient PROTECT response SARS-CoV-2 SCD second dose Sickle Sickle cell disease Spread susceptibility [DOI] 10.3390/jcm11040937 PMC 바로가기 [Article Type] Brief Report
The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamstersB.1.427/1.429(엡실론) SARS-CoV-2 변종은 시리아 햄스터의 조상 B.1(614G)보다 더 치명적입니다.Research Article Published on 2022-02-102022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] addition airway airways Alpha animal models Antibody neutralization B.1 B.1.1.7 B.1.351 B.1.427 B.1.429 Beta body weight Body weight loss Brazil Clinical data convalescent patient Convalescent patients Critical determine dissemination Efficiency Epsilon evade experiments explain hamster hamsters help highest Human human population in vitro India Infection infections late stage lineages lung Lungs maintain moderate nasal Nasal cavity New observé oral swab oral swabs Oropharyngeal oropharynx P.1 P.2 parenchyma plasma pre-existing immunity recipients replicate Replication SARS-CoV-2 variant SARS-CoV-2 variants severe disease severe lung pathology sgRNA shown significant difference significant differences South Africa Spread susceptibility Transmissibility Transmission Vaccine Vaccine-induced immunity variant variants variants of SARS-CoV-2 Viral Viral RNA virulence virulent weight loss Zeta [DOI] 10.1371/journal.ppat.1009914 PMC 바로가기 [Article Type] Research Article
Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine천연 SARS-CoV-2 감염 또는 COVID-19 백신에 의해 소아에서 유도된 중화 항체에 대한 오미크론 변이체 감수성Coronaviruses Published on 2022-02-102022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] adult COVID-19 patient adult COVID-19 patients Affect age Antibody Response Antibody titer Beta Beta variant BNT162b2 breakthrough infections children collected conducted COVID-19 patient COVID-19 patients COVID-19 vaccine Critical demonstrated individual Live virus microneutralization MOST Mutation neutralization neutralizing antibody Neutralizing antibody response Neutralizing antibody titer of BNT162b2 omicron Omicron variant pediatric Pfizer-BioNTech Re-infection recipient recipients recovered COVID-19 patient Recovered COVID-19 patients Reinfection risk SARS-CoV-2 SARS-COV-2 infection serum Serum Neutralization specimen specimens Spike protein susceptibility susceptible the spike protein threshold titre Vaccine vaccine breakthrough infection vaccine breakthrough infections variant variant of concern variants virus [DOI] 10.1080/22221751.2022.2035195 PMC 바로가기 [Article Type] Coronaviruses
Misinformation, believability, and vaccine acceptance over 40 countries: Takeaways from the initial phase of the COVID-19 infodemicResearch Article Published on 2022-02-092022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] association country Course COVID-19 COVID-19 pandemic Critical defend GDP implication individual infodemic information initial misinformation pandemic platform Prevalence Public health intervention Region Research response risk social distancing Spread susceptibility susceptible vaccination Vaccine wearing masks [DOI] 10.1371/journal.pone.0263381 PMC 바로가기 [Article Type] Research Article
Effectiveness of Antiviral Therapy in Highly-Transmissible Variants of SARS-CoV-2: A Modeling and Simulation StudyPharmacology Published on 2022-02-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Alter antiviral drug antiviral therapy Antiviral treatment changes in characterized clinical trial correlated COVID–19 different time point Effectiveness Efficacy EIDD-2801 experimental drug greater transmissibility Hydroxychloroquine include Infection inhibiting viral replication initial initiated less mathematical disease modeling modeling molnupiravir Mutagenesis Paxlovid Pharmacometrics post inoculation post-hoc analysis Prophylactic Reproduction number SARS-COV-2 infection SARS-CoV-2 variants SARS–CoV-2 variants Simulation susceptibility susceptible Total Transmissibility transmissible variant Treatment Vaccine variant variants of concern variants of concern (VOCs) viral kinetic modelling Viral load viral mutation VoC VOCs was reduced while wild type [DOI] 10.3389/fphar.2022.816429 PMC 바로가기 [Article Type] Pharmacology
Age-Related Susceptibility of Ferrets to SARS-CoV-2 InfectionSARS-CoV-2 감염에 대한 흰 족제비의 연령 관련 감수성Article Published on 2022-02-092022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected age animal Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated described differential expression dose expressed expressing Factors ferret ferrets ferrets. health condition higher infectivity humans individual individuals infectious dose Infectious virus inoculated intranasally nasal observation observations Older outcome platform replicate Replication respiratory SARS-CoV-2 SARS-COV-2 infection secretion Seroconversion severe acute respiratory syndrome Coronavirus shedding susceptibility tissues TMPRSS2 Transcription upper respiratory tract Viral viral entry viral replication virus virus entry [DOI] 10.1128/JVI.01455-21 PMC 바로가기 [Article Type] Article
Role of genetic variants and host polymorphisms on COVID‐19: From viral entrance mechanisms to immunological reactionsReview Published on 2022-02-082022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE ACE2 acute respiratory syndrome Affect age antiviral immunity Care caused CD26 cells Characteristics contribute coronavirus Coronavirus disease 2019 COVID‐19 COVID‐19 Critical DBP Diabetes Mellitus disease Ethnic groups Factor Gender Genetic genetic diversity genetic factor Genetic polymorphism Genetic variant genetics geographical locations higher risk highly pathogenic Host host immunity human leukocyte antigen hypertension IFITM3 IL‐6 immunological reaction implication individual Inflammatory response involved knowledge mechanism men Mortality obesity Pathogenesis pathogenic mechanism pathogenicity pathologic processe pathologic processes polymorphism Population populations risk of death role SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 serological response several gene severity susceptibility the disease TMPRSS2 variant Variation virus [DOI] 10.1002/jmv.27615 PMC 바로가기 [Article Type] Review
Analyzing the Effect of Vaccination Over COVID Cases and Deaths in Asian Countries Using Machine Learning ModelsCellular and Infection Microbiology Published on 2022-02-082022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] analyzed Asian Complete Contact COVID COVID-19 COVID-19 case COVID-19 infection database dataset death determine dose doses droplets Effect Efficacy Factor fluctuation help Infection investigated Karl Linear regression Linear regression analysis machine learning Model mortality rate mutated nasal OLS regression over Patient pharyngeal polynomial distribution positive predict Regression model second Spread Support vector machine (SVM) susceptibility SVM vaccinated individual vaccination vaccine dose virus was performed was used [DOI] 10.3389/fcimb.2021.806265 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchySARS-CoV-2 변이체는 면역 우세 계층이 이동된 항체 반응을 유발합니다Research Article Published on 2022-02-082022-09-10 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] (Beta 501Y.V2 affected antibodies antibody Antibody Response B.1.351 B.1.351 variant Beta conserved delta variant determine Donor donors elicit elicited epitope Epitopes Frequency Human humans Immunity immunodominance immunodominant infected with SARS-CoV-2 Infection Influenza isolate isolates less mutant mutated Mutation neutralization Neutralizing activity polyclonal antibodies polyclonal antibody produced RBD Region residue SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera serum Specificities specificity spike epitopes spike receptor-binding domain susceptibility the antibody response the RBD vaccination variant variants Viral viral isolates viral spike virus viruses while [DOI] 10.1371/journal.ppat.1010248 PMC 바로가기 [Article Type] Research Article
Humoral and Cellular Responses to COVID-19 Vaccination Indicate the Need for Post-Vaccination Testing in Frail PopulationArticle Published on 2022-02-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis analyzed anti-SARS-CoV-2 anti-spike antibody antibodies antibody Antibody titer BNT162b2 vaccine cellular immunity Cellular responses controls correlation COVID-19 determine dose Efficacy Evidence flow cytometry General population humoral immune marker indicated individual individuals Infection interferon gamma measure median age neutralization titer non-responder nursing home parameter Population proportion response SARS-CoV-2 secretion sera serum serum neutralization titer significant decrease spike IgG susceptibility Testing vaccination virus [DOI] 10.3390/vaccines10020260 PMC 바로가기 [Article Type] Article