Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative reviewReview Published on 2022-04-022022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] β‐d‐N4‐hydroxycytidine acute respiratory syndrome administration antiviral agent cause clinical clinical trials coronavirus coronavirus disease COVID‐19 COVID‐19 DNA Efficacy EIDD‐2801 error catastrophe expected host cell in vivo experiment inhibit molnupiravir Mutagenesis mutagenic mutated pandemic Patient Placebo RdRP recent finding Replication reported RNA‐dependent RNA polymerase SARS‐CoV‐2 therapeutic efficacy therapeutic strategy therapy Trial turn variant Viral RNA virus [DOI] 10.1002/jmv.27730 PMC 바로가기 [Article Type] Review
Propagation network of tailings dam failure risk and the identification of key hazards Research Published on 2022-04-022022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] Analysis cause change Characteristics complex DAM determine hazard hazards identify information problems Propagation resulting risk [DOI] 10.1038/s41598-022-08282-1 [Article Type] Research
The anti-C5a antibody vilobelimab efficiently inhibits C5a in patients with severe COVID-19항-C5a 항체 빌로벨리맙은 중증 COVID-19 환자에서 C5a를 효율적으로 억제합니다Article Published on 2022-04-012022-09-11 Journal: Clinical and translational science [Category] 임상, 진단, [키워드] 1:1 Activation adaptive Analysis anaphylatoxin C5a antibody assigned benefit best Blood C3a C5a cause Chain Reaction Coagulation Coagulation system Concentration control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia demonstrated drug concentration enzyme favor geometric geometric mean IFX-1 Infection infection site inhibit IQR leads median monoclonal antibody monocyte Monocytes neutrophil Neutrophils oxidative Patient plasma polymerase chain polymerase chain reaction Randomly ranged real-time polymerase chain reaction receive releases reported Result Safe Sample secondary outcome severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia supportive care suppressed suppression tissue damage Trial vilobelimab [DOI] 10.1111/cts.13213 PMC 바로가기 [Article Type] Article
Novel antiviral effects of chloroquine, hydroxychloroquine, and green tea catechins against SARS CoV-2 main protease (Mpro) and 3C-like protease for COVID-19 treatmentReview article Published on 2022-04-012022-10-05 Journal: Clinical Nutrition Open Science [Category] 변종, 치료법, 치료제, [키워드] 3CL activities Analysis Anti-viral antiviral activity Antiviral effect cause Chloroquine collected Compound convalescent Convalescent plasma therapy coronavirus Covaxin COVID 19 COVID-19 COVID-19 patient CoVs death Direct docking drug ECG EGCG enzyme Epigallocatechin-3-gallate examined Google Scholar green tea HCQ Health Health care system Human Hydroxychloroquine include inhibitor MPro novel objective occur pandemic pathogen positive positive-sense single-stranded RNA protease representing Result SARS CoV-2 Science suggested Treatment Viral diseases virus [DOI] 10.1016/j.nutos.2021.12.004 [Article Type] Review article
Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID orchitis in BrothersConference abstract Published on 2022-04-012022-10-05 Journal: The journal of sexual medicine [Category] 변종, [키워드] ACE2 ACE2 pathway Affect affected age amino acid change antigens average Blood body aches Brother cause cellular cellular entry chromosome 7 circulating controls cough COVID COVID-19 COVID-19 patient Critical current Cytokine storm DNA extraction Evidence examined Exome Extracellular Fever FIVE frameshift Frequency Genetic genetic susceptibility Genotype Human hypothese IgG Inflammation involved kidneys less liver Lungs men Mutation NACAD nonsynonymous objective organ Pain pathogenicity Patient patients PCR PCR positive performed plasma samples polymerase chain population prevalence Prevalence PROTECT R&D Systems report Result SARS CoV-2 SARS-CoV2 Sequencing Serum level soluble ACE2 sore throat subject susceptibility Symptom syndrome testicular pain Transport USA variant variants Vascular endothelium WES while with COVID-19 [DOI] 10.1016/j.jsxm.2022.01.068 [Article Type] Conference abstract
Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progressionResearch article Published on 2022-04-012022-10-05 Journal: Heliyon [Category] 바이오마커, 진단, [키워드] Analysis average Biomarkers carried cause CD10 COVID-19 CRP demonstrated diagnostic Disease progression disease severity eight elevated expression feature hospital identify identifying IL-6 immature Immune phenotype immunological immunological characteristics Inflammation Laboratory lymphoid machine learning management marker monocyte myeloid cell Neutrophil maturity Neutrophils Patient positive SARS-CoV-2 PCR pro-inflammatory cytokine progression recruited risk factor routine SARS-COV-2 infection severe COVID-19 severe disease soluble CD25 were measured [DOI] 10.1016/j.heliyon.2022.e09230 [Article Type] Research article
Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection바이러스성 호흡기 감염에서 박테리아를 구별하기 위한 신속한 숙주 유전자 발현 검사의 전향적 검증Multicenter Study Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] 유전자 메커니즘, 진단, [키워드] 95% CI absence acute COVID-19 acute respiratory illness age Analysis antibacterial therapy antibiotic ARI Asian Bacterial Bacterial infection black Care cause Characteristics children clinical clinically Cohort Concordance diagnostic Emergency Departments enrolled Enrollment entire cohort Ethnicity expression febrile female followed by group groups Hispanic Host host gene host gene expression host response IMPROVE individual IQR less likelihood male median age Messenger RNA multicenter Native Negative predictive value NPV offer outcome outcomes participant Participants pathogen Patient patients with ARI patients with COVID-19 performance Positive predictive value Predictive value primary analysis Probability procalcitonin Prospective quantified Rapid reported respiratory Respiratory illness resulting sensitivity specificity stratified Test the median validation Viral viral infection white with COVID-19 [DOI] 10.1001/jamanetworkopen.2022.7299 PMC 바로가기 [Article Type] Multicenter Study
First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity ReactionPfizer-BioNTech mRNA COVID-19 백신(BNT162b2, Comirnaty)의 초기 투여 후 치명적인 전격성 괴사성 호산구성 심근염의 첫 번째 확인된 사례: 극히 드문 특발성 과민 반응Case Reports Published on 2022-04-012022-09-12 Journal: Journal of Clinical Immunology [Category] 진단, [키워드] adverse event adverse events Autopsy benefit BNT162b2 cause Complete Complication COVID-19 COVID-19 infection COVID-19 vaccines death described drug early diagnosis eosinophil Eosinophilic eosinophilic myocarditis facilitate first dose fulminant Hospital admission hypersensitivity hypersensitivity reaction Identified Intervention less male Mild mortality risk mRNA mRNA COVID-19 vaccines mRNA-based myocarditis Myopericarditis non-specific clinical feature observation occurred Other Pfizer-BioNTech reaction risk second dose Transient Treatment triggered vaccination Vaccine variety [DOI] 10.1007/s10875-021-01187-0 PMC 바로가기 [Article Type] Case Reports
Consider Hemophagocytic Lymphohistiocytosis as a New Cause of Death in COVID-19 With Presentation of Acute Liver Failure: A Case Report급성 간부전을 나타내는 COVID-19의 새로운 사망 원인으로 혈구탐식성 림프조직구증을 고려하십시오: 증례 보고Case Reports Published on 2022-04-012022-09-11 Journal: The Pediatric Infectious Disease Journal [Category] 바이오마커, [키워드] cause COVID-19 hemophagocytic lymphohistiocytosis New presentation report [DOI] 10.1097/INF.0000000000003487 PMC 바로가기 [Article Type] Case Reports
Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)코로나바이러스 질병 2019(COVID-19)의 NETosis에서 레닌-안지오텐신 시스템의 역할Review Published on 2022-04-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACEi angiotensin Angiotensin II angiotensin II type 1 receptor blockers Angiotensin system angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors antagonist ARBs blocker Blood blood pressure Brain cause Complication contribute coronavirus disease COVID-19 death endocytosis Evidence explain Extracellular help hypertension induce Infarction involved kidney Low-density granulocytes lung mechanism Myocardial infarction NET NETosis NETs neutrophil neutrophil activation Neutrophil extracellular trap Neutrophil extracellular traps neutrophil recruitment Numerous organ Patient patients with COVID-19 procoagulant promote recent recent findings receptor reduce regulate Renin renin-angiotensin system risk role severe COVID-19 stroke thrombosis Treatment Trigger virus [DOI] 10.1016/j.biopha.2022.112718 PMC 바로가기 [Article Type] Review