Altered phenotype and functionality of varicella zoster virus-specific cellular immunity in individuals with active infectionArticle Published on 2015-02-152023-05-31 Journal: The Journal of Infectious Diseases [Category] 두창, 수두, [키워드] cellular immunity herpes zoster shingles T cells Varicella zoster virus. VZV [DOI] 10.1093/infdis/jiu500 PMC 바로가기
Tailoring Subunit Vaccine Immunity with Adjuvant Combinations and Delivery Routes Using the Middle East Respiratory Coronavirus (MERS-CoV) Receptor-Binding Domain as an AntigenResearch Article Published on 2014-11-182022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] adjuvant antibody Antigen BALB/c mice Cell-mediated immunity cellular immune responses cellular immunity Combination CpG Critical cytokine production delivery effective elicited ELISpot assay evaluated Freund’s adjuvant humoral Humoral immunity hydroxide hypothesised IFA IFN-γ IgG immune response Immunity immunized immunogenic IMPROVE indicated intramuscularly investigated MERS-CoV MERS-CoV RBD mice Middle East Modification murine Neutralizing antibodies neutralizing antibody offered pandemic Protein purified RBD regimen respiratory respiratory syndrome coronavirus robust route rRBD spot-forming cell subunit T-cell Response the receptor-binding domain vaccination Vaccine was tested [DOI] 10.1371/journal.pone.0112602 PMC 바로가기 [Article Type] Research Article
Identification and genotyping of feline infectious peritonitis-associated single nucleotide polymorphisms in the feline interferon-γ geneResearch Published on 2014-05-212022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] allele amplification analyzed Asymptomatic caused cellular immunity coronavirus correlation Critical decrease effective Factor Feline infectious peritonitis Genotype genotyping heterozygous genotype identification IFN-γ Immune-mediated Infection interferon-γ intron 1 investigated isolates lethal disease morbidity Mutation outcome PCR plasma polymorphism Protective resistant allele Sequencing shown significant decrease Single nucleotide polymorphism SNP the disease thought Treatment Vaccine virulent [DOI] 10.1186/1297-9716-45-57 PMC 바로가기 [Article Type] Research
Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic북미 전염병 동안 숙주 인구에 대한 HIV-1 적응의 유전형 및 기능적 영향Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate adaptation analyzed Antiviral antiviral immunity assessment average Boston cellular immunity changes in characterized circulating codon Cohort Consensus consequence detectable enrolled Epidemic ERAS escape mutation Evolution exhibiting explain Frequency functional Gag greater HIV HIV-1 HLA Host immune immune escape mutation immune escape mutations Impact implication in vitro Increases individual information median medians Mutation New York North North America Patient persistence phenotypic Phylogeny polymorphism Polymorphisms Population Protective Protein reconstructed reduce remained replication capacity residue Result San Francisco selected sequence specimen Spread subsequent suggested Support the epidemic the median Transmission unlikely Viral viral fitness Viral proteins virus [DOI] 10.1371/journal.pgen.1004295 PMC 바로가기 [Article Type] Research Article
Pathogenic Responses among Young Adults during the 1918 Influenza PandemicArticle Published on 2012-02-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] 1918 Influenza Pandemic bacterial pneumonia CD8+ lymphocytes cellular immunity Epidemiology Influenza influenza virus core proteins Mortality nucleoprotein Pandemics viruses World War I [DOI] 10.3201/eid1802.102042 PMC 바로가기