Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea VirusImmunology Published on 2022-01-192022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] amino acid sequence B-cell epitope cause Complete consensus sequence contribute demonstrated disease ELISA testing epidemic diarrhea epitope Epitope prediction genetic diversity greater group high mortality rate identify immune stimulation immunodominant epitope immunoinformatics insight linear linear B-cell epitope M protein membrane membrane protein NCBI database neutralization Neutralizing neutralizing epitope nine offer PEDV peptide peptide-based immunoassays Porcine epidemic diarrhea virus predicted profile Protein Proteins provided retrieved S2 subunit sera Seven Spike protein strain Strains the S protein the Spike Vaccine virus Virus neutralization [DOI] 10.3389/fimmu.2021.785293 PMC 바로가기 [Article Type] Immunology
mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variantmRNA 부스터 면역화는 SARS-CoV-2 오미크론 변이체에 대한 강력한 중화 혈청 활성을 유도합니다Brief Communication Published on 2022-01-192022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 변종, 진단, [키워드] antibodies BNT162b2 booster Booster vaccine both groups Clinical use Cohort convalescent individual convalescent individuals COVID-19 vaccine dose elicit epitope Epitopes globe glycoprotein humoral immune response immune evasion immunization IMPROVE in both group individual Infection lack monoclonal antibodies monoclonal antibody mRNA Mutation neutralization Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody neutralizing capacity omicron Omicron variant polyclonal sera Pseudovirus neutralization assays rapid increase recipient recipients SARS-CoV-2 sera serum serum neutralizing capacity significant increase spike glycoprotein the SARS-CoV-2 Vaccines variant variant of SARS-CoV-2 Viral viral spike [DOI] 10.1038/s41591-021-01676-0 PMC 바로가기 [Article Type] Brief Communication
CD8 + T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2Immunology Published on 2022-01-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] activate activated T cell Analysis analyzed antigen epitope antigen presentation deficiency antigen-presenting cell binding binding affinity CD8 CD8+ T-cell epitope characterized contribute convalescent COVID-19 patients COVID-19 patients cytolytic deficiency defined dominant epitope epitope epitope peptide examined generate HLA-A*02:01 host immune responses Immune escape immune response in vitro induce pandemic peptide Potential predicted proportion reduced SARS-CoV-2 SARS-CoV-2 virus strain screened significantly spike Spike protein T cell T cells T-cell T-cell activation T-cell epitope T2 cell target cells tetramer the spike protein variant variants Variation variations [DOI] 10.3389/fimmu.2021.764949 PMC 바로가기 [Article Type] Immunology
Comparative analysis of machine learning-based approaches for identifying therapeutic peptides targeting SARS-CoV-2SARS-CoV-2를 표적으로 하는 치료 펩타이드 식별을 위한 기계 학습 기반 접근 방식의 비교 분석Comparative Study Published on 2022-01-172022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Algorithm Algorithms anticipated Antiviral antiviral peptides approach approaches AVP bioinformatics Comparative analysis computational tool conducted coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical datasets develop disadvantage Disadvantages epitope Epitopes evaluate evaluated evaluation metrics Guidance IL-6 IL-6 inducing peptides impacted in silico independent machine learning peptide peptide-based peptides performance assessment. predictor public health robustness SARS-CoV-2 scalability Scientific community Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus therapeutic [DOI] 10.1093/bib/bbab412 PMC 바로가기 [Article Type] Comparative Study
ELISA-Based Analysis Reveals an Anti-SARS-CoV-2 Protein Immune Response Profile Associated with Disease SeverityArticle Published on 2022-01-142022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] antibody approach B-cell epitopes Characteristics clinically cohort of patient COVID-19 COVID-19 infection COVID-19 pandemic disease disease severity ELISA epitope humoral identify immune response immunological IMPROVE Infection investigated knowledge linear epitopes Mild moderate disease outcome Patient peptide plasma sample profile Quantitative response SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 linear epitopes SARS-CoV-2 protein severe disease severity strong immune response Viral protein [DOI] 10.3390/jcm11020405 PMC 바로가기 [Article Type] Article
A multiplex serological assay for the characterization of IgG immune response to SARS-CoV-2SARS-COV-2에 대한 IgG 면역 반응의 특성화를위한 다중 혈청 학적 분석Research Article Published on 2022-01-132022-09-10 Journal: PLoS ONE [Category] 진단, 치료기술, [키워드] anti-S2 Anti-spike antibody Antibody titers Antigen antigenic collected Combination correlation develop Diagnosis diagnostic disease severity domain eight epitope FIVE hospitalized patient hospitalized patients IgG IgG immune response IgG response IgG responses IgGs immune response immunoassay IMPROVE Infection Mild Most patients multiplex N-terminal domain neutralize Neutralizing antibody titer neutralizing antibody titers NTD nucleoprotein Patient presenting RBD Receptor binding domain response responses SARS-CoV-2 SARS-COV-2 infection sera Serological assay serological assays spike subunits tested the disease the Spike vaccination Viral viral infection virus [DOI] 10.1371/journal.pone.0262311 PMC 바로가기 [Article Type] Research Article
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variantsSARS-CoV-2 베타에 대한 항체 반응은 다른 변이체와의 항원 거리를 강조합니다Article Published on 2022-01-122022-09-10 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Abstract Alter Analysis antibody Antibody Response antigenic antigenic structure Beta Beta variant binding conserved COVID-19 Delta E484K epitope escape Express immune responses include individual infected with SARS-CoV-2 K417N mAb mAbs multiple mutation multiple mutations mutated Mutation N-terminal domain N501Y neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody NTD other variant pandemic Patient performed RBD Receptor-binding domain Recognition recognize residue residues SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 strain separated sequence serum Spike protein Structure structure-function the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine Vaccine-induced immunity variant variants of SARS-CoV-2 viruses [DOI] 10.1016/j.chom.2021.11.013 PMC 바로가기 [Article Type] Article
Epistatic models predict mutable sites in SARS-CoV-2 proteins and epitopesEpistatic 모델은 SARS-CoV-2 단백질 및 에피토프에서 돌연변이 부위를 예측합니다530 Published on 2022-01-122022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid anticipation appearance approach assist build capture characteristic complex concerning coronavirus COVID data-driven models database databases direct coupling analysis domain Efficacy Efficiency epistasis epitope exploration identify immune response immunological increasingly measure MOST mutability mutable mutagenesis data Mutation mutations observations observé other coronaviruses outbreak pandemic pathogenicity predict predicted prediction predictor profile protein stability receiver operating characteristic Receptor binding domain reduce respiratory resulting SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 variants sequence severe acute respiratory syndrome Coronavirus Significance Spike protein Spread statistical model tested the spike protein therapeutic interventions Transmissibility Vaccine Variability variant variants variants of concern Viral Viral diseases viral evolution viral outbreak virus [DOI] 10.1073/pnas.2113118119 PMC 바로가기 [Article Type] 530
Selection and T-cell antigenicity of synthetic long peptides derived from SARS-CoV-2Animal Published on 2022-01-112022-10-30 Journal: The Journal of General Virology [Category] COVID-19, [키워드] activate Activation Alpha Antigen antigenicity approach autologous beta coronavirus caused CD4+ CD8+ T cell Cluster conserved coronavirus demonstrated dendritic cell effective vaccine epitope HLA class I immunogenic in vitro individual induce leucocyte mononuclear cell other coronavirus outbreak pandemic PBMC peptide Peripheral blood Protein proteome Region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2 peptides Selection T-cell T-cell Response T-cells the SARS-CoV-2 the Spike Vaccine variants of SARS-CoV-2 virus [DOI] 10.1099/jgv.0.001698 PMC 바로가기 [Article Type] Animal
Two Opposing Roles of SARS-CoV-2 RBD-Reactive Antibodies in Pre-Pandemic Plasma Samples From Elderly People in ACE2-Mediated Pseudovirus InfectionImmunology Published on 2022-01-112022-10-31 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis antibody blood plasma caused coronavirus correlated cross-reactive antibodies cross-reactive antibody domain elderly epitope function functions group had no IgG antibody Korean mechanism neutralization neutralized Neutralizing Neutralizing activity neutralizing effect Novel coronavirus outbreak plasma plasma sample plasma samples positive pre-pandemic samples pseudotype receptor binding domain (RBD) role Sample SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 S1 shown significantly the SARS-CoV-2 viral infection Viral pneumonia virus was used [DOI] 10.3389/fimmu.2021.813240 PMC 바로가기 [Article Type] Immunology