Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin-converting enzyme 2 in patients with cardiovascular diseaseObservational Study Published on 2020-12-012022-10-05 Journal: European journal of heart failure [Category] SARS, 임상, [키워드] ACE ACE inhibitor ACE2 ACE2 expression ACE2 mRNA ACEi/ARB Analysis angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor ARB assist association biopsy blocker cardiovascular disease cardiovascular diseases cell entry Comorbidities Coronary artery disease Coronavirus disease 2019 correlated COVID-19 COVID-19 pandemic Deleterious demonstrated enzyme expression Factor grafting heart heart failure increase in independent left Left ventricular assist device morbidity and mortality mRNA expression Myocardial pandemic Patient patients treated patients with COVID-19 polymerase chain Protective Quantitative receptor reduced Regulation SARS-CoV-2 significantly significantly increased therapy treated Treatment Trial ventricular White blood cell widespread [DOI] 10.1002/ejhf.2020 PMC 바로가기 [Article Type] Observational Study
Knowledge of COVID-19 among Health Care Workers at a Tertiary Care Hospital of Nepal: A Descriptive Cross-sectional StudyOriginal Article Published on 2020-11-302022-10-30 Journal: JNMA: Journal of the Nepal Medical Association [Category] COVID-19, SARS, [키워드] Corona-virus disease aerosol-generating procedures Analysis Care conducted coronavirus disease COVID-19 cross-sectional disease ENhance Ethical approval expressed Health care Health care worker health care workers healthcare worker heart help higher risk hospital infected patient Infection institutional review board involved IRB knowledge knowledge score lab Nepal Nurse patients physician positive attitude Science Statistical Package Tertiary the mean Treatment was done worker written Informed Consent [DOI] 10.31729/jnma.5266 PMC 바로가기 [Article Type] Original Article
Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells폐 상피 세포를 과발현하는 SARS-CoV-2 코딩 서열의 세포외 소포로 처리한 후 인간 iPSC 심근세포에서 바이러스 RNA 단편 검출Letter Published on 2020-11-302022-09-10 Journal: Stem Cell Research & Therapy [Category] SARS, 치료기술, [키워드] A549 ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cardiomyocytes cardiovascular risk factors caused coding sequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detectable detection direct viral infection epithelial cells Evidence evidence of EVs expression extracellular vesicle Extracellular vesicles global pandemic heart Human iPSCs lung epithelial cell Lung epithelial cells overexpressed overexpressing Patient pluripotent stem cell-derived cardiomyocytes receptor reported respiratory SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes SARS-COV-2 infection SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus stem cells supplementary material Treatment upregulation Viral viral gene viral genes viral genome viral infection Viral RNA viral RNA fragment [DOI] 10.1186/s13287-020-02033-7 PMC 바로가기 [Article Type] Letter
COVID-19 Induced Myocarditis: A Rare Cause of Heart FailureCardiology Published on 2020-11-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] accompanied ACE-2 acute respiratory syndrome binding blood vessels cause Complication coronavirus coronavirus disease cough COVID 19 covid and myocarditis COVID-19 covid-induced myocarditis enzyme expressed failure Fever heart heart failure heart failure with reduced ejection fraction induced investigated lung Lung injury male membrane-bound myocardial injury myocarditis neurological organ pandemic Patient receptor receptors respiratory symptom SARS-CoV-2 Shortness of breath the patient virus [DOI] 10.7759/cureus.11690 PMC 바로가기 [Article Type] Cardiology
The Genetic Dissection of Ace2 Expression Variation in the Heart of Murine Genetic Reference PopulationCardiovascular Medicine Published on 2020-11-202022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] ACE2 ACE2 receptor amplitude Analysis blood pressure BXD mice cardiac arrhythmias cardiac damage cardiovascular cardiovascular complication cardiovascular damage cell entry co-expressed co-expression correlated correlation COVID-19 COVID-19 patients cytokine diagnostic Diastolic blood pressure Dissection Electrocardiography eQTL eQTL mapping expression functional enrichment gene network gene regulaiton Genetic heart identify induce Inflammation Inflammatory involved Level locus mice morphology myocardial injury myocarditis network analysis outcome pathway Pathways Patient Population PPI Protein–protein interaction Quantitative range of variation RAS reference Regulation SARS-CoV SARS-CoV-2 virus signaling pathways significantly sinoatrial conduction strain Strains systemic inflammation TGFβ therapeutic purpose TNFα traits upstream vascular inflammation were used [DOI] 10.3389/fcvm.2020.582949 PMC 바로가기 [Article Type] Cardiovascular Medicine
Simulation and Improvement of Patients’ Workflow in Heart Clinics during COVID-19 Pandemic Using Timed Coloured Petri NetsArticle Published on 2020-11-192022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] bottlenecks cardiovascular disease COVID-19 COVID-19 epidemic COVID-19 patients discrete-event simulation Health healthcare providers Healthcare system Healthcare systems heart heart clinic hospital improvement initial less MOST nosocomial outbreak Patient reduce reduction in risk Simulation Spread timed coloured Petri net Transmission treated Treatment virus Waiting time [DOI] 10.3390/ijerph17228577 PMC 바로가기 [Article Type] Article
Prognostic Impact of Prior Heart Failure in Patients Hospitalized With COVID-19COVID-19로 입원한 환자의 이전 심부전의 예후 영향Article Published on 2020-11-172022-09-11 Journal: Journal of the American College of Cardiology [Category] Coronavirus, 변종, 유전자 메커니즘, [키워드] 95% confidence interval adjusted adjusted odds ratio adverse outcome adverse outcomes age aldosterone angiotensin Characteristics classification clinical Clinical characteristics conducted coronavirus coronavirus disease coronavirus disease-2019 COVID-19 described Ejection fraction Electronic health records etiology failure functional heart heart failure higher risk history hospital Hospitalized Impact in-hospital mortality increased risk inhibitor intensive care intensive care unit left ventricular ejection fraction LVEF mechanical ventilation Mortality Mount Sinai New York City Odds ratio outcome Patient patients hospitalized Renin renin-angiotensin-aldosterone system renin-angiotensin-aldosterone system inhibitor. Retrospective analysis revision System ventricular ventricular ejection with COVID-19 women [DOI] 10.1016/j.jacc.2020.09.549 PMC 바로가기 [Article Type] Article
COVID-19–Associated Nonocclusive Fibrin Microthrombi in the HeartComparative Study Published on 2020-11-162023-06-18 Journal: Circulation [Category] Fulltext, SARS, [키워드] Autopsy COVID-19 heart pathology SARS-CoV-2 [DOI] 10.1161/CIRCULATIONAHA.120.050754 PMC 바로가기 [Article Type] Comparative Study
The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart FailureReview Published on 2020-11-142022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor Activation acute respiratory syndrome adipocyte adipocytes administration adverse outcome amplification amplify antioxidant Cell complex Concentration coronavirus coronavirus disease COVID COVID-19 Cytokine storm Cytokines Cytokines storm death degrade demonstrated development drug enzyme exacerbate Express expression failure fat form global pandemic group heart heart failure heme oxygenase increase infected with COVID-19 Infection Inflammatory cytokine Inflammatory mediators Laboratory Modification Na/K-ATPase obese obese patients obesity pandemic Patient peptide Proteins reactive oxygen species reactive oxygen specy receptor reduction regulate renal responsible risk RNA role ROS ROS production SARS-CoV-2 selective shown Signaling subjects subunit susceptibility systemic systemic cytokine systemic inflammation tissue virus white with COVID-19 [DOI] 10.3390/antiox9111129 PMC 바로가기 [Article Type] Review
Cardiovascular complications and its impact on outcomes in COVID-19Observational Study Published on 2020-11-012022-10-05 Journal: Indian heart journal [Category] SARS, 바이오마커, 임상, [키워드] Acute cardiac injury Acute coronary syndrome age baseline Biomarker bradycardia cardiac cardiogenic Cardiogenic shock cardiovascular cardiovascular system co-morbidities collected Complication coronary syndrome Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients CV complication CV complications diabete ECG electrocardiogram evaluate heart heart failure Hospitalization independent predictor indication inotropic agent Laboratory Limited Logistic regression analysis lymphopenia majority male morbidity and mortality Mortality multivariate myocarditis outcome patients prevalent QT-interval QTc QTC prolongation Shock single center subjects symptomatic Tachycardia Treatment was done widespread worse prognosis [DOI] 10.1016/j.ihj.2020.10.005 PMC 바로가기 [Article Type] Observational Study