Host genetic susceptibility to viral infections: the role of type I interferon induction Reviews Published on 2020-11-202022-10-05 Journal: Genes and Immunity [Category] 유전자 메커니즘, [키워드] Activation allele antiviral property cascade complications Defense events expression functional genetic susceptibility Human humans IFN IFN pathway IFNs individual induction pathway innate immune response interferon ISGs knock-out mice moderate molecular pathogen produced receptors severe complication shown stimulated Type Type I IFN type I interferon variant viral infection viral infections [DOI] 10.1038/s41435-020-00116-2 [Article Type] Reviews
Immune-Modulating Drug MP1032 with SARS-CoV-2 Antiviral Activity In Vitro: A potential Multi-Target Approach for Prevention and Early Intervention Treatment of COVID-19Article Published on 2020-11-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activity acute respiratory distress acute respiratory syndrome Adverse drug reaction Antiviral effect Bioavailability Cell characterized clinical development co-morbidity coronavirus coronavirus disease COVID-19 COVID-19 drugs Cytokine storm demonstrated drug Drug development Efficacy exhibit highlighting increased risk Inflammation innate immune response joint inflammation mechanism Mild occurred older patient Organ failure oxidative stress pandemic physiological action polymorph Preclinical prevention reactive oxygen specy ROS safety profile SARS-CoV-2 scavenging similarity sodium stability syndrome systemic inflammatory response [DOI] 10.3390/ijms21228803 PMC 바로가기 [Article Type] Article
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamstersArticle Published on 2020-11-172022-10-04 Journal: Nature Communications [Category] SARS, 바이오마커, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] animal model bronchopneumonia Clinical practice consolidation COVID-19 COVID-19 patients deaths develop dissemination driving edema effective emergence hamster hamsters help host response Human identify Infection Inflammatory response innate immune response interferon response lung mice mimicking neutrophil infiltration Pathogenesis Pathogens pathology restrict robust SARS-CoV-2 SARS-COV-2 infection severe lung inflammation severe lung injury severe pneumonia Signaling STAT2 target Treatment viral infection virus [DOI] 10.1038/s41467-020-19684-y PMC 바로가기 [Article Type] Article
Hydroxychloroquine Inhibits the Trained Innate Immune Response to InterferonsArticle Published on 2020-11-102022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Antiviral block Blood Candida cellular changes in Chloroquine conditioned coronavirus coronavirus disease COVID-19 COVID-19 patient dampen decreased expression Genes healthy donor Hydroxychloroquine Immunity Infection inhibit Innate innate immune innate immune cell innate immune memory innate immune response Innate immunity interferon interferon response interferon-stimulated genes interferons investigated leukocyte Ligand ligands lipidome lysine mechanism of action Modification modifications Monocytes mononuclear cell Patient patients PBMC PBMCs peripheral Peripheral blood Prophylactic receptor response SARS-CoV-2 SARS-COV-2 infection the interferon trained immunity [DOI] 10.1016/j.xcrm.2020.100146 PMC 바로가기 [Article Type] Article
Middle East Respiratory Syndrome Coronavirus Gene 5 Modulates Pathogenesis in MiceArticle Published on 2020-11-032023-06-14 Journal: Journal of Virology [Category] MERS, [키워드] animal models coronavirus infectious cDNA innate immune response MERS-CoV Pathogenesis [DOI] 10.1128/JVI.01172-20 PMC 바로가기
Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID‐19NK, CD8 및 Tfh 세포의 역학은 중등도 COVID-19 환자에서 사이토카인 및 항바이러스 항체 생성을 매개합니다Original Article Published on 2020-11-032022-09-12 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단, [키워드] abnormal increase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed antibody antiviral antibody B‐cell benefit caused CD226 CD4 CD8 Cell cell count cellular change Chinese patient contribute control patient control patients convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 cytokine cytokine level cytokine levels Cytokines decrease demonstrated Dynamics effector effector memory electrochemiluminescence immunoassay enrolled expression flow cytometry iCoS immune responses increase in Inflammatory cytokine Inflammatory cytokines inhibitory innate immune response lymphocyte maintenance memory moderate NK NK cell NK cells Patient patients with moderate peripheral lymphocyte Pneumonia Prevent recent respiratory RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2‐specific antibodies SARS‐CoV‐2‐specific antibody severe acute respiratory syndrome Coronavirus Severe case severe cases significantly higher significantly increased subset T cell T cells T‐cell Tfh TIM‐3 [DOI] 10.1111/jcmm.16044 PMC 바로가기 [Article Type] Original Article
Can hyperbaric oxygen safely serve as an anti-inflammatory treatment for COVID-19?고압산소가 COVID-19의 항염증 치료제로 안전하게 사용될 수 있습니까?Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] 비임상, [키워드] activate acute respiratory distress acute respiratory distress syndrome Affect Anecdote anti-inflammatory treatment ARDS attenuation breath Can Case report change chemokines Clinical practice compassionate use consequence COVID-19 CT-scan cytokine Cytokines evaluated HBO Hypothesis hypoxia Inflammatory inflammatory cascade inflammatory condition inflammatory conditions Inflammatory response innate immune response innate immune system lung Mild symptom mild symptoms Organ failure oxygen Patient Pneumonitis Prevent Prospective clinical trial pulmonary CT randomized clinical trial reduce reduce mortality respiratory distress safe and reduce SARS-CoV-2 syndrome Tolerance treat Viral [DOI] 10.1016/j.mehy.2020.110224 PMC 바로가기 [Article Type] Article
PA-X protein of H5N1 avian influenza virus inhibits NF-kappaB activity, a potential mechanism for PA-X counteracting the host innate immune responsesArticle Published on 2020-11-012023-06-22 Journal: Veterinary microbiology [Category] 조류인플루엔자, [키워드] H5N1 avian influenza virus IFN-β innate immune response NF-κB signaling pathway PA-X pathogenicity [DOI] 10.1016/j.vetmic.2020.108838
Tea Bioactive Modulate Innate Immunity: In Perception to COVID-19 Pandemic차 생체 활성 조절 타고난 면역: COVID-19 전염병에 대한 인식Review Published on 2020-10-282022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료제, [키워드] accumulate activate affected animal model animal models anti-inflammatory properties caffeine Camellia sinensis cascade combating condition copper coronavirus coronavirus disease COVID 19 COVID-19 COVID-19 pandemic Cytokines Disease progression Disruption Drawing effective EGCG ENhance epigallocatechin epigallocatechin gallate experiments gallate green Immunity immunomodulatory impairment In-vitro Infectious disease Infectious diseases Innate innate immune response Innate immunity interferons iron manganese medium Micronutrient micronutrients mitigate modulate natural killer cell Natural killer cells Novel coronavirus novel coronavirus disease nutritional immunity oxygen Pathways Perception pro-inflammatory cytokines processed provide reactive oxygen specy Selenium signaling pathway Soil tea tea polyphenols theaflavin theobromine theophylline trials upregulating Vitamin vitamins water Zinc [DOI] 10.3389/fimmu.2020.590716 PMC 바로가기 [Article Type] Review
SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral responseArticle Published on 2020-10-272022-11-01 Journal: Cellular and Molecular Immunology [Category] COVID-19, MERS, SARS, [키워드] aggregation antiviral response cause downstream evade glycoprotein host immunity immune evasion innate immune response Innate immunity Interaction IRF3 M protein MAVS mechanism membrane Membrane glycoprotein M morbidity Mortality pathogen Pathways Protein recruitment SARS-CoV-2 SARS-related coronavirus TBK1 TRAF3 type I interferon [DOI] 10.1038/s41423-020-00571-x PMC 바로가기 [Article Type] Article