Combined drug repurposing and virtual screening strategies with molecular dynamics simulation identified potent inhibitors for SARS-CoV-2 main protease (3CLpro)분자 역학 시뮬레이션과 결합 된 약물 재검사 및 가상 스크리닝 전략 SARS-COV-2 주요 프로테아제 (3CLPRO)에 대한 강력한 억제제를 확인했습니다.Article Published on 2021-08-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 신약개발, [키워드] 3CLpro accelerate anti-HIV drugs approach approved binding binding free energy Care catalytic dyad Combined confirmed case coronavirus Cys145 database death disease dissemination drug Drug screening drug-repurposing Epidemic FDA FIVE free energy Health care Health care system His41 HIV idea in viral infection rate inhibit inhibitor inhibitors intensity maturation molecular dynamics Molecular dynamics simulation pandemic pathway protease public health raised Replication reported Research saquinavir SARS-CoV-2 SARS-CoV-2 main protease screened spread to TCM tested these compound these compounds Traditional Chinese medicine traditional Chinese medicines Vaccine Viral Virtual screening [DOI] 10.1080/07391102.2020.1779128 PMC 바로가기 [Article Type] Article
Do economic effects of the anti-COVID-19 lockdowns in different regions interact through supply chains?Research Article Published on 2021-07-302022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, SARS, [키워드] activity Affect complex components country determine economic loss Effect intensity Interaction Japan lockdown lockdowns Prevent produced reduce Region regions Shock spread of COVID-19 [DOI] 10.1371/journal.pone.0255031 PMC 바로가기 [Article Type] Research Article
An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and SeverityReview Published on 2021-07-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] ACE2 ACE2 expression Activation addition addressed adipose Adipose tissue anti-inflammatory factor caloric restriction concerning Consensus COVID-19 diet diet composition disease Effect enzyme Evidence expression Factor greater Health implication increase in Infection intensity modulation obese obesity occur outcomes overexpression Potential protective role renin–angiotensin system risk of infection SARS-COV-2 infection subject suggested tissue [DOI] 10.3390/ijms22157975 PMC 바로가기 [Article Type] Review
Timing of non-pharmaceutical interventions to mitigate COVID-19 transmission and their effects on mobility: a cross-country analysisCOVID-19 전파를 완화하기 위한 비약물적 개입의 시기와 이동성에 미치는 영향: 국가 간 분석Original Paper Published on 2021-07-252022-09-10 Journal: The European Journal of Health Economics [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] Analysis analyzed Beta beta regression models change Contact country COVID-19 COVID-19 pandemic COVID-19 transmission decrease defined determinant disease transmission early stage early stages Effect examined greater Health I12 I18 implementation intensity Intervention lockdown lockdowns logit measure mitigate Mobility National Non-pharmaceutical interventions NPI NPIs pandemic physical physical distancing physical mobility Population population density Probability propensity score matching reduce reduced significantly social distancing social mobility Socioeconomic factor supplementary material Travel [DOI] 10.1007/s10198-021-01355-4 PMC 바로가기 [Article Type] Original Paper
Clinical characteristics of headache after vaccination against COVID-19 (coronavirus SARS-CoV-2) with the BNT162b2 mRNA vaccine: a multicentre observational cohort studyOriginal Article Published on 2021-07-232022-10-27 Journal: Brain Communications [Category] COVID-19, [키워드] affected analysed average BNT162b2 mRNA Care cause Characteristics clinical Clinical characteristics clinical feature complex coronavirus SARS-CoV-2 COVID-19 COVID-19 vaccination COVID-19 vaccine described fatigue forms Germany headache indicated Infectious disease information intensity International Classification of Headache Disorders medication moderate mRNA vaccine multicentre neurological novel coronavirus SARS-CoV-2 Observational cohort study occur Pain participant Participants Patient phenotype Prevent Primary outcome questionnaire reported resulting Side-effects Sociodemographic Spread suffered Symptom Symptoms Treatment United Arab Emirates university hospital vaccination vaccination against COVID-19 Vaccinations variable virus were recorded [DOI] 10.1093/braincomms/fcab169 PMC 바로가기 [Article Type] Original Article
Decline of influenza and respiratory syncytial virus detection in facility-based surveillance during the COVID-19 pandemic, South Africa, January to October 2020남아프리카 공화국, 2020년 1월에서 10월까지 COVID-19 전염병 동안 시설 기반 감시에서 인플루엔자 및 호흡기 세포융합 바이러스 탐지 감소Surveillance Published on 2021-07-222022-09-10 Journal: Eurosurveillance [Category] SARS, 치료기술, [키워드] children circulation close monitoring COVID-19 COVID-19 pandemic Decline Delayed Epidemics impacted implementation implication increase in increases in Influenza influenza vaccine Influenza virus influenza virus strain influenza-like illness initiated intensity Intervention measure Measures Mild opening pathogen Pathogens Prevent reduced respiratory Respiratory illness respiratory syncytial virus Result RSV SARS-CoV-2 School Schools severe respiratory illness severity South Africa Spread subsequent Surveillance surveillance data Vaccine [DOI] 10.2807/1560-7917.ES.2021.26.29.2001600 PMC 바로가기 [Article Type] Surveillance
Investigating the Links Between Vaccination Against COVID-19 and Public Attitudes Toward Protective Countermeasures: Implications for Public HealthCOVID-19에 대한 예방 접종과 보호 대책에 대한 대중의 태도 사이의 연관성 조사: 공중 보건에 대한 시사점Public Health Published on 2021-07-212022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, [키워드] Against age analyze this Attitude caused China clinical trials collected data complex Compliance Control COVID-19 COVID-19 pandemic COVID-19 vaccination did not reduce driver effective eradication exploration Factor Frequency Gender globe Government hand washing hands Health help intensity Mask Masks measure mutations Novel coronavirus observé participant physical distance physical distancing Precaution produced propensity score matching PROTECT Protective protective countermeasures protective immune response PSM Public public health reduction in Research resurgence risk Risk perception SARS-CoV-2 significantly vaccination vaccination against COVID-19 Vaccine Vaccines variant virus wearing masks with COVID-19 [DOI] 10.3389/fpubh.2021.702699 PMC 바로가기 [Article Type] Public Health
Inactivation of SARS-CoV-2 by Simulated Sunlight on Contaminated SurfacesResearch Article Published on 2021-07-212022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, SARS, [키워드] absence acute respiratory syndrome clinical condition conditions Contaminated coronavirus dependent on elevated emerging disease environmental survival experiments greater hidden inactivated inactivation intensity interfering substances L-type strains Lineage majority moderate not correlated occur patients persistence SARS-CoV-2 sensitivity Spread stability stainless steel strain Sunlight surface survival temperature transmission of SARS-CoV-2 unlikely variant viability virus viruses [DOI] 10.1128/Spectrum.00333-21 PMC 바로가기 [Article Type] Research Article
COVID-19 Publications in Family Medicine Journals in 2020: A PubMed-Based Bibliometric AnalysisArticle Published on 2021-07-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] accounted Analysis article articles bibliometric analyses categories category collected conducted Coronavirus disease 2019 country COVID-19 database determine disciplinary English language family Family medicine Google Scholar intensity journal Medicine novel coronavirus disease physician recorded Research the epidemic [DOI] 10.3390/ijerph18157748 PMC 바로가기 [Article Type] Article
Solar UV-B/A radiation is highly effective in inactivating SARS-CoV-2Article Published on 2021-07-202022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Atmospheric science average characteristic Concentration diffusion earth effective Epidemics Epidemiology intensity less lower mortality Mortality mortality data outbreak Pandemics Radiation recorded Region SARS-CoV-2 single-stranded RNA virus Single-stranded RNA viruses Solar Solar physics TCID the SARS-CoV-2 UV light virion virucidal virus viruses [DOI] 10.1038/s41598-021-94417-9 PMC 바로가기 [Article Type] Article