Multi-Organ Lesions in Suckling Mice Infected with SARS-Associated Mammalian Reovirus Linked with Apoptosis Induced by Viral Proteins μ1 and σ1Research Article Published on 2014-03-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 2003 SARS Apoptosis apoptotic caused Cell Characteristics Complication cultured cell expressed Factors host cell in vivo independent induced Infection inoculated investigated involved Isolation lesion mammalian mechanism mice Microscopy myocarditis nerve damage pandemic Pathogenesis pathogenic pathogenicity Pneumonia primary determinant Protein Reovirus reported SARS-coronavirus Suckling virulence were expressed [DOI] 10.1371/journal.pone.0092678 PMC 바로가기 [Article Type] Research Article
Atlas of coronavirus replicase structureArticle Published on 2013-12-162022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Atla bioinformatics coronavirus Coverage Cryoelectron microscopy functional in viral International Microscopy NMR NMR spectroscopy nonstructural protein Pathogenesis produced Protein protein structure Proteins Replication SARS Coronavirus SARS-CoV Small angle X-ray scattering Structure structures variety X-ray crystallography X-ray scattering [DOI] 10.1016/j.virusres.2013.12.004 PMC 바로가기 [Article Type] Article
Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cellsResearch Published on 2013-06-272022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] Cell Cell culture cell lines cells CMV coronavirus cytomegalovirus cytoplasmic detected Deterioration determine different DNA epithelial cell Genetic HCoV-NL63 herpesvirus HHV-6B Human human kidney immunofluorescence assay induce infectious agents initiated Isolation kidney Laboratory Microscopy NL63 observation PCR proximal renal replicate Replication Result RPTEC RT-PCR Sequencing simian virus SV40 virus [DOI] 10.1186/1743-422X-10-213 PMC 바로가기 [Article Type] Research
Isolation and characterization of a variant porcine epidemic diarrhea virus in ChinaResearch Published on 2012-09-122022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] amino acid sequence analysis Analysis case characterized China Chinese Cluster Complete cultures Cytopathic effect determine diarrhea epidemic diarrhea Gene Genes Genome Guangdong identity immunofluorescence indicated intestine isolate Microscopy morbidity Mortality nucleotide nucleotide sequence ORF3 outbreak pathogenicity PEDV Porcine epidemic diarrhea virus reported required sequenced shown South Strains susceptible cell the spike protein variant Vero Cell virus virus isolate vomiting watery whole genome [DOI] 10.1186/1743-422X-9-195 PMC 바로가기 [Article Type] Research
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic ReticulumResearch Article Published on 2008-09-162022-10-28 Journal: PLoS Biology [Category] Coronavirus, [키워드] acute respiratory syndrome alteration Analysis Antiviral applied arising Author biochemical characterized complex connection coronavirus coronavirus cytoplasm cytosol Defense defined dissect double-stranded RNA driven by early stage electron tomography Endoplasmic reticulum endoplasmic reticulum membrane enzyme ER membrane host cell host cell membrane host cell membranes host cells human pathogen implicated in viral induce Infected infected cell interior invagination mechanism mechanisms membrane membrane-bound membranes Microscopy network question raise replicate Replication replication complex replicative protein reported Reticulum reveal RNA RNA genome RNA synthesis RNA virus RNA viruses SARS-coronavirus SARS-CoV Structure subunits Support thought tomography ultrastructure unique Vesicle vesicles viral replication viral RNA synthesis virus Virus-host interactions Web [DOI] 10.1371/journal.pbio.0060226 PMC 바로가기 [Article Type] Research Article
Virus-Like Particles of SARS-Like Coronavirus Formed by Membrane Proteins from Different Origins Demonstrate Stimulating Activity in Human Dendritic CellsResearch Article Published on 2008-07-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] activated activity Antibody Response baculovirus baculovirus bat CD4+ T cell CD40 CD80 CD83 CD86 co-stimulatory molecule compared CoV cytokine Cytokines DC DCs demonstrated dendritic cell different DNA DNA vaccine evidenced Express expression finding Human IL-10 IL-6 immature incorporation indicated information inoculated insect cell labeling led to M protein membrane membrane protein mice Microscopy origin Particle Pathogenesis Population Protein response S protein SARS Coronavirus SARS CoV SARS-CoV SARS-CoV S SARS-like coronavirus secretion SL-CoV stimulate Stimulating T cell response the S protein TNF-α up-regulated Vaccine development Virus-like particle VLP VLPs western blot [DOI] 10.1371/journal.pone.0002685 PMC 바로가기 [Article Type] Research Article
Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 ActivationResearch Article Published on 2008-06-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation ADP-ribosylation Analysis ARF ARF1 association Author cells cellular cellular pathway characteristic complex connection coronavirus coronavirus Coronavirus replication Critical demonstrated dominant-negative downstream Endoplasmic reticulum Express expression Factors GBF1 GTPase GTPases guanine Host Human induce infected cell Infection inhibited inhibiting interfere involved knockdown MDCK cells membrane MHV Microscopy mouse mouse hepatitis mutant nucleotide observation provide Quantitative reduced Replication replication complex required RNA RNA virus secretory pathway significantly siRNA siRNAs structures target vesicles viruses [DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARSResearch Published on 2005-05-112022-10-28 Journal: Respiratory Research [Category] Coronavirus, [키워드] abnormality acute phase acute respiratory syndrome alveolar cell alveolar macrophage Alveolar macrophages BALF Bronchoalveolar lavage Bronchoalveolar lavage fluid CD4/CD8 CD8 cell count cells clearance compared Computed tomography controls coronavirus correlated Course cytokine Cytokines described desquamation detected determine dysregulation Factor Fever High-resolution High-resolution CT HRCT hyaline membrane formation IL-6 IL-8 independent infiltration Inflammatory investigated lung Lung inflammation MCP-1 Microscopy mononuclear cell non-randomized occur Particle Patient patients persistence persistent Plasma cytokine profiles RANTES Resolution Result Retrospective analysis SARS SARS patient significantly subpopulations T lymphocyte T-cell therapy TNF-α [DOI] 10.1186/1465-9921-6-42 PMC 바로가기 [Article Type] Research
Topographic Changes in SARS Coronavirus–infected Cells at Late Stages of InfectionResearch Published on 2004-11-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Actin active site addition atomic Atomic force microscopy Cell change coronavirus cytoskeletal filament Final infected cell Infection involved maturation Microscopy plasma membrane progeny provided Research SARS coronavirus replication SARS-CoV scanning scanning electron microscopy spike Stage virus virus particle virus particles was used [DOI] 10.3201/eid1011.040195 PMC 바로가기 [Article Type] Research