Coronavirus disease 2019 is threatening stroke care systems: a real-world studyResearch Article Published on 2021-03-312022-10-28 Journal: BMC health services research [Category] COVID-19, SARS, [키워드] Admission Affect affected AIS analyzed Care caused China collected coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 pandemic discharge Effect hospital Hospitalization In-hospital measure Metrics Neurological deficit no difference pandemic Patient patients positively correlated Prognosis real-world real-world data Result severity severity and prognosis Spread stroke stroke care Treatment Workflow [DOI] 10.1186/s12913-021-06297-4 PMC 바로가기 [Article Type] Research Article
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development카텝신 L은 인간과 인간화 마우스에서 SARS-CoV-2 감염에 핵심적인 역할을 하며 신약 개발의 유망한 표적입니다Article Published on 2021-03-272022-08-31 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 신약개발, 치료제, [키워드] amantadine anti-influenza drug cathepsin cathepsin L circulating cleaved COVID-19 CTSL disease course drug Drug screening elevated evidenced expression Human human ACE2 human cell human cells humanized in vitro in vivo Infection Infectious diseases inhibited inhibitor knockdown mice molecular basis overexpression patients with COVID-19 positively correlated prevented pseudovirus infection SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein severity significantly Spike protein the SARS-CoV-2 transgenic mice turn virus entry [DOI] 10.1038/s41392-021-00558-8 PMC 바로가기 [Article Type] Article
Diagnostic Value of IgM and IgG Detection in COVID-19 Diagnosis by the Mobile Laboratory B-LiFE: A Massive Testing Strategy in the Piedmont Region모바일 연구소 B-LiFE에 의한 COVID-19 진단에서 IgM 및 IgG 검출의 진단적 가치: 피에몬테 지역의 대규모 테스트 전략Article Published on 2021-03-242022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute infectious disease age Analysis antibodies asymptomatic individual Asymptomatic individuals Care caused Cohort consequence coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases COVID-19 outbreak detect detection detection rate Diagnosis domain emerging biological threats first responders Health Health care help IgG IgM and IgG individual Infectious disease Italy Laboratory Large-scale testing massive Mobile moderate Novel coronavirus nucleocapsid protein performed Piedmont police positively correlated Prevalence professionals Protein Public Health Preparedness RBD protein Region residence responders S-RBD SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 NP antibody SARS-CoV-2 spike SARS-CoV-2 spike receptor-binding domain Seroconversion seroconverted Serological testing Seroprevalence serum serum antibodies serum antibody Sex Strategy Surveillance Testing the SARS-CoV-2 value volunteers Whole blood [DOI] 10.3390/ijerph18073372 PMC 바로가기 [Article Type] Article
Using demographic data to understand the distribution of H1N1 and COVID-19 pandemics cases among federal entities and municipalities of MexicoBiogeography Published on 2021-03-242022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] affected Analysis association confirmed case contagious Control correlated correlation COVID-19 COVID-19 pandemic database death deaths demographic data demographic factor demographic variable distribution element entity evaluate greater H1N1 H1N1 Influenza Pandemic health emergency indicated Infection infections less Local magnitude Mexico Mexico City National novel coronavirus disease observé Outbreaks P -value pandemic Pandemics population density Population size positively correlated Registered Result Spearman Spread Variation was used were recorded [DOI] 10.7717/peerj.11144 PMC 바로가기 [Article Type] Biogeography
Thymidine Phosphorylase Is Increased in COVID-19 Patients in an Acuity-Dependent MannerMedicine Published on 2021-03-222022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] accompanied Acuity acute respiratory syndrome approved C reactive protein caused Clinical use Cohort Comorbidity coronavirus Coronavirus disease 2019 correlated COVID-19 COVID-19 diagnosis CRP D-dimer Department diabete diabetic patients drug effective Emergency evidenced expression food IFN Increased indicated Inflammation inhibitor lactate dehydrogenase LDH marker Massachusetts General Hospital mechanism organ damage Patient plasma platelet activation positive correlation positively correlated provided recent Respiratory disease respiratory symptoms SARS-CoV-2 selective targeting thrombosis thrombotic Thrombotic events thymidine thymidine phosphorylase tipiracil Treatment TYMP with COVID-19 [DOI] 10.3389/fmed.2021.653773 PMC 바로가기 [Article Type] Medicine
What Are the Reasons for the Different COVID-19 Situations in Different Cities of China? A Study from the Perspective of Population MigrationArticle Published on 2021-03-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] activities affected Analysis analyzed China city correlated COVID-19 COVID-19 cases COVID-19 outbreak demographic characteristics distribution early stage Epidemic epidemic prevention and control Epidemic spreading exceeded Frequency GDP hospital indicated key factor measure Migration Perspective Population Population migration positively correlated reason reveal situation Spread spread of COVID-19 the epidemic understanding virus transmission Wuhan [DOI] 10.3390/ijerph18063255 PMC 바로가기 [Article Type] Article
Hyperglycemia and Correlated High Levels of Inflammation Have a Positive Relationship with the Severity of Coronavirus Disease 2019Observational Study Published on 2021-03-182022-10-04 Journal: Mediators of Inflammation [Category] SARS, 임상, [키워드] 95% CI adjusted age analyzed association biochemical blood glucose BMI body mass index C-reactive protein (CRP Characteristics Chinese Clinical course Committee Coronary heart disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical CRP level diabete diabetes diagnostic disease severity enrolled erythrocyte sedimentation rate ESR global public health Glucose help Hospitalization hyperglycemia hypertension identify independent Inflammation Inflammatory inflammatory status initial leucocyte Level lymphocyte neutrophil neutrophil count NLR objective Patient patients with COVID-19 patients with diabete plasma positively correlated relationship Result retrospective cohort study risk factor severity severity of COVID-19 Sex subset treatment guideline was determined [DOI] 10.1155/2021/8812304 PMC 바로가기 [Article Type] Observational Study
Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19 Research Published on 2021-03-172022-10-05 Journal: Modern pathology : an official journal of the Unit [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] analyzed association Autopsy cardiac CD3+ CD68+ macrophage Cell change changes Clinical features Comorbidities correlation COVID-19 determine duration of symptom dysfunction electrocardiographic Factor fatal COVID-19 glucocorticoid IL-6 blockade Immunosuppression incidence infected cells Infection infection with SARS-CoV-2 Inflammation inflammatory cell infiltration Injury laboratory measurements less lymphocyte Lymphocytes Macrophage median Myocardial myocarditis Myocardium pathological change Patient patients treated patients with COVID-19 positively correlated prevalent reported Retrospective study SARS-CoV-2 SARS-COV-2 infection transcriptomic while [DOI] 10.1038/s41379-021-00790-1 [Article Type] Research
Elevated frequencies of CD14 + HLA-DR lo/neg MDSCs in COVID-19 patientsCOVID-19 환자에서 CD14 + HLA-DR lo/neg MDSC의 빈도 증가Research Paper Published on 2021-03-152022-08-31 Journal: Aging (Albany NY) [Category] MERS, 바이오마커, [키워드] albumin analyzed association B cell CD14 Cell change Clinical characteristics correlated correlation COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression COVID-19 severity determined by disease severity elevated evaluate flow cytometry Follow-up Frequency greater HLA-DR Hospital stay hyper-inflammation ICU patient immune responses immunoparalysis Immunosuppression immunosuppressive laboratory data lymphocyte Lymphocyte count lymphocyte counts MDSC Most patients NK cell nucleic acid Oropharyngeal Patient percentage percentages positively correlated Prognosis SARS-CoV-2 SARS-CoV-2 nucleic acid serum albumin severe patients T cell Viral Viral load [DOI] 10.18632/aging.202571 PMC 바로가기 [Article Type] Research Paper
Atrial Arrhythmias in Patients with Severe COVID-19Research Article Published on 2021-03-122022-10-31 Journal: Cardiology Research and Practice [Category] COVID-19, [키워드] arrhythmia Bacterial cardiac troponin China city CKMB collected Comorbidity comparison confirmed COVID-19 case COVID-19 COVID-19 patient Critical Critical disease death demographic determine disease Diseases had more Infection information Mortality Myoglobin Occurrence Older Patient patients with COVID-19 plasma Pneumonia positively correlated Prospective Study severe COVID-19 severe group significantly Symptoms Tachycardia temporary treated with COVID-19 Wuhan younger patients [DOI] 10.1155/2021/8874450 PMC 바로가기 [Article Type] Research Article