CD8+ T Cells Responding to the Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Delivered by Vaccinia Virus MVA in MiceArticle Published on 2018-12-162022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] antigenic target antigenicity BALB/c mice candidate vaccine CD8+ CD8+ T cell CD8+ T cells cellular immune responses conserved death described elicit epitope evaluate expressing help histocompatibility complex humans identify immune correlate immune response immunized MERS-CoV MERS-CoV infection MERS-CoV N MERS-CoV nucleocapsid protein Middle East murine CD8+ T cell epitope murine model MVA vaccine N protein nucleocapsid peptide protective immunity Protein Research respiratory respiratory syndrome coronavirus Responding severe respiratory disease T cell response thought Vaccine vaccinia vaccinia virus virus was used were used [DOI] 10.3390/v10120718 PMC 바로가기 [Article Type] Article
To B or Not to B: Understanding B Cell Responses in the Development of Malaria InfectionB가 될까, 말까: 말라리아 감염의 발전에서 B 세포 반응 이해하기Review Published on 2018-12-142024-08-11 Journal: Frontiers in immunology [Category] 말라리아, [키워드] antibodies B cell biology effective mechanism malaria protective immunity [DOI] 10.3389/fimmu.2018.02961 PMC 바로가기 [Article Type] Review
Optimal protection against Salmonella infection requires noncirculating memory살모넬라 감염에 대한 최적의 보호는 비순환 기억을 필요로 한다.Article Published on 2018-10-092024-08-22 Journal: Microbial Cell Factories [Category] 살모넬라증, [키워드] CD4 T cell protective immunity Salmonella infection tissue-resident memory Vaccines
Oral immunization with a novel attenuated Salmonella Gallinarum encoding infectious bronchitis virus spike protein induces protective immune responses against fowl typhoid and infectious bronchitis in chickens신형 약화된 살모넬라 갈리나룸을 이용한 경구 면역화가 감염성 기관지염 바이러스 스파이크 단백질을 인코딩하여 닭에서 조류 티푸스와 감염성 기관지염에 대한 보호 면역 반응을 유도한다.Research Article Published on 2018-09-122022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, 살모넬라증, [키워드] Affect Against bronchitis caused Cell-mediated immunity clone cloned control group control groups demonstrated disease elicit elicited exhibited expression vector Fowl group humoral IBV induce Infectious Bronchitis Virus Inflammatory lesion Mortality mutant nucleotide sequence Oral Immunization PBS Plasmid protective immune response protective immunity Protein Salmonella shown significantly Spike protein supplementary material tissue tracheal Vaccine virulent virus wild-type [DOI] 10.1186/s13567-018-0588-9 PMC 바로가기 [Article Type] Research Article
Recombinant Infectious Bronchitis Viruses Expressing Chimeric Spike Glycoproteins Induce Partial Protective Immunity against Homologous Challenge despite Limited Replication In VivoVaccines and Antiviral Agents Published on 2018-09-122022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] avian infectious bronchitis virus BeauR bronchitis cause cellular challenge Characteristics characterized chimeric ciliary Clinical sign Clinical signs conducted conformational contagious coronavirus cross-protection determine expressing glycoprotein Heterologous homologous IBV IMPROVE in vitro in vivo induce Limited Live attenuated vaccines M41 mucosal tissue Partial partial protection PROTECT protective immunity recombinant recombinant vaccine reduction in reductions in replicated Replication Respiratory disease responsible rIBV S1 S1 and S2 S2 subunit serotype serum serum antibody single vaccination spike strain surface protein the S1 subunit tracheal Trial vaccination Vaccine Viral load viral RNA load virulent virus [DOI] 10.1128/JVI.01473-18 PMC 바로가기 [Article Type] Vaccines and Antiviral Agents
Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumoniaResearch Article Published on 2018-06-072022-11-01 Journal: JCI Insight [Category] Coronavirus, SARS, [키워드] absence activate activated activated macrophage Activation acute respiratory syndrome adaptive airway Antigen caused coronavirus CoV Heterologous IFN-I immune Immunity immunology independent infiltration Inflammatory inflammatory monocyte influenza A virus Innate immunity inspired air Local lung Lung infection Lungs monocyte Monocytes morbidity Mortality mucosal mucosal immune murine nasal nasal mucosa NK cell Particle pathogen Pneumonia priming PROTECT protective immunity provide pulmonary lymph nodes reduced SARS-CoV Signaling significantly these cell Type I IFN viral infections Virology virus virus infection virus pneumonia [DOI] 10.1172/jci.insight.99025 PMC 바로가기 [Article Type] Research Article
Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirusArticle Published on 2018-04-042022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] addition anti-S antigen expression clinical trials control group effective ELISpot assay enhanced Final highlight IgG response immune response immunization immunized inactivated Infection interferon-γ Live virus lung membrane MERS-CoV mice Middle East Neutralizing activity nucleocapsid plaque-forming units protective immunity Protein Proteins public health threat reduced respiratory syndrome coronavirus Safe sera spike Spike protein structural proteins T-cell immunity tested the S protein transduced vaccination Vaccine Vaccines virus virus titers [DOI] 10.1038/s41426-018-0056-7 PMC 바로가기 [Article Type] Article
BCG and Adverse Events in the Context of Leprosy한센병 맥락에서의 BCG와 부작용Article Published on 2018-04-042024-08-01 Journal: Frontiers in immunology [Category] 한센병, [키워드] adverse events BCG (re)vaccination biomarker profiles household contacts leprosy Mycobacterium leprae protective immunity [DOI] 10.3389/fimmu.2018.00629 PMC 바로가기
Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI ® induces enhanced serological, cellular and protective immune responsesResearch Article Published on 2018-03-152023-05-31 Journal: Drug Delivery [Category] Fulltext, 조류인플루엔자, [키워드] Adaptive immunity Cationic polymers H5N1 vaccine Influenza mouse model protective immunity [DOI] 10.1080/10717544.2018.1450909 PMC 바로가기 [Article Type] Research Article
Immune efficacy of an adenoviral vector-based swine influenza vaccine against antigenically distinct H1N1 strains in miceArticle Published on 2017-11-012023-06-23 Journal: Antiviral Research [Category] 신종인플루엔자, [키워드] avian-like H1N1 hemagglutinin protective immunity recombinant adenovirus swine influenza virus [DOI] 10.1016/j.antiviral.2017.09.009